Trintellix

Posted by elwooodsdad @elwooodsdad, Dec 31, 2018

I have switched from duloxetine to trintillix about 21/2 months ago, and am not adjusting well. Sleep deprivation, mood swings, deeper depression, suicidal thoughts, etc. I’m to see my doctor on 1/2/19, and think switching back to duloxetine would be appropriate. Anyone else with trintillix experience?

@ethanmcconkey

Hi @elwoodsdad. You may have noticed I moved your discussion from Just Want to Talk to the Depression & Anxiety in hopes that you can connect with others who take this medication. Just click VIEW AND REPLY in your email and you'll be sent to your post.

That must be frustrating to have so many side effects with this medication.

I wanted to introduce you to fellow Connect members @windwalker @depressionsurvivor and @nansmith as they have mentioned this medication in the past.

I also wanted to share this thread on Trintellix and nausea to see if it can be of any help: https://connect.mayoclinic.org/discussion/trintellix-nausea/

It's great that you will be seeing your doctor tomorrow. How long were you on duloxetine before switching?

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Just noticed your question about duloxetine. I took it for 5 or 6 years. I initiated the thought of making a change, believing it to be proactive, as did my doctor. Now much better on Prozac. Amazing what regular sleep does for one. My apologies for my oversight.

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Anyone who Is diagnosed bipolar-polar also take Trintellix?

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@petangelkat1

Anyone who Is diagnosed bipolar-polar also take Trintellix?

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Hi, @petangelkat1 – you might consider asking in the "Bi-polar issues" thread https://connect.mayoclinic.org/discussion/bi-polar-issues/ about whether anyone takes vortioxetine (Trintellix).

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Hi all, I am in between antidepressant meds again.. had to stop Viibrid after a short period of time.. was causing very bad diarrhea.. now Psych is thinking Trintellix.. starting at 5mg. I don't like what i read about it with the side effects.. I also got the GeneSight test and this medicine is not on the Green light list of good meds. for me.. I am also taking avg. 300 mg. Neurontin for cervical neck stenosis nerve pain for about three mos now per my pain management Doctor.. i hate it.. make you feel like a Zombie, good for anxiety some.. the pain management Doctor refusing to do any trigger shots, epidural, etc.. she is stating that it will cause psychosis!! I had nerve blocks, nerve ablations and an epidural for my lower left lumbar spine and that did not happen.. Also, Neurontin can change your mood.. May have to go back on Cymbalta, 20 mg. to help the nerve pain stay under control.. I tried it for a short period of time and it caused upper gastric distress and I believe pretty bad dry eyes.. had to stop it.. I am still on Clonopin- avg 1mg. or more a day or some days none.. These Doctors are driving me nuts with the meds change. I also hate all the lousy side effects.. pain management Doc. also recommending Lyrica and or Norytriptiline and those have bad side effects with major weight gain being one of them. I starve myself now and am never hungry and am at about avg. 158 and 5 ft. 5.5 inches.. way too much for me.. i feel horrible. i am ready to just go off everything!! Any advice would be greatly appreciated.. JMS

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@jeanmnyc

Hi all, I am in between antidepressant meds again.. had to stop Viibrid after a short period of time.. was causing very bad diarrhea.. now Psych is thinking Trintellix.. starting at 5mg. I don't like what i read about it with the side effects.. I also got the GeneSight test and this medicine is not on the Green light list of good meds. for me.. I am also taking avg. 300 mg. Neurontin for cervical neck stenosis nerve pain for about three mos now per my pain management Doctor.. i hate it.. make you feel like a Zombie, good for anxiety some.. the pain management Doctor refusing to do any trigger shots, epidural, etc.. she is stating that it will cause psychosis!! I had nerve blocks, nerve ablations and an epidural for my lower left lumbar spine and that did not happen.. Also, Neurontin can change your mood.. May have to go back on Cymbalta, 20 mg. to help the nerve pain stay under control.. I tried it for a short period of time and it caused upper gastric distress and I believe pretty bad dry eyes.. had to stop it.. I am still on Clonopin- avg 1mg. or more a day or some days none.. These Doctors are driving me nuts with the meds change. I also hate all the lousy side effects.. pain management Doc. also recommending Lyrica and or Norytriptiline and those have bad side effects with major weight gain being one of them. I starve myself now and am never hungry and am at about avg. 158 and 5 ft. 5.5 inches.. way too much for me.. i feel horrible. i am ready to just go off everything!! Any advice would be greatly appreciated.. JMS

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Hi, @jeanmnyc – You may notice I moved your discussion and combined it with another discussion titled, "Trintellix." I did this so other members discussing this medication would see your message and have a chance to add their thoughts.

