Switching to Trintellix or Low Dose Naltrexone (LDN)

Posted by elwooodsdad @elwooodsdad, Dec 31, 2018

I have switched from duloxetine to trintillix about 21/2 months ago, and am not adjusting well. Sleep deprivation, mood swings, deeper depression, suicidal thoughts, etc. I’m to see my doctor on 1/2/19, and think switching back to duloxetine would be appropriate. Anyone else with trintillix experience?

@jeanmnyc

Hi Linda, Decided not take the Trintellix.. now back on 20 mg. of Cymbalta for now.. so confused as to which med to go on and stay on or get off.. the side effects are so troublesome.. She wanted me to try it.. I don't like what I have been reading about it. Jean

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Is your physician suggesting you just try the Trintellix a general practitioner or board certified in psychiatric medicine? The just try it school of prescribing distresses me for you and countless others. Trintellix is relatively new, and being heavily promoted to the medical community, and to the general population. I hope whoever suggests it has familiarity with patient experience. It is terribly expensive. When it works, it is said to be the holy grail. When it doesn’t, it provided a very unsatisfactory result.

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@elwooodsdad

Is your physician suggesting you just try the Trintellix a general practitioner or board certified in psychiatric medicine? The just try it school of prescribing distresses me for you and countless others. Trintellix is relatively new, and being heavily promoted to the medical community, and to the general population. I hope whoever suggests it has familiarity with patient experience. It is terribly expensive. When it works, it is said to be the holy grail. When it doesn’t, it provided a very unsatisfactory result.

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Hi,

She is a board certified Psychiatrist. I am beginning to think she is just grasping at straws.. I have been on quite a few meds.. I went off Pristiq after about a year or more at the end of December.. Hell to get off of.. I was on avg. dose of 25 mg.. had been up to 50 mg… Before that I was on just reg. Effexor,non XR.. 25- 50 mg.. reduced it to 25 mg.. sick of being FAT and eating nothing.. lost about 20 lbs.. but mood and cognition suffered.. she suggested Pristiq, as it is similar.. I was having terrible night sweats, some aggression, feeling numb, taking naps.. Then the cervical neck stenosis diagnosis was confirmed in early Dec. on MRI.. I did a trial of Cymbalta from late Feb.- early March.. It caused dry eyes, upper GI trouble, bad insomnia.. it did help the nerve pain some. I am also still on the Neurontin, usually at night, 300 mg. for the darn nerve pain.. I hate it. I am also on Clonopin, avg1mg- 2mg. a day.

Sorry I ever took the Clonopin 26 years ago after a perm. job loss..

It is horrible and messes up your personality and your cognition.

Now today, after restarting the Cymbalta, 20 mg. on Sat. 4/27 for 3 days, I stopped today to see if the insomnia gets better, the dry eyes..the more irritability. Also made my constipation worse and I have bad IBS- Small intestinal bacterial overgrowth with Constipation and take Trulance for that..

You literally do not want to eat much of anything while on Cymbalta and it does cause bad upper dyspepsia.

I know also the Neurontin causes a lot of side effects..

I am at a real crossroads on what to go on next, if anything.

I had the Genesight testing in November.

Wellbutrin and Pristiq and Viibrid are in the green column.

I have been on and off different meds. since 10/96..

I am a heavy anorexic now from all these meds..

I hardly eat.

Wt. about 158 at 5 ft. 5.5 inches..

My nerves are shot all around from the major stressors I am enduring with no end in sight.

I think Trintellix looks pretty dangerous to me and it was 'Brintellix" years ago.. they had to rename it due to it was too similar to another RX name..

The nerve pain and cervical neck stenosis has made this whole thing worse about which antidepressant to go on and stay on.

Also researching Cymbalta and hard to get off of and some people have gained a lot of weight on it..

Makes me not want to take anything ever again..

