1. < Breast Cancer

Something new in the treatment arsenal?

Posted by nlb122 @nlb122, Sep 23, 2023

AstraZeneca reported positive results from a Phase 3 trial for a breast- cancer treatment, sending its American depositary receipts higher.

Shares of AstraZeneca (ticker: AZN) were up 1.7% to $68.16 in morning trading.

The company said the trial showed that the treatment, datopotamab deruxtecan, showed a significant improvement relative to chemotherapy in terms of progression-free survival. Plans to submit the drug for regulatory approval globally are underway.

Progression-free survival “is defined as the time from random assignment in a clinical trial to disease progression or death from any cause,” according to the National Library of Medicine.

Interested in more discussions like this? Go to the Breast Cancer Support Group.

Zebra | @californiazebra | Dec 10, 2023
In reply to @leeann66 "Hello! I have one November 27 so will know about a week after that. I am..." + (show)
@leeann66

Hello! I have one November 27 so will know about a week after that. I am feeling well! Had one cycle
That I felt like I was getting a flu the whole
Time but was just very run down I think as all good now and back to normal. A few exhausted achy days post chemo but otherwise good and living my life! Reach out and remind me after first week of December for scan news! Hope you are well!

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@leeann66
How did your scan come out? Hoping you're still having favorable results with Tropion. Looking forward to an update. Zebra

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leeann66 | @leeann66 | Dec 11, 2023

Hello! Yes I got the results and everything is still stable, no changes meaning no new lesions, cancer not seen in all
The previous places, still
Showing in the lymph nodes but has not changed in size for 6 months. (Initially they shrunk to half the size but have not changed since!). Overall very good news!!!! Thanks for checking in! 😀

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1 reply
Zebra | @californiazebra | Dec 11, 2023
In reply to @leeann66 "Hello! Yes I got the results and everything is still stable, no changes meaning no new..." + (show)
@leeann66

Hello! Yes I got the results and everything is still stable, no changes meaning no new lesions, cancer not seen in all
The previous places, still
Showing in the lymph nodes but has not changed in size for 6 months. (Initially they shrunk to half the size but have not changed since!). Overall very good news!!!! Thanks for checking in! 😀

Jump to this post

Greats news that the trial is going so well for you!!! Thanks for the update. Prayers for continued success!!!

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leolion811 | @leolion811 | Jan 3 9:59am

Anything new for TNBC? Thank you.

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drummergirl | @drummergirl | Jan 4 8:33am

Nlb122– what type of breast cancer are you being treated for?

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vicsmit | @vicsmit | Jan 5 1:20pm
In reply to @nlb122 "Unfortunately, I have no additional information as this announcement was from a financial resource rather than..." + (show)
@nlb122

Unfortunately, I have no additional information as this announcement was from a financial resource rather than health care site. I do follow the ASCO post online and under the News heading, it does show FDA approval for 4 new treatments and details for use. The more we know helps us sort thru decisions for the future. Hope this helps a bit.

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I have HR+ HER2- mbc and had been on Verzenio for 6 months then Abraxane chemo for 6 months before each began losing effectiveness. My oncologist is prescribing a newly approved immunotherapy pill called Truqap produced by AstraZenica. I have not started this treatment yet but reading indicates side effects similar to Verzenio et al. My oncologist said Truqap is not in the same family as Verzenio et al though. As a side note, I was also in a Kisqali trial during 2019-2020 before losing my eyesight to corneal damage caused by bacterial infections in each eye 6 months apart (I add this to warn users to be aware of any eye sensitivity and see your optometrist immediately). Here is a link to more information on Truqap https://www.astrazeneca.com/media-centre/press-releases/2023/truqap-approved-in-us-for-hr-plus-breast-cancer.html

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1 reply
Zebra | @californiazebra | Apr 12 1:51pm

Hi @leeann66 The last post I see from you is 4 months ago. Are things still going well in the clinical trial? I would love to hear an update on how you're doing. Zebra

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1 reply
leeann66 | @leeann66 | Apr 13 7:55am
In reply to @californiazebra "Hi @leeann66 The last post I see from you is 4 months ago. Are things still..." + (show)
@californiazebra

Hi @leeann66 The last post I see from you is 4 months ago. Are things still going well in the clinical trial? I would love to hear an update on how you're doing. Zebra

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Hello, yes all is well! I was
Locked out of this channel
For awhile so was not responding or commenting.

