Treatment of lung adenocarcinoma

@mangolinda8191 Oncologist appointment was all "regular"... according to him and the Oncology Pharmacist, my labs have no problem with continuation of Tepmetko. I have started having edema in my lower legs and feet. I sleep with my feet elevated slightly so in the morning, the edema is gone; it develops during the day. Is this a precursor for it getting much worse? The skin on my lower legs is very fragile (due to lots of skin cancer removals) and I'm paranoid about future possiblity of skin splitting. (Advice to self: stop worrying about future possibilities!)

@mangolinda8191 , Sometimes our bodies need time to adjust to medications, but this swelling sounds difficult too. It's been a few days since you posted this update. Has there been any change? Don't be shy about reaching out to your oncologist to keep them updated if things continue to get worse.

I’m just getting ready to start taking Tagrisso … I’m encouraged you and Frank are tolerating it well for 5-10 years! 🙏

My mother started taking osimertinib. Two weeks later, her platelet count dropped from 150 to 100. Forty days after that, she suffered a myocardial infarction. Her platelet count has now fallen to just over 50. Osimertinib has been discontinued. I would like to know if she can resume this medication in the future.

With all due respect I would never give anyone a drug that caused such life threatening symptoms, you’re blessed that she survived this horrific event. I understand that you want to do what’s best for her but there’s many other options that you can speak to your doctor about, these medications can do good things for some people but they also can cause life threatening symptoms. It’s really in your mother’s best interest and your own peace of mind to take this serious issue to her doctors who know what is best for her.

@tongxiaozhi, that's certainly a scary reaction. Has she stabilized now, and is she feeling better?
Do her doctors believe it was the medication, or some other cause for these events? Some people do well on a lower than standard dose of the targeted therapy medications, but it's certainly best for her doctors to determine what's best. Are you and your family able to help her through this illness? It has to be a difficult time for all of you.

@frouke Many thanks for your reply. We took osimertinib for two weeks and did a follow-up check. The blood routine and liver function were both normal, but the platelet count dropped from 150 to 100. After continuing the medication for another month, she caught a cold during that period. One day she suddenly vomited, and at night we sent her to the hospital. The doctor said it was an acute myocardial infarction.

Angiography showed a large thrombus in the coronary artery. The doctor said the main cause was still atherosclerosis. In addition, my mother had two previous mild strokes and has been taking antihypertensive medication continuously.

Now she is hospitalized for further tests, and her liver function is also abnormal. The doctor said it may be due to osimertinib; however, the doctor also said that the main cause of the myocardial infarction was not osimertinib, but that it may have had some contributing effect.

After the heart attack, her platelet count dropped to just over 50. It is unclear whether this is due to the myocardial infarction or the effect of osimertinib

@lls8000 Thanks for your reply and your kind words of comfort.

She is awake and feeling better now. The doctor believed that Osimertinib was not the main cause. My family are taking care my mom well. We will discontnued Osimertinib for a while and re-evaluate the possiblity of restarting it after two weeks.

We took osimertinib for two weeks and did a follow-up check. The blood routine and liver function were both normal, but the platelet count dropped from 150 to 100. After continuing the medication for another month, she caught a cold during that period. One day she suddenly vomited, and at night we sent her to the hospital. The doctor said it was an acute myocardial infarction.

Angiography showed a large thrombus in the coronary artery. The doctor said the main cause was still atherosclerosis. In addition, my mother had two previous mild strokes and has been taking antihypertensive medication continuously.

Now she is hospitalized for further tests, and her liver function is also abnormal. The doctor said it may be due to osimertinib; however, the doctor also said that the main cause of the myocardial infarction was not osimertinib, but that it may have had some contributing effect.

After the heart attack, her platelet count dropped to just over 50. It is unclear whether this is due to the myocardial infarction or the effect of osimertinib