Vaccine against MAC?

Posted by Armando @bolso1, Nov 19, 2020

Does anybody know about a vaccine against MAC? I found the paper ["Protection against Mycobacterium avium by DNA Vaccines Expressing Mycobacterial Antigens as Fusion Proteins with Green Fluorescent Protein" (INFECTION AND IMMUNITY, Aug. 1999, Vol. 67, No. 8 p. 4243–4250)] that claimed to be "…first report of successful DNA vaccination against M. avium", but nothing else.

@sueinmn

Well people, here's our hope for the future! Science is finally beginning to acknowledge the water-borne aspect of MAC/NTM/Pseudomonas and other organisms. https://www.cnn.com/2020/12/16/health/waterborne-diseases-cdc-study-wellness/index.html
With this attention, we could be on our way to recognition of these bio-film supported bacteria, and perhaps a way to break down the biofilm so they can be easily washed away, and not lurk everywhere. Airborne transmission through dust we can more easily manage on our own with masks, filters, etc.
Sue

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Thank you for your posting @sueinmn.
It is indeed perplexing that biofilms have not received the attention that they deserve, considering that it is estimated (Lazar, V. 2011. Quorum sensing in biofilms – How to destroy the bacterial citadels or their cohesion/power? Anaerobe 17 280-285) that they are involved in around 60% of all infections and characterized by moderate intensity symptoms, chronic evolution and resistance to antibiotics.
Mainstream medicine follows mostly a brute force approach to infection management: if it's difficult then double or triple the dose and apply for longer! Fortunately, there are other approached being developed such as bacteriophages and enzymes, that could – hopefully – in the near future compliment antibiotics.

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@bolso1

Thank you for your posting @sueinmn.
It is indeed perplexing that biofilms have not received the attention that they deserve, considering that it is estimated (Lazar, V. 2011. Quorum sensing in biofilms – How to destroy the bacterial citadels or their cohesion/power? Anaerobe 17 280-285) that they are involved in around 60% of all infections and characterized by moderate intensity symptoms, chronic evolution and resistance to antibiotics.
Mainstream medicine follows mostly a brute force approach to infection management: if it's difficult then double or triple the dose and apply for longer! Fortunately, there are other approached being developed such as bacteriophages and enzymes, that could – hopefully – in the near future compliment antibiotics.

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Most perplexing to me is that no one has engineered a replacement for the boiler/water/riser systems almost universally used in taller buildings (apartments & dorms, offices & hotels, hospitals) and ships. These have been proven wells of infection – usually listeria (Legionaires') is the first identified culprit, with MRSA and Pseudomonas aur in hospitals as well. After Covid, as places that sat vacant for a year or more come back on line, growing biofilm and bacteria in their systems, are we going to be in for a mini-epidemic of these infections?
Sue

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