Switching to Trintellix or Low Dose Naltrexone (LDN)

Posted by elwooodsdad @elwooodsdad, Dec 31, 2018

I have switched from duloxetine to trintillix about 21/2 months ago, and am not adjusting well. Sleep deprivation, mood swings, deeper depression, suicidal thoughts, etc. I’m to see my doctor on 1/2/19, and think switching back to duloxetine would be appropriate. Anyone else with trintillix experience?

@petangelkat1

I have been in Duloxitine for years for fibromyalgia. I don’t know if it’s helping with my depression really. So my doctor added Trintellix as an add on. My complaint before Trintellux was little energy to spring out of bed

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I still am not noticing that the 10mg of Trintellix is helping.

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I added Trintellix starting at 5 mg and up to 20 mg in the last couple of months. In the last 2-3 weeks I’ve noticed my eyes are squinting in the morning. I’ve had to consciously open my eyes and keep them open. I’ve also had a little more agitation and irritability than before the 15 and then 20 mg. I don’t know that the Trintellix is helping my depression and anxiety. My doctor lowered my dosage back to 10 mg. Anyone else have similar experiences?

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@petangelkat1

I added Trintellix starting at 5 mg and up to 20 mg in the last couple of months. In the last 2-3 weeks I’ve noticed my eyes are squinting in the morning. I’ve had to consciously open my eyes and keep them open. I’ve also had a little more agitation and irritability than before the 15 and then 20 mg. I don’t know that the Trintellix is helping my depression and anxiety. My doctor lowered my dosage back to 10 mg. Anyone else have similar experiences?

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My trintillix journey is well documented, but I do feel compelled to address the agitation and irritability issues just noted. According to my wife, whose opinion is important to me, I was a very unpleasant person with whom to live. Meaner than a snake are the words that I recall. I am back to acceptable on Prozac….

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@ethanmcconkey

Hi @elwoodsdad. You may have noticed I moved your discussion from Just Want to Talk to the Depression & Anxiety in hopes that you can connect with others who take this medication. Just click VIEW AND REPLY in your email and you'll be sent to your post.

That must be frustrating to have so many side effects with this medication.

I wanted to introduce you to fellow Connect members @windwalker @depressionsurvivor and @nansmith as they have mentioned this medication in the past.

I also wanted to share this thread on Trintellix and nausea to see if it can be of any help: https://connect.mayoclinic.org/discussion/trintellix-nausea/

It's great that you will be seeing your doctor tomorrow. How long were you on duloxetine before switching?

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Just noticed your question about duloxetine. I took it for 5 or 6 years. I initiated the thought of making a change, believing it to be proactive, as did my doctor. Now much better on Prozac. Amazing what regular sleep does for one. My apologies for my oversight.

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Anyone who Is diagnosed bipolar-polar also take Trintellix?

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@petangelkat1

Anyone who Is diagnosed bipolar-polar also take Trintellix?

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Hi, @petangelkat1 – you might consider asking in the "Bi-polar issues" thread https://connect.mayoclinic.org/discussion/bi-polar-issues/ about whether anyone takes vortioxetine (Trintellix).

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Hi all, I am in between antidepressant meds again.. had to stop Viibrid after a short period of time.. was causing very bad diarrhea.. now Psych is thinking Trintellix.. starting at 5mg. I don't like what i read about it with the side effects.. I also got the GeneSight test and this medicine is not on the Green light list of good meds. for me.. I am also taking avg. 300 mg. Neurontin for cervical neck stenosis nerve pain for about three mos now per my pain management Doctor.. i hate it.. make you feel like a Zombie, good for anxiety some.. the pain management Doctor refusing to do any trigger shots, epidural, etc.. she is stating that it will cause psychosis!! I had nerve blocks, nerve ablations and an epidural for my lower left lumbar spine and that did not happen.. Also, Neurontin can change your mood.. May have to go back on Cymbalta, 20 mg. to help the nerve pain stay under control.. I tried it for a short period of time and it caused upper gastric distress and I believe pretty bad dry eyes.. had to stop it.. I am still on Clonopin- avg 1mg. or more a day or some days none.. These Doctors are driving me nuts with the meds change. I also hate all the lousy side effects.. pain management Doc. also recommending Lyrica and or Norytriptiline and those have bad side effects with major weight gain being one of them. I starve myself now and am never hungry and am at about avg. 158 and 5 ft. 5.5 inches.. way too much for me.. i feel horrible. i am ready to just go off everything!! Any advice would be greatly appreciated.. JMS