Jean

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@jeanmnyc

Hi,

She is a board certified Psychiatrist. I am beginning to think she is just grasping at straws.. I have been on quite a few meds.. I went off Pristiq after about a year or more at the end of December.. Hell to get off of.. I was on avg. dose of 25 mg.. had been up to 50 mg… Before that I was on just reg. Effexor,non XR.. 25- 50 mg.. reduced it to 25 mg.. sick of being FAT and eating nothing.. lost about 20 lbs.. but mood and cognition suffered.. she suggested Pristiq, as it is similar.. I was having terrible night sweats, some aggression, feeling numb, taking naps.. Then the cervical neck stenosis diagnosis was confirmed in early Dec. on MRI.. I did a trial of Cymbalta from late Feb.- early March.. It caused dry eyes, upper GI trouble, bad insomnia.. it did help the nerve pain some. I am also still on the Neurontin, usually at night, 300 mg. for the darn nerve pain.. I hate it. I am also on Clonopin, avg1mg- 2mg. a day.

Sorry I ever took the Clonopin 26 years ago after a perm. job loss..

It is horrible and messes up your personality and your cognition.

Now today, after restarting the Cymbalta, 20 mg. on Sat. 4/27 for 3 days, I stopped today to see if the insomnia gets better, the dry eyes..the more irritability. Also made my constipation worse and I have bad IBS- Small intestinal bacterial overgrowth with Constipation and take Trulance for that..

You literally do not want to eat much of anything while on Cymbalta and it does cause bad upper dyspepsia.

I know also the Neurontin causes a lot of side effects..

I am at a real crossroads on what to go on next, if anything.

I had the Genesight testing in November.

Wellbutrin and Pristiq and Viibrid are in the green column.

I have been on and off different meds. since 10/96..

I am a heavy anorexic now from all these meds..

I hardly eat.

Wt. about 158 at 5 ft. 5.5 inches..

My nerves are shot all around from the major stressors I am enduring with no end in sight.

I think Trintellix looks pretty dangerous to me and it was 'Brintellix" years ago.. they had to rename it due to it was too similar to another RX name..

The nerve pain and cervical neck stenosis has made this whole thing worse about which antidepressant to go on and stay on.

Also researching Cymbalta and hard to get off of and some people have gained a lot of weight on it..

Makes me not want to take anything ever again..

Jean

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@jeanmnyc Welcome to connect we aren't Dr,s but help where we can. You sound like me sensitive to meds. That's why I decided for myself to study vit.min.herbsand homeopathic medicine ,no side effects. The book I have I like is Phyllis Bach it's her 5th edition. I do alot of research as we know our bodies better then Dr,s we all need to be our on advocate Sometimes Dr,s will pigeonhole patients thinking this pill will help everyone that's not the case Hope you find something to help you ,this is just what helps me

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@petangelkat1

I added Trintellix starting at 5 mg and up to 20 mg in the last couple of months. In the last 2-3 weeks I’ve noticed my eyes are squinting in the morning. I’ve had to consciously open my eyes and keep them open. I’ve also had a little more agitation and irritability than before the 15 and then 20 mg. I don’t know that the Trintellix is helping my depression and anxiety. My doctor lowered my dosage back to 10 mg. Anyone else have similar experiences?

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Hi, @petangelkat1 – you'd mentioned some potential side effects you were experiencing from taking the vortioxetine (Trintellix). Just wondering how it's going lately with that medication?

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I only noticed today that there is this thread on Trintellix. I have a few comments that might be of relevance. I am surprised to see the range of indications for which people are being given this drug. I thought it was approved only for adults with MDD (Major Depressive Disorder) unlike duloxetine which is approved for a wide range of indications. Furthermore, as an anti depressant duloxetine is a SNRI (serotonin-norepinephrine reuptake inhibitor) antidepressant while Trintellix is a SSRI (selective serotonin reuptake inhibitor ) antidepressant. Like all antidepressives both these drugs have a wide range of possible side effects and because it takes a few weeks for these drugs to "work" we often experience debilitating side effects before any therapeutic benefits are observed.

Personally I seem to suffer side effects with most drugs and was on several antidepressives (that I couldn't tolerate) for very severe MDD before being put on 10 mg daily of Trintellix. I had no noticeable side effects and after six months my MDD was under control and after a year or so I had no symptoms at all. Now I don't know if that was due to Trintellix or to the practice of mindful meditation and exercise (recumbent Trike) that I started at the same time. After three years I am still on Trintellix (and meditation and exercise) and still have no depression. I do occasionally have transient anxiety episodes but again mindful meditation helps me to "accept" them.

