Radiation & ADT no real problem. Kidney stone lithotripsy terrible

Posted by johnny8924 @johnny8924, May 3 8:38am

Diagnosed in August 2024 Gleason 9. Started Orgovyx immediately. Then 28 sessions of IMRT, finished April 2025. Colonoscopy January 2026, unremarkable. Latest PSA March 2026 less than 0.04, testosterone less than 1. Taken off Orgovyx April 10, 2026, after 20 months. Now...standard shock wave lithotripsy April 23, 2026 to remove kidney stones. Massive complications, unbearable pain because not all the stones were blasted and they began piling on top of each other. Underwent laser lithotripsy on my birthdate April 28th, 2026. Pain is significantly diminished and apparently no stones remain. Should have done laser lithotripsy at the beginning? Yep. Have an appointment with radiation oncologist May 12th. He'll probably order a new PSA and testosterone test. Hoping for good results.

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Jeff Marchi | @jeffmarc | May 10 9:47pm

In reply to @sushilkbirla "@oldgreenpaint I wonder if the calcium loss from the bones (due to ADT) ends up as..." + (show)

@sushilkbirla
I would imagine that’s one reason they have you take calcium daily and get you on bone strengtheners. I started a bone strengthener one year after I started ADT.

johnny8924 | @johnny8924 | May 11 8:12am

My two lithotripsies in five days are not something that anyone would wish for. However, my latest blood reading results 3 days ago after going off Orgovyx one month ago were good. PSA less than 0.04. Same as in March 2026. Testosterone increased from less than 1 to 55.
One provider's notes while I was in the Emergency Room stated evidence of calcification on arteries, a new finding. Could 20 months of Orgovyx have contributed to this? I've been a daily exerciser for more than 50 years, still doing an hour or more of walking/ jogging, weight training, and three times a week racquetball or tennis. Thanks for your thoughts!

Jeff Marchi | @jeffmarc | May 11 11:05am

In reply to @johnny8924 "My two lithotripsies in five days are not something that anyone would wish for. However, my..." + (show)

@johnny8924
Orgovyx is generally not associated with the calcification issue you mention.. Did they tell you that you had atherosclerosis too? That can cause calcification of the arteries.

Age is a contributor. Are you sure you’ve had a test that would show that in the past?

You might want to review your previous tests and ask your doctor about it.

johnny8924 | @johnny8924 | May 11 1:07pm

In reply to @jeffmarc "@johnny8924 Orgovyx is generally not associated with the calcification issue you mention.. Did they tell you..." + (show)

@jeffmarc

Mr. Marchi,
Thank you for your insightful comments. Very much appreciated.
I never had any mention of atherosclerosis or vascular calcification in the past on any previous tests. I've been a daily exerciser since the early 1970's and try to follow a heart-healthy diet, but turned 74 on April 28, 2026.