Rare serious side effect of Eliquis: Muscle weakness

Posted by cmauncc1 @cmauncc1, Dec 27, 2021

In late July 2017 I was admitted for very high heart rate and Afib. Had been, and still am, on minimal meds. Hospitalist put me on Eliquis, 5mg 2X/day.

Within a month my leg muscles were weakening to the point where I could no longer play Pickleball or walk golf. Within a few weeks my Cardiologist did an ablation and inserted a loop recorder. For the next 2-1/2 years the loop recorder saw MINIMAL Afib, under 0.5%; the ablation did its job.

By November 2017 I needed a walker. By December 2017 I needed to be wheelchair pushed through an Ice Sculpture display as there was no way I could walk the 25-30 minutes of the exhibit.

When I finally got to see a Neurologist at Shands (Univ of FL, Gainesville) in July 2018, he ran an extensive battery of blood work tests but could find nothing to explain the muscle weakness.

Has anyone else encountered similar muscle effects following being prescribed Eliquis?

Interested in more discussions like this? Go to the Heart Rhythm Conditions Support Group.

@marilyn222

I was prescribed Eliquis after a cardiac catheterization procedure to look at my R heart valve. It caused AFIb permanently and I was given a clean bill of health post cardiac catheter surgery only to discover that I was actually injured. I don’t blame the surgeon. I blame the Cardiologist. Turns out he’s a narcissist and he made the decision that was wrong. It not only cost me getting a new hip, it has now cost me the ability to walk! Eliquis struck again! It’s a horrible drug. How was I supposed to know? I just turned 62 and I am thinking (and very terrified), that I may have to go to live in Assisted Living. I’m scared! I am meeting with an Inventional Cardiologist to discuss whether or not I am a candidate for the Watchman I know and you know what if I’m taking a stroke that’s not normal caused by Eliquis. AND nobody believes that Eliquis caused my extreme pain. I have no life anymore. I simply needed a new hip. And now, it’s the least of my worries! I can barely walk.

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I accidentally turned on my microphone…this message got messed up. But the bottom line is that I developed extreme spine pain with intense pain radiating down both legs. L leg pain is worse. I have had a Doppler to rule out DVT blood clots. It’s getting worse by the day.

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I started this one week ago and my muscles started in my legs, getting weaker and weaker now moving to my arms and hands. I thought it was just me but now when I read this, it’s got to be a side effect.

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@kander007

I started this one week ago and my muscles started in my legs, getting weaker and weaker now moving to my arms and hands. I thought it was just me but now when I read this, it’s got to be a side effect.

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@kander007

Contact your cardiologist ASAP about your symptoms.

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@joaf37

I started a response to this but was cut off .. you may see a partial response. I have been taking Eliquis for about 2 years. I am traveling or I would look at the enclosed sheet that comes with the RX. From the beginning I either was told or read in that document that a side effect of Eliquis can be muscle weakness. I clearly recall that as a concern I had . I am on the same dose as you described. The effect I do have is with the AM dose. That can vary at times. When it affects me most often I feel very "loop-y") with the AM dose for about an hour. Never with the night dose. However per the above comment about muscle weakness, my neighbor had it prescribed and had severe muscle weakness from the start with the Rx discontinued as a result. I just looked on line (Google) on your behalf. I input "Eliquis side effects". The few items noted don't report muscle weakness. However I did this a second time and entered: "Eliquis muscle weakness" it was the third in the list that popped up. Hope this helps a bit.

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That’s exactly what I did too. Still, the Cardiologist and his PA say it doesn’t happen. Meanwhile, I have no quality of life. I did read that another woman in this thread has said she is now in a wheelchair. I live alone. I’m super frightened. I just turned 62. I am switching Cardiology practices. My PCP recommended a new Cardiologist and I am meeting with an Interventional Cardiologist to discuss the Watchman and determine if whether or not I am a candidate for it. At this time, I am in a highly dangerous situation because I am only taking aspirin and I took too many Liquid Advil trying to work after a botched hip revision surgery (obviously my first hip replacement surgery was botched too) but the second one was REALLY bad. In Henderson, NV. I should have listened to Mother and returned home to New York for that surgery. I started bleeding out, took a bunch of anti diarrheal meds and walked into the ER on my own while my Mom parked the car. They took me immediately. I have been fairly healthy other than my hip pain but now this. It’s just very depressing.

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@marilyn222

That’s exactly what I did too. Still, the Cardiologist and his PA say it doesn’t happen. Meanwhile, I have no quality of life. I did read that another woman in this thread has said she is now in a wheelchair. I live alone. I’m super frightened. I just turned 62. I am switching Cardiology practices. My PCP recommended a new Cardiologist and I am meeting with an Interventional Cardiologist to discuss the Watchman and determine if whether or not I am a candidate for it. At this time, I am in a highly dangerous situation because I am only taking aspirin and I took too many Liquid Advil trying to work after a botched hip revision surgery (obviously my first hip replacement surgery was botched too) but the second one was REALLY bad. In Henderson, NV. I should have listened to Mother and returned home to New York for that surgery. I started bleeding out, took a bunch of anti diarrheal meds and walked into the ER on my own while my Mom parked the car. They took me immediately. I have been fairly healthy other than my hip pain but now this. It’s just very depressing.

