@mangolinda8191 Oncologist appointment was all "regular"... according to him and the Oncology Pharmacist, my labs have no problem with continuation of Tepmetko. I have started having edema in my lower legs and feet. I sleep with my feet elevated slightly so in the morning, the edema is gone; it develops during the day. Is this a precursor for it getting much worse? The skin on my lower legs is very fragile (due to lots of skin cancer removals) and I'm paranoid about future possiblity of skin splitting. (Advice to self: stop worrying about future possibilities!)