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What are treatment options for platinum-resistant ovarian cancer?

Posted by peregrine007 @peregrine007, Apr 23, 2025

Hi, My wife was diagnosed with Stage IV High Grade Serous Ovarian Cancer in May 2024. After debulking and 7 chemotherapy sessions she had her cancer in remission in Jan 2025. First follow-up tests, CT Scan and bloodwork, CA-125 at 70 in April 2025 indicates the cancer has reoccurred. We see the GYN Oncologist tomorrow. Has anyone had any experience with platinum resistant cancer recently had new therapy drugs or clinic trails in SW Michigan to fight the reoccurrence? I’m trying to find best treatment options for my wife. Thank you.

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leftybarb | @leftybarb | Oct 26, 2025
In reply to @jenelleseaman "I have recurrent OC. I was able to have taxol and carboplatin several times before the..." + (show)
Profile picture for jenelleseaman @jenelleseaman

I have recurrent OC. I was able to have taxol and carboplatin several times before the cancer became platinum resistant.
Since then I have had Caelyx, which is PEGylated liposomal doxorubicin. It has been effective so far. I have had it for the third time since August last year.
I was first diagnosed in 2010. I have had more than my fair share of chemotherapy! Caelyx may be marketed under a different name where you live. I’m from Sydney, Australia.

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@jenelleseaman oh wow I never knew cancer was like this!! One chemo then another and I just started last year was finished I thought in December coz it was my last chemotherapy after my debulking surgery was over I had 3,left so i thought I was finished with chemo but they don’t tell you this stuff but I now wonder why? ?!is it to not get our hopes down so we continue to fight it or what ? I don’t believe it’s fair to believe the whole time tour going to ring that bell and it’s over with! Because it’s not it’s still
A battle and for how long ? I don’t want to suffer either with chemo the rest of my life . So does anyone ever beat it ?? Idk 🤷‍♀️ it’s sad to hear this is on going for you and I pray God keeps you going stronger every single day . Wondering how that long 2010
to 2025 ? That’s a long time and do you still take medicine or chemo to stop it from returning? I took Zejula and it still returned . Thanks for in info God bless you

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jenelleseaman | @jenelleseaman | Oct 26, 2025
In reply to @leftybarb "@jenelleseaman oh wow I never knew cancer was like this!! One chemo then another and I..." + (show)
Profile picture for leftybarb @leftybarb

@jenelleseaman oh wow I never knew cancer was like this!! One chemo then another and I just started last year was finished I thought in December coz it was my last chemotherapy after my debulking surgery was over I had 3,left so i thought I was finished with chemo but they don’t tell you this stuff but I now wonder why? ?!is it to not get our hopes down so we continue to fight it or what ? I don’t believe it’s fair to believe the whole time tour going to ring that bell and it’s over with! Because it’s not it’s still
A battle and for how long ? I don’t want to suffer either with chemo the rest of my life . So does anyone ever beat it ?? Idk 🤷‍♀️ it’s sad to hear this is on going for you and I pray God keeps you going stronger every single day . Wondering how that long 2010
to 2025 ? That’s a long time and do you still take medicine or chemo to stop it from returning? I took Zejula and it still returned . Thanks for in info God bless you

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@leftybarb I had another PET CT scan in September that showed it has returned, maybe even in the chest cavity which is unusual. I also have sarcoidosis ... I had biopsies done of the lymph nodes in my chest last Friday, where the doctor went through the esophagus to get to them! My oncologist wants me to have another scan in November, and then I'll start the next round of chemotherapy after that ... probably on 12th December. This time it is gemcitabine and carboplatin. This is the ninth time I will be going through chemo. My oncologist calls me his "Champion"! I have also been asked to recount my journey at an Oncology Conference on the 21st November as well! I have alot to say!! I have gone through more than just the chemo as well. I've had a Whipple's procedure too, which was very drastic!
I don't look unwell. I love shocking people with my history. I also have a very large support network that has allowed me to keep teaching throughout my treatment, when I have been able. I am very appreciative of every day that I get!

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