Just had a scan yesterday so will know if all is still stable.

I don’t remember my last update however side effects, specifically my eyes and mouth and more fatigue.

My “dry eye”
Kept getting worse and worse so I pushed for further testing and was diagnosed with Limbal Stem Cell Deficiency caused by the chemo. On special eye drops made from the plasma from my own blood (pretty cool) since end of January and seeing slow progress, but still progress! (Maybe I already shared that here???)

Mouth sores, well that also got worse and I am expecting a new diagnosis on that also (following my constant research to find solutions and sharing my findings with my medical team!). All issues chemo related!!

Anyways, I have no reason to believe the cancer is not still stable and will know for sure this coming week! 🤞🏻

I also saw that Dato-Dxd was being put forward in the US for FDA approval so will soon be available for everyone!

If you have any specific questions please reach out to me I’d be happy to share!

Thanks for reaching out, will try to remember my password moving forward so I can continue to be active in this forum! 😀

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2 replies
Zebra | @californiazebra | Apr 13 3:01pm
In reply to @leeann66 "Hello, yes all is well! I was Locked out of this channel For awhile so was..." + (show)
@leeann66

Hello, yes all is well! I was
Locked out of this channel
For awhile so was not responding or commenting.

Just had a scan yesterday so will know if all is still stable.

I don’t remember my last update however side effects, specifically my eyes and mouth and more fatigue.

My “dry eye”
Kept getting worse and worse so I pushed for further testing and was diagnosed with Limbal Stem Cell Deficiency caused by the chemo. On special eye drops made from the plasma from my own blood (pretty cool) since end of January and seeing slow progress, but still progress! (Maybe I already shared that here???)

Mouth sores, well that also got worse and I am expecting a new diagnosis on that also (following my constant research to find solutions and sharing my findings with my medical team!). All issues chemo related!!

Anyways, I have no reason to believe the cancer is not still stable and will know for sure this coming week! 🤞🏻

I also saw that Dato-Dxd was being put forward in the US for FDA approval so will soon be available for everyone!

If you have any specific questions please reach out to me I’d be happy to share!

Thanks for reaching out, will try to remember my password moving forward so I can continue to be active in this forum! 😀

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Hi @leeann66
Thank you for the update! Prayers for your scan results! Please update when those come in. It sounds like you're still in good spirits despite some challenging side effects. Yes, neat how they are treating your eyes. New treatments all the time. Also good news that they are submitting Dato-Dxd for FDA approval. Your results to date are encouraging!

Since you're so great about answering questions:

Do they expect you to remain on Dato-Dxd indefinitely or only when there are visual signs of cancer?

Have there been any issues with Dato-Dxd causing peripheral neuropathy as many chemos do?

For perspective, how much does this treatment impact your quality of life compared to the other treatment regimens you've tried (Kisqali/anastrozole, afinitor/exemastane, xeloda)?

Thank you for taking the time to respond. Please keep us posted. Zebra

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1 reply
Zebra | @californiazebra | Apr 13 3:16pm
In reply to @vicsmit "I have HR+ HER2- mbc and had been on Verzenio for 6 months then Abraxane chemo..." + (show)
@vicsmit

I have HR+ HER2- mbc and had been on Verzenio for 6 months then Abraxane chemo for 6 months before each began losing effectiveness. My oncologist is prescribing a newly approved immunotherapy pill called Truqap produced by AstraZenica. I have not started this treatment yet but reading indicates side effects similar to Verzenio et al. My oncologist said Truqap is not in the same family as Verzenio et al though. As a side note, I was also in a Kisqali trial during 2019-2020 before losing my eyesight to corneal damage caused by bacterial infections in each eye 6 months apart (I add this to warn users to be aware of any eye sensitivity and see your optometrist immediately). Here is a link to more information on Truqap https://www.astrazeneca.com/media-centre/press-releases/2023/truqap-approved-in-us-for-hr-plus-breast-cancer.html

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Hi @vicsmit
Just reading your post here. I'm so sorry about what happened to you with Kisqali! That's awful! I've been on Kisqali for 3+ years now. Do you happen to remember what dose you were on during the trial? What were the first issues you noticed with your eyes?

How is Truqap working for you? Are you finding the side effects tolerable?

Prayers for you for all of this. Zebra

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