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@jeanmnyc

Hi all, I am in between antidepressant meds again.. had to stop Viibrid after a short period of time.. was causing very bad diarrhea.. now Psych is thinking Trintellix.. starting at 5mg. I don't like what i read about it with the side effects.. I also got the GeneSight test and this medicine is not on the Green light list of good meds. for me.. I am also taking avg. 300 mg. Neurontin for cervical neck stenosis nerve pain for about three mos now per my pain management Doctor.. i hate it.. make you feel like a Zombie, good for anxiety some.. the pain management Doctor refusing to do any trigger shots, epidural, etc.. she is stating that it will cause psychosis!! I had nerve blocks, nerve ablations and an epidural for my lower left lumbar spine and that did not happen.. Also, Neurontin can change your mood.. May have to go back on Cymbalta, 20 mg. to help the nerve pain stay under control.. I tried it for a short period of time and it caused upper gastric distress and I believe pretty bad dry eyes.. had to stop it.. I am still on Clonopin- avg 1mg. or more a day or some days none.. These Doctors are driving me nuts with the meds change. I also hate all the lousy side effects.. pain management Doc. also recommending Lyrica and or Norytriptiline and those have bad side effects with major weight gain being one of them. I starve myself now and am never hungry and am at about avg. 158 and 5 ft. 5.5 inches.. way too much for me.. i feel horrible. i am ready to just go off everything!! Any advice would be greatly appreciated.. JMS

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Hi, @jeanmnyc – You may notice I moved your discussion and combined it with another discussion titled, "Trintellix." I did this so other members discussing this medication would see your message and have a chance to add their thoughts.

That is unfortunate you have very bad diarrhea while taking the vilazodone (Viibryd). I'd love for other members who have taken vortioxetine (Trintellix) to weigh in on this medication and how things have gone for them, and offer any advice. Please meet @petangelkat1 @elwooodsdad @rainswuth @ssmm7782 @yudy. @merpreb and @jakedduck1 may also have some input.

@jeanmnyc – just to clarify, have you now started the vortioxetine (Trintellix), or where did you leave things with the doctor about taking this medication?

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@lisalucier

Hi, @jeanmnyc – You may notice I moved your discussion and combined it with another discussion titled, "Trintellix." I did this so other members discussing this medication would see your message and have a chance to add their thoughts.

That is unfortunate you have very bad diarrhea while taking the vilazodone (Viibryd). I'd love for other members who have taken vortioxetine (Trintellix) to weigh in on this medication and how things have gone for them, and offer any advice. Please meet @petangelkat1 @elwooodsdad @rainswuth @ssmm7782 @yudy. @merpreb and @jakedduck1 may also have some input.

@jeanmnyc – just to clarify, have you now started the vortioxetine (Trintellix), or where did you leave things with the doctor about taking this medication?

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I was prescribed trintellix for help with my memory issues and impulsiveness and it was suppose to help which it hasn't. Was bumped up to 10 mg., which was a mistake, stomach issue, felt bad, wanted to do NOTHING. I don't have bi-polar issue, have sleep issue and got addicted to ambien. Have gained 14 lbs. on trintellix and it is very very expensive. Also my ability to focus and get anything done has significantly decreased. Previously, was a type A personality and was very productive. Probably reason I have gained so much weight – just want to sit around and eat. Would never recommend that drug, but I am still on it – 5mg. ……also still taking ambien. We are all different and I just hope someday we can get the right drug or drugs for our DNA or whatever medical community needs to help us. I wish I could feel better so I could get some things done………and not take any drugs.

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In my perfect world we could all have access to a week at one of the Mayo campus locations, and be given a stem to stern going over. Psychiatric help is rudimentary, at best, in many locations. I have good care, but I am concerned for those about whom I read who are being bombarded with a barrage of medications for depression and a whole host of physical issues as well. I question whether or not communication among the specialists exists and am concerned that the cocktail of drugs exacerbates problems, especially the psychological ones. Climbing off my soapbox…I suspect we all need to raise the consciousness of the interdisciplinary medical providers when we are not in a collegial setting such as Mayo. I’m distressed for others. Blessedly, I am a major pain in the butt, and get attention…

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@elwooodsdad

In my perfect world we could all have access to a week at one of the Mayo campus locations, and be given a stem to stern going over. Psychiatric help is rudimentary, at best, in many locations. I have good care, but I am concerned for those about whom I read who are being bombarded with a barrage of medications for depression and a whole host of physical issues as well. I question whether or not communication among the specialists exists and am concerned that the cocktail of drugs exacerbates problems, especially the psychological ones. Climbing off my soapbox…I suspect we all need to raise the consciousness of the interdisciplinary medical providers when we are not in a collegial setting such as Mayo. I’m distressed for others. Blessedly, I am a major pain in the butt, and get attention…

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Amen!

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@lisalucier

Hi, @jeanmnyc – You may notice I moved your discussion and combined it with another discussion titled, "Trintellix." I did this so other members discussing this medication would see your message and have a chance to add their thoughts.

That is unfortunate you have very bad diarrhea while taking the vilazodone (Viibryd). I'd love for other members who have taken vortioxetine (Trintellix) to weigh in on this medication and how things have gone for them, and offer any advice. Please meet @petangelkat1 @elwooodsdad @rainswuth @ssmm7782 @yudy. @merpreb and @jakedduck1 may also have some input.

@jeanmnyc – just to clarify, have you now started the vortioxetine (Trintellix), or where did you leave things with the doctor about taking this medication?

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Hi Linda, Decided not take the Trintellix.. now back on 20 mg. of Cymbalta for now.. so confused as to which med to go on and stay on or get off.. the side effects are so troublesome.. She wanted me to try it.. I don't like what I have been reading about it. Jean

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