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Sinemet (Carbidopa-Levodopa) and nausea

Posted by kathy49 @kathy49, Apr 7 10:01am

Been on c/l for some weeks now...still at lower. dose with 1 25-100 tab am and 1/2 mid day and 1/2 dinner time. I have been carefully timing them 30 minutes prior to meals for full absorption as per the instructions. Now with the full tablet in morning nausea is an issue. Never experienced that ever in my life and hate the feeling. I am considering just taking it with meals and risk less absorption. Anyone done this with success? As for the hand tremor it is better not entirely gone but rarely think about it. Any advice welcome.

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NasbyE | @nasbyevan | Apr 23 8:25am
In reply to @radioactivems "@lisalucier I've been very fortunate. I haven't really had any side effects from the C/L. I..." + (show)
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@lisalucier I've been very fortunate. I haven't really had any side effects from the C/L. I have joined a fitness center and am participating in my first Rock Steady Boxing class today. I'm going to get into the best physical shape I can. I told my wife this disease may eventually take me down. However, I'm going down fighting.

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@radioactivems @lisalucier @kathy49
I have been taking carbidopa-levodopa since 2024 and I haven't noticed any side-effects. My neurologist recommend not to eat two hours before taking the medication and wait one hour after taking the medication. If I did need to eat he recommended crackers or something with very low protein. He also recommended staying away from nuts because of the high protein levels.

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139108 | @139108 | Apr 23 7:49pm

I struggled with nausea for a long time. Finally landed on a “plain” 25 mg Carbidopa And
A meal, especially in the morning. I take the Carbidopa with each does, 3 times a day.

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hld1975 | @hld1975 | Apr 25 10:58pm
In reply to @139108 "I struggled with nausea for a long time. Finally landed on a “plain” 25 mg Carbidopa..." + (show)
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I struggled with nausea for a long time. Finally landed on a “plain” 25 mg Carbidopa And
A meal, especially in the morning. I take the Carbidopa with each does, 3 times a day.

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I started Sinemet 7 months ago, 1/2 pill for a month, then to 1 pill twice daily. I had nausea sometimes, but not all the time. Did not want to take extra Carbidopa, so I tried taking Sinemet when finishing my meal, standing up, and moving around for a while. If I feel nauseated, then I eat a pickle or a pickled palm heart. Usually, my nausea goes away. I don't know if what I did worked or if my GI system is gradually getting used to Sinemet.

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trseaman0 | @trseaman0 | Apr 26 1:51pm
In reply to @hld1975 "I started Sinemet 7 months ago, 1/2 pill for a month, then to 1 pill twice..." + (show)
Profile picture for hld1975 @hld1975

I started Sinemet 7 months ago, 1/2 pill for a month, then to 1 pill twice daily. I had nausea sometimes, but not all the time. Did not want to take extra Carbidopa, so I tried taking Sinemet when finishing my meal, standing up, and moving around for a while. If I feel nauseated, then I eat a pickle or a pickled palm heart. Usually, my nausea goes away. I don't know if what I did worked or if my GI system is gradually getting used to Sinemet.

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@hld1975

I've been on Sinemet now since I was 32 years old and now I'm 65 years old. I remember what it was like when I first started on Sinemet and I had the same problems your going through. All I can say eventually it does get better and more tolerable. It just takes time.

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hld1975 | @hld1975 | Apr 26 4:05pm
In reply to @trseaman0 "@hld1975 I've been on Sinemet now since I was 32 years old and now I'm 65..." + (show)
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@hld1975

I've been on Sinemet now since I was 32 years old and now I'm 65 years old. I remember what it was like when I first started on Sinemet and I had the same problems your going through. All I can say eventually it does get better and more tolerable. It just takes time.

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@trseaman0
How amazing! It's good to know that after 33 years, Sinemet still works!

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NasbyE | @nasbyevan | Apr 26 6:27pm
In reply to @trseaman0 "@hld1975 I've been on Sinemet now since I was 32 years old and now I'm 65..." + (show)
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@hld1975

I've been on Sinemet now since I was 32 years old and now I'm 65 years old. I remember what it was like when I first started on Sinemet and I had the same problems your going through. All I can say eventually it does get better and more tolerable. It just takes time.

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@trseaman0
May I ask why you were prescribed carbidopa-levodopa (sinemet) at 32 years old? I'm 31 years old I have been on carbidopa-levodopa since 2024. I have learned since being on it that its not commonly prescribed to young people and very rare for off-label usage, like in my case. I have had a permanent right calf cramp since 2021, with atrophy starting 2023 and all medical tests are negative/normal and in 2024 a neurologist from the Mayo Clinic prescribed me carbidopa-levodopa and it has helped with the stiffness of the calf. I take 4 pills 3 times daily.

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