That is unfortunate you have very bad diarrhea while taking the vilazodone (Viibryd). I'd love for other members who have taken vortioxetine (Trintellix) to weigh in on this medication and how things have gone for them, and offer any advice. Please meet @petangelkat1 @elwooodsdad @rainswuth @ssmm7782 @yudy. @merpreb and @jakedduck1 may also have some input.

@jeanmnyc – just to clarify, have you now started the vortioxetine (Trintellix), or where did you leave things with the doctor about taking this medication?

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@lisalucier

Hi, @jeanmnyc – You may notice I moved your discussion and combined it with another discussion titled, "Trintellix." I did this so other members discussing this medication would see your message and have a chance to add their thoughts.

That is unfortunate you have very bad diarrhea while taking the vilazodone (Viibryd). I'd love for other members who have taken vortioxetine (Trintellix) to weigh in on this medication and how things have gone for them, and offer any advice. Please meet @petangelkat1 @elwooodsdad @rainswuth @ssmm7782 @yudy. @merpreb and @jakedduck1 may also have some input.

@jeanmnyc – just to clarify, have you now started the vortioxetine (Trintellix), or where did you leave things with the doctor about taking this medication?

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I was prescribed trintellix for help with my memory issues and impulsiveness and it was suppose to help which it hasn't. Was bumped up to 10 mg., which was a mistake, stomach issue, felt bad, wanted to do NOTHING. I don't have bi-polar issue, have sleep issue and got addicted to ambien. Have gained 14 lbs. on trintellix and it is very very expensive. Also my ability to focus and get anything done has significantly decreased. Previously, was a type A personality and was very productive. Probably reason I have gained so much weight – just want to sit around and eat. Would never recommend that drug, but I am still on it – 5mg. ……also still taking ambien. We are all different and I just hope someday we can get the right drug or drugs for our DNA or whatever medical community needs to help us. I wish I could feel better so I could get some things done………and not take any drugs.

Liked by Lisa Lucier

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In my perfect world we could all have access to a week at one of the Mayo campus locations, and be given a stem to stern going over. Psychiatric help is rudimentary, at best, in many locations. I have good care, but I am concerned for those about whom I read who are being bombarded with a barrage of medications for depression and a whole host of physical issues as well. I question whether or not communication among the specialists exists and am concerned that the cocktail of drugs exacerbates problems, especially the psychological ones. Climbing off my soapbox…I suspect we all need to raise the consciousness of the interdisciplinary medical providers when we are not in a collegial setting such as Mayo. I’m distressed for others. Blessedly, I am a major pain in the butt, and get attention…

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@elwooodsdad

In my perfect world we could all have access to a week at one of the Mayo campus locations, and be given a stem to stern going over. Psychiatric help is rudimentary, at best, in many locations. I have good care, but I am concerned for those about whom I read who are being bombarded with a barrage of medications for depression and a whole host of physical issues as well. I question whether or not communication among the specialists exists and am concerned that the cocktail of drugs exacerbates problems, especially the psychological ones. Climbing off my soapbox…I suspect we all need to raise the consciousness of the interdisciplinary medical providers when we are not in a collegial setting such as Mayo. I’m distressed for others. Blessedly, I am a major pain in the butt, and get attention…

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Amen!

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@lisalucier

Hi, @jeanmnyc – You may notice I moved your discussion and combined it with another discussion titled, "Trintellix." I did this so other members discussing this medication would see your message and have a chance to add their thoughts.

That is unfortunate you have very bad diarrhea while taking the vilazodone (Viibryd). I'd love for other members who have taken vortioxetine (Trintellix) to weigh in on this medication and how things have gone for them, and offer any advice. Please meet @petangelkat1 @elwooodsdad @rainswuth @ssmm7782 @yudy. @merpreb and @jakedduck1 may also have some input.

@jeanmnyc – just to clarify, have you now started the vortioxetine (Trintellix), or where did you leave things with the doctor about taking this medication?

