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Anyone have experience with CAR-T therapy for multiple myeloma?
I was diagnosed with MM in July 2022 at age 53. Did induction on RVD followed by autologous transplant in Dec 2022. Never achieved MRD negative, and have been on Darzalex trial for maintenance. Disease has returned over the past 3-4 months and now contemplating bridging therapy in prep for CAR-T. Still working in fairly high stress occupation and trying to figure out what CAR-T looks like while trying to work. Any insights or counsel from the community? With gratitude…..
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HugInterested in more discussions like this? Go to the Bone Marrow Transplant (BMT) & CAR-T Cell Therapy Support Group.
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Hi @claydavis, I moved you question to the Bone Marrow Transplant (BMT) & CAR-T Cell Therapy support group here: https://connect.mayoclinic.org/group/car-t-cell-therapy/
I'm tagging @4health4bonnie @mohusker @jrbris23 @cjj2 @pgollinger @merrle @myelomawarrior who have talked about CAR-T therapy for multiple myeloma and may be able to help answer your questions.
Also see these related discussions:
- Stem cell transplant vs CAR-T: What can I expect with CAR-T?https://connect.mayoclinic.org/discussion/stem-cell-transplant-vs-car-t/
- CAR-T after MM relapse 13 months post-ASCT https://connect.mayoclinic.org/discussion/car-t-after-mm-relapse-13-months-post-asct/
- Starting pre-tests for CAR-T infusion for multiple myeloma https://connect.mayoclinic.org/discussion/car-t-infusion-for-multiple-myeloma/
@claydavis, working during treatment is hard to predict and may depend on what type of work you do. Working a stressful job is hard at the best of times. Are you able to take time off during treatment?
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3 ReactionsAnyone tried CAR-T
with Plasma Cell Lukemia Lukemia ?
No, but I have it and am on my fifth of eight three week cycles of
Of chemo , after three weeks of induction therapy at Fred
Hutch in Seattle .
Plasma Cell Leukemia was diagnosed on April 28 2025.
After these cycles , we’ll evaluate
the next move. . CAR-T ?
Don’t know ?
Please keep in touch.
We are Rare!
Happy New Year
This is a continuation of above. Answering
Myself.
Just looking for any one else
With Plasm Cell Lukemia
as with stem cell transplant car t requires hitting your immune system hard prior to, and then almost quarnteening yourself for a month or more after. you will probably not be working your job for at least a month.
my 54 yo daughter went through that but her t cells / marrow were so exhausted by 1.5 yrs of various trials, that it didn't really take. she was triple risk , meaning three markers, so it was a long shot. i hope you don't have similar risk markers. those without high risk markers seem to do much better with car t. good luck.
Hi claydavis. We have the same last name and same disease! Was diagnosed with multiple myeloma in 2018 at age 58.
I worked in healthcare during all my treatments, which wasn’t wise because of the lack of immune system. But I HAD to work! I had the Car T transplant in 2024. It put the cancer into remission! I wish I could have done the Car T BEFORE the Bone Marrow Transplant, but you have to have 4 lines of therapy before the Car T.
You have to stay home from work and germs and not drive afterwards, for like three months,
as your system recovers.
I would recommend the Car T Cell transplant.