Smoking cannabis post transplant

Posted by glopers @glopers, Dec 10, 2021

Does anyone know how immunosuppressed a person has to be before they can be declared safe to smoke?

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Hi @glopers and welcome to Mayo Clinic Connect.
I'd like to invite @athenalee to the conversation as she did some research on CBD after her liver transplant.
What type of transplant did you have?


Thank you Amanda and hello @glopers, welcome to Connect.

If you are currently taking immunosuppressants you should definitely check with your doctors about consuming cannabis. Both THC and CBD interfere with the metabolism of many medications. Most drugs, including cannabis, are metabolized through the cytochrome P4503A (CYP3A4) pathway. Cannabis can cause your medications to increase or be lowered in your system, potentially doing great harm to your body. There are nearly 400 known drug interactions with cannabis.

I know as a transplant recipient, Calcineurin Inhibitors, including Tacrolimus and Cyclosporine, will be increased in my blood levels if I consume cannabis. This can lead to toxicity in my body and rejection of my new organ.

You can check to see if the medications you take are listed as interacting with cannabis on But, even if they are not, I’d still recommend you consult your doctors.
If you’re interested, I’ve also attached an article on the drug interaction process. I suffer from constant pain and other neuropathy symptoms which I know could be relieved by cannabis. But, it’s not worth risking my life.

Shared files

Cannabis canlivj (Cannabis-canlivj.2018-0023.pdf)

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