1. < Breast Cancer

Something new in the treatment arsenal?

Posted by nlb122 @nlb122, Sep 23, 2023

AstraZeneca reported positive results from a Phase 3 trial for a breast- cancer treatment, sending its American depositary receipts higher.

Shares of AstraZeneca (ticker: AZN) were up 1.7% to $68.16 in morning trading.

The company said the trial showed that the treatment, datopotamab deruxtecan, showed a significant improvement relative to chemotherapy in terms of progression-free survival. Plans to submit the drug for regulatory approval globally are underway.

Progression-free survival “is defined as the time from random assignment in a clinical trial to disease progression or death from any cause,” according to the National Library of Medicine.

Interested in more discussions like this? Go to the Breast Cancer Support Group.

leeann66 | @leeann66 | Sep 28, 2023

Hello,

I was diagnosed stage 4 June 2020 with mets to my bones, started on Kisqali and Anastrozole July 13. After 19 months I started to get pain in my breast, similar to when I was diagnosed. I told my oncologist that I thought the cancer was growing again and a scan showed that it was. I switched to Afinitor and Exemastane but had a bad rash and trouble breathing so was taken off after 6 weeks. I was then on Xeloda for 6 months, I didn't have any indication from my body on how it was doing but scans at 3 months then at 6 months showed it wasn't working and the cancer had progressed.

I was without treatment for 7 weeks while my oncologist tried to get me into this trial, and I started in the Tropion 01 trial November 1. Adjusting to side effects was a bit of a journey but now with the right combination of medication for constipation and nausea (which only happened day 4 and 5 post chemo which is every 3 weeks) things are very manageable.

I have no hair anywhere and have fatigue, but I do all the things I need to do around the house, I go to dragon boat practice twice a week, golf once a week, dinners and drinks with my hubby and our friends and weekends are busy with our 4 kids and 2 grandkids. I am not missing out on anything. Yes, I have to rest more and there have been challenges with chemo mouth sores but again, getting the right combination of medications for all side effects is giving me a very good quality of life!!!

Let me know if you have any other questions, happy to share.

REPLY
3 replies
Zebra | @californiazebra | Sep 28, 2023
In reply to @leeann66 "Hello, I was diagnosed stage 4 June 2020 with mets to my bones, started on Kisqali..." + (show)
@leeann66

Hello,

I was diagnosed stage 4 June 2020 with mets to my bones, started on Kisqali and Anastrozole July 13. After 19 months I started to get pain in my breast, similar to when I was diagnosed. I told my oncologist that I thought the cancer was growing again and a scan showed that it was. I switched to Afinitor and Exemastane but had a bad rash and trouble breathing so was taken off after 6 weeks. I was then on Xeloda for 6 months, I didn't have any indication from my body on how it was doing but scans at 3 months then at 6 months showed it wasn't working and the cancer had progressed.

I was without treatment for 7 weeks while my oncologist tried to get me into this trial, and I started in the Tropion 01 trial November 1. Adjusting to side effects was a bit of a journey but now with the right combination of medication for constipation and nausea (which only happened day 4 and 5 post chemo which is every 3 weeks) things are very manageable.

I have no hair anywhere and have fatigue, but I do all the things I need to do around the house, I go to dragon boat practice twice a week, golf once a week, dinners and drinks with my hubby and our friends and weekends are busy with our 4 kids and 2 grandkids. I am not missing out on anything. Yes, I have to rest more and there have been challenges with chemo mouth sores but again, getting the right combination of medications for all side effects is giving me a very good quality of life!!!

Let me know if you have any other questions, happy to share.

Jump to this post

Thank you @leeann66 for that great summary of your treatment experience. It’s all helpful to know. You’ve been through a lot but I’m glad you feel like you have good quality of life right now and can still participate in the activities you love with the proper rest in between. You’re a trooper with a great attitude. This new treatment sounds very promising for everyone. Prayers for your continued improvement. Zebra

REPLY
1 reply
leeann66 | @leeann66 | Sep 28, 2023
In reply to @californiazebra "Thank you @leeann66 for that great summary of your treatment experience. It’s all helpful to know...." + (show)
@californiazebra

Thank you @leeann66 for that great summary of your treatment experience. It’s all helpful to know. You’ve been through a lot but I’m glad you feel like you have good quality of life right now and can still participate in the activities you love with the proper rest in between. You’re a trooper with a great attitude. This new treatment sounds very promising for everyone. Prayers for your continued improvement. Zebra

Jump to this post

Here is the link to the latest results on this trial.

https://www.astrazeneca.com/media-centre/press-releases/2023/dato-dxd-improved-pfs-in-breast-cancer.html
REPLY
1 reply
nlb122 | @nlb122 | Sep 28, 2023

So much good information from patient experience to clinical trial results. It does sound very promising. Thanks to everyone for sharing your story and expertise.

