Ok, I have successfully weaned off pristiq. I actually emailed this link to my MD because I had the same uncomfortable withdrawal symptoms each time I tried to wean off the medication. I tried the every other day and had to go back on because I was so dizzy and irritable! This is what he did and so far it has worked with little or no noticeable side effects. I was on 50 or 100 mg for 3 years. Most recently taking 100mg. He gave me 3 weeks of 50mg samples and prescribed 3 weeks of Prozac. To be taken concurrently. At the end of 3 weeks I stopped both cold turkey. He explained that Prozac seems to wean itself gradually over 5 weeks eliminating the withdrawal symptoms. I have been off both since December 28th. 6 days-so far no side effects. There is hope! I know it's scary!