It seems that selecting antidepressants is very unscientific (unless you go to a place like the Mayo Clinic) and I understand from personal experience how frustrating it is to be bombbarded with horrible side effects at the very time when you may feel hopeless, useless and suicidal. However, for what it is worth from my experience I would recommend relying upon yourself, friends and informative web sites even more than your doctors. Lets face it, our doctors have limited time and must get fed up with endless complaints about side effects. And finally, yes some medications help some people some of the time BUT social activities, attention to diet, mindfulness, and exercise can help all of us all of the time, even when we are not depressed!

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@alamogal635

Is anyone taking, or familiar with Trintellix? I have been taking Fluoxetine for years and my psychiatrist and I thought I might try this instead. As I read about this I become more and more reluctant to try it due to the many reports of nausea especially and eye troubles as well. I’d appreciate any information anyone on this site has. Thank you.

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Changing drugs is a roll of the dice. I was on Cymbalta, and discussed a possible change as the benefit was diminished. My psychiatrist suggested that Trintellix was reputed to be the latest and greatest, so we tried it. (For context, this was 18 months ago.) I did poorly on Trintellix. Mood and disposition were not good, and suicidal ideation was also a larger issue than before. As a sidebar, Trintellix is very expensive, so paying a premium to feel worse was even more unattractive. Tapered off Trintellix with a combination of clonazepam, and a therapeutic dose of Prozac.

That’s my story, and of course your mileage may vary. Trintellix is, I believe, a good drug for some, but not for all, and certainly not for me. I gave it a couple of months, but it wasn’t meant to be. We are all different.

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@alamogal635

Is anyone taking, or familiar with Trintellix? I have been taking Fluoxetine for years and my psychiatrist and I thought I might try this instead. As I read about this I become more and more reluctant to try it due to the many reports of nausea especially and eye troubles as well. I’d appreciate any information anyone on this site has. Thank you.

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My depression remains a constant in my life (feel no joy) along with anxiety and lately a few panic attacks. My system is sensitive to medications and have tried numerous meds with numerous side effects, but depression is so unrelenting that new meds have been suggested. Does anyone have any experience or knowledge with everything either Trintellix or LDN? Have done some research, but would appreciate some feedback. Thanks

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Is anyone taking, or familiar with Trintellix? I have been taking Fluoxetine for years and my psychiatrist and I thought I might try this instead. As I read about this I become more and more reluctant to try it due to the many reports of nausea especially and eye troubles as well. I’d appreciate any information anyone on this site has. Thank you.

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Hi @marjou and @alamogal635, I moved your messages about Trintellix (low dose naltrexone or LDN) to this existing discussion about the drug so that you could read the experiences of other members like @elwooodsdad @petangelkat1 @jeanmnyc @rachel123 @marazion and others.

@alamogal635 did you make the switch?

@marjou if you are sensitive to medications and have tried several, have you ever considered genetic testing?
You can read more about it and people's experiences in this discussion:
– Why Genetic Testing for Mental Health Meds is Important https://connect.mayoclinic.org/discussion/why-genetic-testing-for-mental-health-meds-is-important/

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Not aware of this genetic testing. The list of meds I've tried is so long that most doctors have given up. Thanks for info.

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@colleenyoung

Hi @marjou and @alamogal635, I moved your messages about Trintellix (low dose naltrexone or LDN) to this existing discussion about the drug so that you could read the experiences of other members like @elwooodsdad @petangelkat1 @jeanmnyc @rachel123 @marazion and others.

@alamogal635 did you make the switch?

@marjou if you are sensitive to medications and have tried several, have you ever considered genetic testing?
You can read more about it and people's experiences in this discussion:
– Why Genetic Testing for Mental Health Meds is Important https://connect.mayoclinic.org/discussion/why-genetic-testing-for-mental-health-meds-is-important/

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The reference input you provided helped in my decision not to try Trintellex. Thank you.

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@alamogal635

Is anyone taking, or familiar with Trintellix? I have been taking Fluoxetine for years and my psychiatrist and I thought I might try this instead. As I read about this I become more and more reluctant to try it due to the many reports of nausea especially and eye troubles as well. I’d appreciate any information anyone on this site has. Thank you.

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Have read some other posts an Trintellix which cost and bad side effects helps me to determine not to try it for me.

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