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Hi Linda, Decided not take the Trintellix.. now back on 20 mg. of Cymbalta for now.. so confused as to which med to go on and stay on or get off.. the side effects are so troublesome.. She wanted me to try it.. I don't like what I have been reading about it. Jean

Liked by Lisa Lucier

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@jeanmnyc

Hi Linda, Decided not take the Trintellix.. now back on 20 mg. of Cymbalta for now.. so confused as to which med to go on and stay on or get off.. the side effects are so troublesome.. She wanted me to try it.. I don't like what I have been reading about it. Jean

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Is your physician suggesting you just try the Trintellix a general practitioner or board certified in psychiatric medicine? The just try it school of prescribing distresses me for you and countless others. Trintellix is relatively new, and being heavily promoted to the medical community, and to the general population. I hope whoever suggests it has familiarity with patient experience. It is terribly expensive. When it works, it is said to be the holy grail. When it doesn’t, it provided a very unsatisfactory result.

Liked by jeanmnyc

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@elwooodsdad

Is your physician suggesting you just try the Trintellix a general practitioner or board certified in psychiatric medicine? The just try it school of prescribing distresses me for you and countless others. Trintellix is relatively new, and being heavily promoted to the medical community, and to the general population. I hope whoever suggests it has familiarity with patient experience. It is terribly expensive. When it works, it is said to be the holy grail. When it doesn’t, it provided a very unsatisfactory result.

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Hi,

She is a board certified Psychiatrist. I am beginning to think she is just grasping at straws.. I have been on quite a few meds.. I went off Pristiq after about a year or more at the end of December.. Hell to get off of.. I was on avg. dose of 25 mg.. had been up to 50 mg… Before that I was on just reg. Effexor,non XR.. 25- 50 mg.. reduced it to 25 mg.. sick of being FAT and eating nothing.. lost about 20 lbs.. but mood and cognition suffered.. she suggested Pristiq, as it is similar.. I was having terrible night sweats, some aggression, feeling numb, taking naps.. Then the cervical neck stenosis diagnosis was confirmed in early Dec. on MRI.. I did a trial of Cymbalta from late Feb.- early March.. It caused dry eyes, upper GI trouble, bad insomnia.. it did help the nerve pain some. I am also still on the Neurontin, usually at night, 300 mg. for the darn nerve pain.. I hate it. I am also on Clonopin, avg1mg- 2mg. a day.

Sorry I ever took the Clonopin 26 years ago after a perm. job loss..

It is horrible and messes up your personality and your cognition.

Now today, after restarting the Cymbalta, 20 mg. on Sat. 4/27 for 3 days, I stopped today to see if the insomnia gets better, the dry eyes..the more irritability. Also made my constipation worse and I have bad IBS- Small intestinal bacterial overgrowth with Constipation and take Trulance for that..

You literally do not want to eat much of anything while on Cymbalta and it does cause bad upper dyspepsia.

I know also the Neurontin causes a lot of side effects..

I am at a real crossroads on what to go on next, if anything.

I had the Genesight testing in November.

Wellbutrin and Pristiq and Viibrid are in the green column.

I have been on and off different meds. since 10/96..

I am a heavy anorexic now from all these meds..

I hardly eat.

Wt. about 158 at 5 ft. 5.5 inches..

My nerves are shot all around from the major stressors I am enduring with no end in sight.

I think Trintellix looks pretty dangerous to me and it was 'Brintellix" years ago.. they had to rename it due to it was too similar to another RX name..

The nerve pain and cervical neck stenosis has made this whole thing worse about which antidepressant to go on and stay on.

Also researching Cymbalta and hard to get off of and some people have gained a lot of weight on it..

Makes me not want to take anything ever again..

Jean

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@jeanmnyc

Hi,

She is a board certified Psychiatrist. I am beginning to think she is just grasping at straws.. I have been on quite a few meds.. I went off Pristiq after about a year or more at the end of December.. Hell to get off of.. I was on avg. dose of 25 mg.. had been up to 50 mg… Before that I was on just reg. Effexor,non XR.. 25- 50 mg.. reduced it to 25 mg.. sick of being FAT and eating nothing.. lost about 20 lbs.. but mood and cognition suffered.. she suggested Pristiq, as it is similar.. I was having terrible night sweats, some aggression, feeling numb, taking naps.. Then the cervical neck stenosis diagnosis was confirmed in early Dec. on MRI.. I did a trial of Cymbalta from late Feb.- early March.. It caused dry eyes, upper GI trouble, bad insomnia.. it did help the nerve pain some. I am also still on the Neurontin, usually at night, 300 mg. for the darn nerve pain.. I hate it. I am also on Clonopin, avg1mg- 2mg. a day.

