ARINA-1 Clinical Trial with nebulized solution-NO ANTIBIOTICS

Posted by becleartoday @becleartoday, Aug 17, 2023

GOOD NEWS!!!

We have been asking for bronchiectasis treatments that are not antibiotics, and we have been heard!

Dr. Charles Daley is a well-respected expert from National Jewish Health in Denver. He was a keynote speaker at the World Bronchiectasis Conference and gave the closing remarks.

Dr. Daley is also the principal investigator of a study evaluating ARINA-1, a nebulized solution manufactured by Renovion that has been shown to prevent mucus from clogging our airways. Clogged airways cause inflammation and infection, a cycle we try to break with daily airway clearance and, often, antibiotics.

ARINA-1 is a sterile formulation that is manufactured under strict guidelines. The solution includes glutathione, ascorbic acid, and a buffer to modify the pH.

The trial will measure ARINA-1’s impact on quality of life, mucus viscosity, and inflammation.

Researchers are looking for 25 more participants for the 28-day study. Participants need to be diagnosed with non-CF bronchiectasis and have mucus. In addition to National Jewish in Denver, trial sites are located in Baltimore; Philadelphia; Seattle; Birmingham, AL; New Orleans; Tyler, TX; Winston-Salem, NC; Portland, OR; and Charleston, SC. If you live in or around one of these areas and are interested in the trial, let me know.

Click on the following link to clinicaltrials.gov for more information on the ARINA-1 trial.

https://tinyurl.com/tsh6fjnr

I am working with Renovion and researchers to share this opportunity, and I can help answer basic questions regarding:

-Participating doctors
-Laboratory studies of ARINA-1
-How nebulizing this solution differs from nebulizing glutathione alone or orally administered NAC
-The importance of the combination of glutathione and ascorbic acid

If you have other questions about the trial, the drug or how to enroll, let me know and I can help you get an answer from the Chief Scientific Officer at Renovion who is a great resource.

Most importantly, discuss this trial with your doctor.

Dr. Daley implored us to get involved in bronchiectasis and NTM research. Let’s show him and the researchers working on our behalf that we are willing to participate whenever possible.

Interested in more discussions like this? Go to the MAC & Bronchiectasis Support Group.

@irenea8

Yes TheraNaturals is the best one and what I use. I believe it is quite sterile. I have some other kind of glutathione for sublingual use but only tried it once. Do you find it helpful?

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The THERAnaturals comes in a capsule which I open it up, place under my tongue and leave it there until it stops foaming. After, I take a sip of water and wash it down. I also nebbed it. When I used it regularly I thought it was helpful but not magic. The gunk needs to come out one way or another to maintain as much health as possible. For now, the routine of NAC/mucinex, albuterol, 7% saline with clearance via AD app is the best I've found to date. It's all very individual.

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@scoop

The THERAnaturals comes in a capsule which I open it up, place under my tongue and leave it there until it stops foaming. After, I take a sip of water and wash it down. I also nebbed it. When I used it regularly I thought it was helpful but not magic. The gunk needs to come out one way or another to maintain as much health as possible. For now, the routine of NAC/mucinex, albuterol, 7% saline with clearance via AD app is the best I've found to date. It's all very individual.

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When you take the NAC/Mucinex do you take at the same time and how long before airway clearance? I sometimes find that taking something does not work till the next day! Do you get any side effects from taking both daily? I am never able to take things every day or they back fire on me so to speak. They will either stop helping or I will get side effects. In my case I also find that unusual things help the mucus to come up more thoroughly such as Zinc (liquid tincture drops). Zinc also seems to pull me out of exacerbations but I cannot take it too often.

