Congenital Heart Disease

Welcome to the Congenital Heart Disease (CHD) page. Mayo Clinic has cared for child and adult patients living with CHD for more than 60 years. With extensive expertise in treating people with rare and common congenital heart defects, our medical specialists provide exactly the care you need.

Follow the CHD page and stay up-to-date as we post stories, clinical trials, resources and other useful information to help you and your loved ones along the CHD journey. Post a comment and share your thoughts.


Mayo Clinic was one of the first centers to perform congenital heart surgery in North America. As a result, it has one of the largest and oldest cohorts of adults with congenital heart disease. The Adult Congenital Heart Disease Clinic at Mayo Clinic continues to attract referrals from all over the world every year. This robust outpatient practice is ideal for patient recruitment for prospective studies. Additionally, Mayo Clinic has a unique medical records system, containing clinical data accumulated over the last half-century. This feature is invaluable for conducting retrospective patient-oriented research.

Please contact Dr. Alexander Egbe for more information about these ongoing prospective studies.


Role of Sildenafil for Fontan Associated Liver Disease (SiFALD) Study (NCT03154476)

This is a randomized, double-blind, placebo-controlled study assessing the effect of pulmonary vasodilators in reducing liver stiffness after Fontan palliation.

Status: Enrolling

Fontan Outcomes Study to Improve Transplant Experience and Results (FOSTER) Study

This is a multicenter study involving six Adult Congenital Heart Disease Centers in the United States.

Status: Enrolling

Registry of Efficacy and Safety of Non-vitamin K Antagonist Oral Anticoagulants for Thromboembolic Prevention in Patients with Congenital Heart Disease: The NOTE Registry

This is a multicenter study involving 38 Adult Congenital Heart Disease Centers in North America, Europe and the Netherlands.

Status: Enrolling

Assessment of Splanchnic Circulation in Patients with Fontan Physiology Using 4D Phase Contrast Magnetic Resonance Imaging

Status: Enrolling

Noninvasive Assessment of Cardiac Output in Fontan Patient: A correlation Between Echocardiography and Cardiac MRI

Status: Enrolling

Occult Arrhythmia and Thromboembolism in Adult Fontan Patients with Cardiac Implantable Electronic Devices

Status: Enrolling

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