Sorry I ever took the Clonopin 26 years ago after a perm. job loss..

It is horrible and messes up your personality and your cognition.

Now today, after restarting the Cymbalta, 20 mg. on Sat. 4/27 for 3 days, I stopped today to see if the insomnia gets better, the dry eyes..the more irritability. Also made my constipation worse and I have bad IBS- Small intestinal bacterial overgrowth with Constipation and take Trulance for that..

You literally do not want to eat much of anything while on Cymbalta and it does cause bad upper dyspepsia.

I know also the Neurontin causes a lot of side effects..

I am at a real crossroads on what to go on next, if anything.

I had the Genesight testing in November.

Wellbutrin and Pristiq and Viibrid are in the green column.

I have been on and off different meds. since 10/96..

I am a heavy anorexic now from all these meds..

I hardly eat.

Wt. about 158 at 5 ft. 5.5 inches..

My nerves are shot all around from the major stressors I am enduring with no end in sight.

I think Trintellix looks pretty dangerous to me and it was 'Brintellix" years ago.. they had to rename it due to it was too similar to another RX name..

The nerve pain and cervical neck stenosis has made this whole thing worse about which antidepressant to go on and stay on.

Also researching Cymbalta and hard to get off of and some people have gained a lot of weight on it..

Makes me not want to take anything ever again..

Jean

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@jeanmnyc Welcome to connect we aren't Dr,s but help where we can. You sound like me sensitive to meds. That's why I decided for myself to study vit.min.herbsand homeopathic medicine ,no side effects. The book I have I like is Phyllis Bach it's her 5th edition. I do alot of research as we know our bodies better then Dr,s we all need to be our on advocate Sometimes Dr,s will pigeonhole patients thinking this pill will help everyone that's not the case Hope you find something to help you ,this is just what helps me

Liked by jeanmnyc

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@petangelkat1

I added Trintellix starting at 5 mg and up to 20 mg in the last couple of months. In the last 2-3 weeks I’ve noticed my eyes are squinting in the morning. I’ve had to consciously open my eyes and keep them open. I’ve also had a little more agitation and irritability than before the 15 and then 20 mg. I don’t know that the Trintellix is helping my depression and anxiety. My doctor lowered my dosage back to 10 mg. Anyone else have similar experiences?

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Hi, @petangelkat1 – you'd mentioned some potential side effects you were experiencing from taking the vortioxetine (Trintellix). Just wondering how it's going lately with that medication?

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I only noticed today that there is this thread on Trintellix. I have a few comments that might be of relevance. I am surprised to see the range of indications for which people are being given this drug. I thought it was approved only for adults with MDD (Major Depressive Disorder) unlike duloxetine which is approved for a wide range of indications. Furthermore, as an anti depressant duloxetine is a SNRI (serotonin-norepinephrine reuptake inhibitor) antidepressant while Trintellix is a SSRI (selective serotonin reuptake inhibitor ) antidepressant. Like all antidepressives both these drugs have a wide range of possible side effects and because it takes a few weeks for these drugs to "work" we often experience debilitating side effects before any therapeutic benefits are observed.

Personally I seem to suffer side effects with most drugs and was on several antidepressives (that I couldn't tolerate) for very severe MDD before being put on 10 mg daily of Trintellix. I had no noticeable side effects and after six months my MDD was under control and after a year or so I had no symptoms at all. Now I don't know if that was due to Trintellix or to the practice of mindful meditation and exercise (recumbent Trike) that I started at the same time. After three years I am still on Trintellix (and meditation and exercise) and still have no depression. I do occasionally have transient anxiety episodes but again mindful meditation helps me to "accept" them.

It seems that selecting antidepressants is very unscientific (unless you go to a place like the Mayo Clinic) and I understand from personal experience how frustrating it is to be bombbarded with horrible side effects at the very time when you may feel hopeless, useless and suicidal. However, for what it is worth from my experience I would recommend relying upon yourself, friends and informative web sites even more than your doctors. Lets face it, our doctors have limited time and must get fed up with endless complaints about side effects. And finally, yes some medications help some people some of the time BUT social activities, attention to diet, mindfulness, and exercise can help all of us all of the time, even when we are not depressed!

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