Type 2 Inflammation

Posted by dustbreath @dustbreath, 4 days ago

I have not discussed with my Pulmonologist yet. Will see him at the beginning of May. Constant symptoms with mucus, coughing, breathlessness, heaviness in my chest. I have tried so many types of inhalers that either don’t help much or have awful side effects. My blood work shows a definite pattern for Type 2 Inflammation. Which is why I started researching the Dupixant. Just wonder if anyone can weigh in on this, or has experience with?

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Profile picture for mrmover @mrmover

You must first get a blood test. In order to qualify for Dupixent, you must have raised blood eosinophils.

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@mrmover Not entirely must you have elevated eosinophils, there is also consideration on the treatment that you have been on for exacerbation and been on steroids. Ask your physician if you have any questions about whether you meet the criteria. I did no have elevated eosinophils and have been on dupixent for several years.

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Profile picture for hildacummings80 @hildacummings80

@snoohow many shots did you get before you begin to notice a difference. I took my 4th this wee0k and I don't see a difference. I have asthma and copd

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@hildacummings80 I noticed I was breathing better about the 2nd shot, it just continued. It says it can take a while before you notice and not to quit. I have stage 4 severe emphysema, Half of upper L lobe removed, now scar tissue. Keep taking the shot give it a chance.

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In reply to @hildacummings80 "Thankyou" + (show)
Profile picture for hildacummings80 @hildacummings80

Thankyou so much. What did you feel that it was helping

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Profile picture for mrmover @mrmover

You must first get a blood test. In order to qualify for Dupixent, you must have raised blood eosinophils.

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@mrmover I was breathless just walking around my house , talked with my doctor and told him I need to try something new, I’m on breztri, ohtuvayre, albuterol and still out of breath so he had a lot of blood test done and because I had a lot of white blood cells which cause inflammation I qualified to go on Nacala, same as dupixen both were said good for COPD , had a injection 3 1/2 weeks ago and i actually can walk around my house not being out of breath. It took a while for my insurance to cover it but finally did

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Profile picture for ricktweld @ricktweld

I’m one of the lucky ones. I saw a difference after 3 days, and especially after 2 weeks. I have asthma/ copd also. Ridiculously expensive, but working fantastic for me. I have only used my albuterol a couple of times since starting Dupixent, and I really didn’t need it. Best of luck to you!

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@ricktweld I to am on DUPIXENT, my 7 shot, I don’t have near the mucus and breath better. What were the difference you seen as you continued to take it.

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Profile picture for snoots @snoots

@ricktweld I to am on DUPIXENT, my 7 shot, I don’t have near the mucus and breath better. What were the difference you seen as you continued to take it.

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@snoots i am on my 13th dose. Same results as you and I don’t cough as much and the wheezing is much better. I have been checking my o2 sats for several years now, and I usually average between 92&93 levels. Since starting dupixent, I am measuring between 95&96. Hope this helps you. Good luck!

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I took Dupixent every 2 weeks for 11 months as bd then had to switch to Nucala due to intolerable side effects (muscled & joint pain). My eosinophils as measured by blood test were >500 and I had been having 1-6 exacerbations/year before starting. My resting saturation rates have gone from 92-93 to 96 or so. The Nucala is only every 4 weeks.

I have had to have multiple conversations with CVS specialty pharmacy so they will properly rebill and code. It’s a Medicare B medical coverage and then my insurer will pay the balance. So far so good with Nucala — fingers crossed it continues to work.

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