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@marilyn222

You need all options from your new cardiologist and perhaps a referral to a cardiac surgeon to get their insights if you are thinking of any surgery.

If you have the Watchman procedure, most take Eliquis for 2 /3 months before going off it as a protective measure.

Does Watchman address arrhythmias? I just think that it gets you off Eliquis.

Are there any options to Eliquis?

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It prevents blood from pooling in the top L portion of the heart. I have done a lot of research on this and that part of the heart doesn’t serve any purpose other than to pool blood, form a clot and cause a stroke. I would be willing to take Warfarin post surgery. I can’t take Eliquis or Zarelto. They are working on different types of blood thinners because there’s no way to treat a bleed very well. Dangerous drugs.

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@timely

@marilyn222

You need all options from your new cardiologist and perhaps a referral to a cardiac surgeon to get their insights if you are thinking of any surgery.

If you have the Watchman procedure, most take Eliquis for 2 /3 months before going off it as a protective measure.

Does Watchman address arrhythmias? I just think that it gets you off Eliquis.

Are there any options to Eliquis?

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The Watchman is only to prevent a blood clot and stroke. I will have to take Warfarin during the recovery period because I just can’t tolerate Eliquis or Xarelto. So yes, it “just “ gets me off Eliquis and Xarelto. That may seem like a lot to go through but Eliquis is is very dangerous. They are working on a replacement for it. Hopefully, they will be honest about the clinical trials with the new medication. They weren’t with Eliquis and for those of us who can’t walk very well now after only taking it for two days, The Watchman is a true blessing. Right now, I’m in a very dangerous place. My heart rate has been very difficult to control and I am in AFib a LOT. I completely cut out my green tea. That alone leaves me feeling very tired. I am going to have to have that procedure to shock my heart back into normal sinus rhythm. Neither my PCP nor I can understand why it hasn’t been done yet. It’s why I’m switching Cardiologists and Practices. Apparently, the Cardiology practice that I am switching to was started by the Cardiologists who left the place I am currently going to. I have one final appointment with them this week and then I will contact them to get my records sent over to the new practice. My PCP said that even if I don’t get assigned to the doctor that I read about, I will very happy with any of the other Cardiologists. After what happened to me with my hip replacement surgeries in NV, I just can’t believe that I didn’t listen to my voice of reason and switch Cardiologists last year. He waited until I was days away from getting my new hip and then backed me into a corner and forced me to have cardiac catheterization surgery. I was given a clean bill of heart health but the orthopedic surgeon said that he was going to wait 8 weeks post surgery. Now, I have discovered that the unnecessary surgery in December has caused permanent AFIb and the medications he has been trying are making me very sick. The latest one is just to slow my heart rate down and it’s working better than the previous ones.

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@kander007

I started this one week ago and my muscles started in my legs, getting weaker and weaker now moving to my arms and hands. I thought it was just me but now when I read this, it’s got to be a side effect.

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I definitely believe it is. It’s been around 6 weeks since I took the Eliquis and I still can barely walk. I thought it would get better once I stopped taking it but it is not the least bit better. I hope you recover from taking it. I live alone. I’m really struggling.

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@marilyn222

The Watchman is only to prevent a blood clot and stroke. I will have to take Warfarin during the recovery period because I just can’t tolerate Eliquis or Xarelto. So yes, it “just “ gets me off Eliquis and Xarelto. That may seem like a lot to go through but Eliquis is is very dangerous. They are working on a replacement for it. Hopefully, they will be honest about the clinical trials with the new medication. They weren’t with Eliquis and for those of us who can’t walk very well now after only taking it for two days, The Watchman is a true blessing. Right now, I’m in a very dangerous place. My heart rate has been very difficult to control and I am in AFib a LOT. I completely cut out my green tea. That alone leaves me feeling very tired. I am going to have to have that procedure to shock my heart back into normal sinus rhythm. Neither my PCP nor I can understand why it hasn’t been done yet. It’s why I’m switching Cardiologists and Practices. Apparently, the Cardiology practice that I am switching to was started by the Cardiologists who left the place I am currently going to. I have one final appointment with them this week and then I will contact them to get my records sent over to the new practice. My PCP said that even if I don’t get assigned to the doctor that I read about, I will very happy with any of the other Cardiologists. After what happened to me with my hip replacement surgeries in NV, I just can’t believe that I didn’t listen to my voice of reason and switch Cardiologists last year. He waited until I was days away from getting my new hip and then backed me into a corner and forced me to have cardiac catheterization surgery. I was given a clean bill of heart health but the orthopedic surgeon said that he was going to wait 8 weeks post surgery. Now, I have discovered that the unnecessary surgery in December has caused permanent AFIb and the medications he has been trying are making me very sick. The latest one is just to slow my heart rate down and it’s working better than the previous ones.

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If you google green tea and Afib you will find many many papers claiming the positive effects of green tea with Afib
Below it just the first of many that popped up on my google page.

Low-dose green tea intake reduces incidence of atrial fibrillation in a Chinese populationhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356761/

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My wife has gone throuh something very similar to what you went through.

Last year 2023 my wife was prescibe to E;liquis . Within a few months my wife became weaker and weaker util she could not support her weght. We check her into the hostpital to see what was wrong. Wile she was in the hospital they gave her shots in her spine to find out what was wrong and the day she was released with no explination. No she is permantly stuk in a weelchair. She is 47 years old.

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