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@irenea8

Linda, In my last visit I brought Arina-1 up to my Pulmo. It was clear he had not heard of it. I just messaged him about the study you posted. Dr Douglas Hornick in the specialty pulmonary department at the University of Iowa Hospitals and Clinics. He specializes in Cystic Fibrosis and Bronchiectasis, difficult pulmonary infections etc. I would love for U of IA to be included if they are receptive. Is there any way to facilitate that? also I would very much like to know the difference between nebulizing Arina-1 and glutathione mixed with saline. I try to do that every other day. I would love to get involved but nothing is close to me. I do produce abundant mucus! And have chronic Pseudomonas. Also wondered if any of the Drs discussed the use of CFTR modulators for NCFBE? I have been reading there is some thought of that? It has been such a huge game changer for the CF people. THANK YOU for all you are doing!

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I’d love to see Mayo Clinic participate!

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@irenea8

When you take the NAC/Mucinex do you take at the same time and how long before airway clearance? I sometimes find that taking something does not work till the next day! Do you get any side effects from taking both daily? I am never able to take things every day or they back fire on me so to speak. They will either stop helping or I will get side effects. In my case I also find that unusual things help the mucus to come up more thoroughly such as Zinc (liquid tincture drops). Zinc also seems to pull me out of exacerbations but I cannot take it too often.

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@irenea8 Yes, together same time. So far, no ill effects. I drink 32 oz with the combo. In between drinking the 32 oz I take a puff of albuterol, then a puff of symbicort (asthma). I hold my breathe as long as possible after inhaler use, then rinse my mouth. About 15 later clearance time.

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@scoop

@irenea8 Yes, together same time. So far, no ill effects. I drink 32 oz with the combo. In between drinking the 32 oz I take a puff of albuterol, then a puff of symbicort (asthma). I hold my breathe as long as possible after inhaler use, then rinse my mouth. About 15 later clearance time.

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It is hard to believe that the NAC and Mucinex could get into your system that fast! Maybe some is left over from the previous day. That is alot of water! We sure all have different bodies.

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@irenea8

It is hard to believe that the NAC and Mucinex could get into your system that fast! Maybe some is left over from the previous day. That is alot of water! We sure all have different bodies.

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The NAC is a clear (gelatin?) capsule which dissolves quickly, excess water helps a lot. Mucinex likely takes longer. Between my sinuses and lungs I need all the help I can get. Room temperature water easier to drink than refrigerated. According to Ayurvedic medicine, room temperature water is healthier for the gullet/gut than cold water. We loose fluids at night through respiration.

According to the label, Mucinex dosing one tablet every four hours, so I doubt I get carryover to next day. If I do, I'll take it!

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That is wonderful information! I checked with UT Tyler, and they said that the trial is not open to anyone who is currently taking meds for MAC. That makes sense because they would/could impact trial results, since MAC affects bronchiectasis, and clearing it improves it. After the study is completed and analyzed, that combo will maybe be available to all?

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@irenea8

It is hard to believe that the NAC and Mucinex could get into your system that fast! Maybe some is left over from the previous day. That is alot of water! We sure all have different bodies.

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I don't think they get into the system that fast - I believe that taken daily over time they have a lasting impact on the mucus. For example, if I stop Mucinex, I don't notice the thickening mucus for a day or two. With NAC, I ran out last winter, and noticed a difference after 4 days.
Sue

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I often find when I take something to help with mucus it may not help that day but will the next day.

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@irenea8

I often find when I take something to help with mucus it may not help that day but will the next day.

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That is why I take mine every day, all the time. I started Mucinex first due to persistent ear and sinus infections - who knew it would also be a help with my bronchiectasis years later?

And I started the NAC to help with the mucus, and it has helped with my asthma management & persistent over-reactive inflammatory system. I think it may also be a piece in the puzzle that is helping get my chronic pain under control. Whatever...it helps, has no known bad side effects, and I can afford it, so it is in my meds every day.

I have come to realize that many of the things I do for one problem end up helping others as well. I think that is why health care is such a puzzle, especially as we get older and acquire more and more ailments, diseases, complaints or whatever you want to call them!
Sue

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