Repatha reaction?

I've just stopped taking Repatha without my doctor's approval after taking it for a year . She thinks I'm jumping to conclusions but I've been down this road b4. When I was given statins and developed incredibly severe leg pains I was told it was unrelated until the pain was so bad I couldn't work anymore. I stopped the meds & the pain went away. So then I went through all the statins & still experienced either extreme muscle or joint pain. I have familial hyperglycemia which killed my dad at 61. I thought Repatha would be great. The result was much lower bad lipids but my triglycerides and blood sugar went up. As time went on the joint pain which started as a twinge became very severe. I can't stand more than a minute now. I feel like I'm 110 yrs old trying to get up out of a chair. The intestinal issues started small but with time got worse and worse. So I was prescribed more meds and PT to try to counteract all these side effects. Now that I've stopped Repatha the side effects are slowly improving. I'm glad this drug works for some people but it's really terrible to suffer all these side effects every day. I know I am running the risk of a cardiac issue but then I'm trading that for less pain, stiffness and terrible intestinal issues every single day. If you have symptoms, don't let your doctor tell you you're imagining it.

I have only had one dose and most of the time I had nausea and one time vomiting. No diarrhea but I have chronic constipation, so that might be helpful for me. I already had diagnosed heart PVCs and flutters since diagnosed with Hashimoto's thyroiditis. I told nurse that if the nausea and not wanting to eat continues, I won't be continuing. I can't take statins which would help tremendously because of severe myalgia. Diet and exercise don't help with lipids and my advanced lipids panel was really bad. Plus, I had high CR-P inflammation marker. I am more worried about the blood sugar and maybe that is why I am nauseous and feeling light sometimes. I wonder if the symptoms will go away or ease up.

I took my first dose 6 days ago. I threw away the second dose as the side effects so far are horrible. I have genetic familial hypercholesterolemia for 40 years now. I am unable to take statins due to side effects. I have one stent and last screening shows minimal blockage. Rapatha is not the way for me. For the last 5 days I can barely walk due to the joint pains in my legs, ankles, and feet. My back hurts like no other and I have had two back surgeries. The injection has exasperated my asthma. I am extremely light headed and lastly this has increased my blood sugar levels like no other. I will be calling my PCP as my cardiologist is not the easiest person to get a hold of and I refuse to pay the money for an ER visit. I am very happy to have found this blog, makes me not second guess my symptons and know that I am not alone. Can anyone tell me when the symptons will calm down and go away?

@funnylady Agree. I am having gastric issues with Repatha and do not want high blood sugar so they can give me another medication. I will stop before taking more "band aids" for symptoms that don't have a real cure. I had severe myalgia with statins so cannot take those. I still have muscle and now tendon pain but even before Repatha. I am waiting to see if it makes them worse. Gluteal Tendonopathy is what I am working on for past 10 years and now I could be making it worse! I am taking my second injection today, so will see how the next 2 weeks go. If the same or worse, I will be stopping.

@cawiegand I think the symptoms calming down will be individual. It's been 6 weeks for me and I am feeling the difference. From what I have read, it builds up in your body slowly, which is why I was missing the cause. Some people say they have relief as soon as they stop, but for me, I felt the joint relief start after 3 weeks or so. I am moving SO much better & can get up and down out of a chair or off the floor much, much easier. The gastric issues are slowly getting better. It's going to take months to get it all out of my system. I hope your relief is quick.

@funnylady So, you continued on the medication and the symptoms subsided gradually over months? I was wondering if that would be the case. Repatha does make me not want to eat. My issue with that is I only want to eat things soft and bland and that isn't good for diet. I hope that changes.