REPLY
anjalima | @anjalima | Sep 29, 2023
In reply to @leeann66 "Hello, I was diagnosed stage 4 June 2020 with mets to my bones, started on Kisqali..." + (show)
@leeann66

Hello,

I was diagnosed stage 4 June 2020 with mets to my bones, started on Kisqali and Anastrozole July 13. After 19 months I started to get pain in my breast, similar to when I was diagnosed. I told my oncologist that I thought the cancer was growing again and a scan showed that it was. I switched to Afinitor and Exemastane but had a bad rash and trouble breathing so was taken off after 6 weeks. I was then on Xeloda for 6 months, I didn't have any indication from my body on how it was doing but scans at 3 months then at 6 months showed it wasn't working and the cancer had progressed.

I was without treatment for 7 weeks while my oncologist tried to get me into this trial, and I started in the Tropion 01 trial November 1. Adjusting to side effects was a bit of a journey but now with the right combination of medication for constipation and nausea (which only happened day 4 and 5 post chemo which is every 3 weeks) things are very manageable.

I have no hair anywhere and have fatigue, but I do all the things I need to do around the house, I go to dragon boat practice twice a week, golf once a week, dinners and drinks with my hubby and our friends and weekends are busy with our 4 kids and 2 grandkids. I am not missing out on anything. Yes, I have to rest more and there have been challenges with chemo mouth sores but again, getting the right combination of medications for all side effects is giving me a very good quality of life!!!

Let me know if you have any other questions, happy to share.

Jump to this post

Your progress and your attitude are inspirational; a true gentle warrior LIVING YOUR LIFE🌸

REPLY
joiful | @joiful | Sep 30, 2023
In reply to @leeann66 "Hello, I was diagnosed stage 4 June 2020 with mets to my bones, started on Kisqali..." + (show)
@leeann66

Hello,

I was diagnosed stage 4 June 2020 with mets to my bones, started on Kisqali and Anastrozole July 13. After 19 months I started to get pain in my breast, similar to when I was diagnosed. I told my oncologist that I thought the cancer was growing again and a scan showed that it was. I switched to Afinitor and Exemastane but had a bad rash and trouble breathing so was taken off after 6 weeks. I was then on Xeloda for 6 months, I didn't have any indication from my body on how it was doing but scans at 3 months then at 6 months showed it wasn't working and the cancer had progressed.

I was without treatment for 7 weeks while my oncologist tried to get me into this trial, and I started in the Tropion 01 trial November 1. Adjusting to side effects was a bit of a journey but now with the right combination of medication for constipation and nausea (which only happened day 4 and 5 post chemo which is every 3 weeks) things are very manageable.

I have no hair anywhere and have fatigue, but I do all the things I need to do around the house, I go to dragon boat practice twice a week, golf once a week, dinners and drinks with my hubby and our friends and weekends are busy with our 4 kids and 2 grandkids. I am not missing out on anything. Yes, I have to rest more and there have been challenges with chemo mouth sores but again, getting the right combination of medications for all side effects is giving me a very good quality of life!!!

Let me know if you have any other questions, happy to share.

Jump to this post

Thank you @leeann66 for your share and inspiration. You’re a brave woman and I think it’s wonderful that you have a good quality of life and such a positive attitude.

REPLY
Zebra | @californiazebra | Nov 14, 2023
In reply to @leeann66 "Hello, I am in Montreal and I am in Phase 3 of the trial you are..." + (show)
@leeann66

Hello, I am in Montreal and I am in Phase 3 of the trial you are talking about.

The trial is called Tropion 01 for HR+ HER2 - (or low). I started Nov 1, 2022.

To qualify you have to be stage 4 and have already tried a few other lines of treatment. I had been on Kisqali, Afinitor, and Xeloda prior to this trial.

When I started the trial, I had a tumour in my left breast, several lymph nodes under my left arm were impacted, and I had Mets in my hips, my lower spine, my sixth rib, one of my vertebrae‘s and my sternum. Currently the only cancer that can be seen on The CT scan is in three of my lymph nodes, which is significantly smaller.

I imagine we will be hearing more talk about this at the San Antonio symposiu

Jump to this post

Hi @leeann66
Have you had anymore CT scans since this September update? Cancer in the lymph nodes gone? Still feeling okay? Thanks for any update.

REPLY
1 reply
leeann66 | @leeann66 | Nov 14, 2023
In reply to @californiazebra "Hi @leeann66 Have you had anymore CT scans since this September update? Cancer in the lymph..." + (show)
@californiazebra

Hi @leeann66
Have you had anymore CT scans since this September update? Cancer in the lymph nodes gone? Still feeling okay? Thanks for any update.

Jump to this post

Hello! I have one November 27 so will know about a week after that. I am feeling well! Had one cycle
That I felt like I was getting a flu the whole
Time but was just very run down I think as all good now and back to normal. A few exhausted achy days post chemo but otherwise good and living my life! Reach out and remind me after first week of December for scan news! Hope you are well!

REPLY
2 replies
Zebra | @californiazebra | Nov 16, 2023
In reply to @leeann66 "Hello! I have one November 27 so will know about a week after that. I am..." + (show)
@leeann66

Hello! I have one November 27 so will know about a week after that. I am feeling well! Had one cycle
That I felt like I was getting a flu the whole
Time but was just very run down I think as all good now and back to normal. A few exhausted achy days post chemo but otherwise good and living my life! Reach out and remind me after first week of December for scan news! Hope you are well!

Jump to this post

@leeann66 good to hear you're doing well! Praying you have great scan results!

REPLY
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