Waldenstrom Macroglobulinemia with MYD88-wild type
Have recently been diagnosed with above cancer and currently receiving Rituximab, Dexamethasone, Bortezomib. Still early in treatment cycle but no response yet. IgM continues to rise after 3 sessions of plasmapheresis (currently 4,500 mg/dL). The MYD88-wild type complicates treatment options. What are the treatment options for this unmutated WM?