What are we learning about the role of progesterone in hrt w/o uterus?

Posted by gravity3 @gravity3, 5 days ago

I notice here that most women using hrt/bhrt with progesterone still have a uterus. Has or is the science indicating a change in thinking? What are the main benefits of progesterone and what is the science behind not including it for women with no uterus.

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Dr. Mary Claire Havers has a section on this issue in her book The Pause Life

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I don't think the science hasn't really changed. Progesterone is primarily prescribed to protect the uterine lining in women taking estrogen. Without a uterus, that benefit isn't needed. Some clinicians still prescribe micronized progesterone after hysterectomy for issues like sleep or hot flashes, but that's generally based on symptom management rather than a recommendation that all women without a uterus should take it. Hope that helps.

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Profile picture for babs10 @babs10

I don't think the science hasn't really changed. Progesterone is primarily prescribed to protect the uterine lining in women taking estrogen. Without a uterus, that benefit isn't needed. Some clinicians still prescribe micronized progesterone after hysterectomy for issues like sleep or hot flashes, but that's generally based on symptom management rather than a recommendation that all women without a uterus should take it. Hope that helps.

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@babs10

I am a woman who takes progesterone and I do not have a uterus. My provider strongly advocates for this balance of hormones.
https://www.bodylogicmd.com/blog/the-benefits-of-progesterone-treatment-after-hysterectomy/

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I am hoping that as a group we can address and evaluate the different approaches to this along with our medical providers. Here is more:

For menopausal women without a uterus, progesterone is not medically required to prevent uterine cancer, but it can still provide extra systemic wellness advantages like better sleep, mood stabilization, and bone support. While standard guidelines dictate that estrogen alone is sufficient after a hysterectomy, some patients choose to use progesterone for its extra-uterine actions.Neurological and Mood SupportAnxiety relief: Progesterone breaks down into calming compounds that interact with GABA brain receptors to lower everyday stress and nervous tension.Mood stability: It helps reduce irritability and emotional reactivity during the menopausal transition.Sleep and RestDeeper sleep: Oral micronized progesterone taken at bedtime improves slow-wave deep sleep cycles and helps reduce nighttime waking.Restfulness: The mild sedative effect of the hormone aids overall sleep onset for those dealing with insomnia.Bone and Physical HealthBone formation: Progesterone stimulates osteoblast cells, working alongside estrogen to support bone density and protect against structural weakening.Symptom management: Some women find it offers complementary relief for lingering vasomotor symptoms like mild hot flashes or night sweats.If you are weighing your options for hormone therapy, would you like to discuss:Specific symptoms (like trouble sleeping or anxiety) you are hoping to manage?Potential risks or side effects of adding progesterone?Questions to ask your healthcare provider during your next visit

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Profile picture for gravity3 @gravity3

I am hoping that as a group we can address and evaluate the different approaches to this along with our medical providers. Here is more:

For menopausal women without a uterus, progesterone is not medically required to prevent uterine cancer, but it can still provide extra systemic wellness advantages like better sleep, mood stabilization, and bone support. While standard guidelines dictate that estrogen alone is sufficient after a hysterectomy, some patients choose to use progesterone for its extra-uterine actions.Neurological and Mood SupportAnxiety relief: Progesterone breaks down into calming compounds that interact with GABA brain receptors to lower everyday stress and nervous tension.Mood stability: It helps reduce irritability and emotional reactivity during the menopausal transition.Sleep and RestDeeper sleep: Oral micronized progesterone taken at bedtime improves slow-wave deep sleep cycles and helps reduce nighttime waking.Restfulness: The mild sedative effect of the hormone aids overall sleep onset for those dealing with insomnia.Bone and Physical HealthBone formation: Progesterone stimulates osteoblast cells, working alongside estrogen to support bone density and protect against structural weakening.Symptom management: Some women find it offers complementary relief for lingering vasomotor symptoms like mild hot flashes or night sweats.If you are weighing your options for hormone therapy, would you like to discuss:Specific symptoms (like trouble sleeping or anxiety) you are hoping to manage?Potential risks or side effects of adding progesterone?Questions to ask your healthcare provider during your next visit

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@gravity3, yes, that addresses "symptom management."

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I don't have a uterus and take Progesterone at bedtime. It helps me sleep better, decreases hunger a little, feel calmer and increases my sexual arousal. If any physician declined giving it to you, I'd go find someone else.

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Profile picture for blueskies1530 @blueskies1530

I don't have a uterus and take Progesterone at bedtime. It helps me sleep better, decreases hunger a little, feel calmer and increases my sexual arousal. If any physician declined giving it to you, I'd go find someone else.

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@blueskies1530

I take it already along with estradiol and testosterone. It seems that some are still operating on old info. Progesterone is great.no uterus here!!

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