Congenital Heart Disease

Welcome to the Congenital Heart Disease (CHD) page. Mayo Clinic has cared for child and adult patients living with CHD for more than 60 years. With extensive expertise in treating people with rare and common congenital heart defects, our medical specialists provide exactly the care you need.

Follow the CHD page and stay up-to-date as we post stories, clinical trials, resources and other useful information to help you and your loved ones along the CHD journey. Post a comment and share your thoughts.

PUBLIC PAGE

Mayo Clinic was one of the first centers to perform congenital heart surgery in North America. As a result, it has one of the largest and oldest cohorts of adults with congenital heart disease. The Adult Congenital Heart Disease Clinic at Mayo Clinic continues to attract referrals from all over the world every year. This robust outpatient practice is ideal for patient recruitment for prospective studies. Additionally, Mayo Clinic has a unique medical records system, containing clinical data accumulated over the last half-century. This feature is invaluable for conducting retrospective patient-oriented research.

 MAYO ADULT CONGENITAL HEART DISEASE (MACHD) BIOBANK

MACHD Registry

 

Thanks to the robust outpatient practice, we were able to create the Mayo Adult Congenital Heart Disease (MACHD) Biobank.  The purpose of this project is the collection, analysis, and cryopreservation of biospecimens from patients with congenital heart disease.  This purpose fits into the overarching mission of the MACHD research program which is ‘to improve the lives of people with congenital heart disease through in-depth understanding of the disease pathophysiology’.

The Biobank is part of a multi-faceted research infrastructure, and is designed to integrate seamlessly with the other existing databases

Please contact Dr. Alexander Egbe for more information about these ongoing prospective studies.

ONGOING PROSPECTIVE STUDIES

Role of Sildenafil for Fontan Associated Liver Disease (SiFALD) Study (NCT03154476)

Eligibility: Fontan palliation

Objective: To determine the role of sildenafil for prevention of liver cirrhosis in Fontan Patients

Enrollment: 09/2016 - 09/2019

 

Occult Arrhythmia and Thromboembolism in Adult Fontan Patients with Cardiac Implantable Electronic Devices

Eligibility: Fontan palliation

Objective: To determine the role of sildenafil for prevention of liver cirrhosis in Fontan Patients

Enrollment: 09/2016 - 09/2019

 

Noninvasive Cardiopulmonary Exercise Testing in Patients with Tetralogy of Fallot (NONINVASIVE-CPETT)

Eligibility: Tetralogy of Fallot

Objective: To determine the hemodynamic mechanisms of exercise intolerance in patients with Tetralogy of Fallot

Enrollment: 07/2017 - 06/2020

 

Noninvasive Assessment of Ventricular and Vascular Function in Patients with Coarctation of Aorta (N-VEVAC)  

Eligibility: Coarctation of aorta

Objective: To determine the hemodynamic mechanisms of exercise intolerance in patients with coarctation of aorta

Enrollment: 07/2017 - 06/2020

 

Assessment of Cardiac Output and Vascular Function Response Using Exercise Echocardiography in Patients with Fontan palliation (COVREEF)

Eligibility: Fontan palliation

Objective: To assess exercise induced heart rate and stroke volume augmentation in patients with Fontan palliation

Enrollment: 07/2017 - 06/2020

 

Invasive Assessment of Ventricular and Vascular Function in Patients with Coarctation of Aorta (I-VEVAC)

Eligibility: Coarctation of aorta and clinical indication for cardiac catheterization

Objective: Simultaneous echo-cardiac catheterization correlation of rest and exercise hemodynamics in patients with coarctation of aorta

Enrollment: 03/2019 - 02/2021

 

Invasive Cardiopulmonary Exercise Testing in Patients with Tetralogy of Fallot (INVASIVE-CPETT)

Eligibility: Tetralogy of Fallot and clinical indication for cardiac catheterization

Objective: Simultaneous echo-cardiac catheterization correlation of rest and exercise hemodynamics in patients with tetralogy of Fallot

Enrollment: 03/2018 - 02/2021

 

Ventricular and Pulmonary Vascular Reserve after the Fontan Operation: Prospective Interventional Study (PVR-Fontan Study)

Eligibility: Fontan palliation and clinical indication for cardiac catheterization

Objective: Simultaneous echo-cardiac catheterization correlation of rest and exercise hemodynamics in patients with Fontan Palliation

Enrollment: 04/2018 - 03/2023

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