platinum-resistant ovarian cancer, treatment options

I have recurrent OC. I was able to have taxol and carboplatin several times before the cancer became platinum resistant.
Since then I have had Caelyx, which is PEGylated liposomal doxorubicin. It has been effective so far. I have had it for the third time since August last year.
I was first diagnosed in 2010. I have had more than my fair share of chemotherapy! Caelyx may be marketed under a different name where you live. I’m from Sydney, Australia.

@peregrine007 Welcome to our gynecological cancers support group on behalf of your wife. How kind of you to come here and ask about the experiences of others who have recurrent ovarian cancer.

I am tagging a few of our members @cipnsue @amywells @egins1208 @rdubins who I hope can share their experiences. Thank you to @jenelleseaman who jumped in quickly with her experience and suggestions.

You mentioned that you are in the SW region of Michigan. Is your wife being treated in Grand Rapids or Kalamazoo or is she being treated at the University of Michigan in Ann Arbor? I ask about the University of Michigan because they are one of the National Cancer Institutes-Designated Cancer Centers. There are two in Michigan and the other is at Wayne State.

-- https://www.cancer.gov/research/infrastructure/cancer-centers/find

Thank you for the reply that is very helpful and encouraging.

I had 6 chemo with carbon plaxin drug before the OC cancer got resistant (ca125 at 250). Then had major hysterectomy done. Cancer still there but my CA125 to 106. But then when they were testing to seeing this new drug would work (mervituxim) my ca125 shot up back up 1063. Started this infusion of the 'targeted' mervituxim in Nov 2024. My ca125 numbers dropped quickly . After 6 infusions, I am at 23 for my ca125.

We saw the oncologist yesterday in Kalamazoo, Michigan. 2nd line of treatment with include, Doxorubicin (ADRIAMYCIN) or PLD, and BEVACIZUMAB as maintenance drugs. The oncologist said my wife’s ovarian cancer treatment is now palliative. That was hard to hear. The oncologist is also looking at two different clinic trails in Grand Rapids, MI to see if she is a candidate. My wife is doing great with a strong faith. We will both stay positive with hope and pray.

We talked to the oncologist yesterday about Elahere and he said they will look at tumor tissue taken out during debulking surgery last September to see if my wife’s cancer is folate receptor-alpha positive ovarian cancer. Elahere seems like a great choice for platinum resistant cancer.

Great news. Hopefully it is a good match. It really works.

I found out by accident that I was on palliative chemotherapy in 2016. It was a shock, because I had always been under the impression that the doctors were trying to cure me. When I asked the oncologist about the word, he said that you can be on palliative chemotherapy for 20 years!
As I mentioned I have had OC since 2010. I have had the privilege of being able to plan my funeral for 15 years. The longer I live, the longer it will be. I once asked my oncologist what was the longest he’d ever treated anyone with recurrent OC? He told me 11 years. That was in 2022. I’m his record, and, he tells me, his Champion!
I’m prepared to die, but God keeps me alive for a purpose. I keep teaching, Jesus Christ keeps blessing. The past 5 years have been extremely difficult, with more surgeries, and chemotherapy every year. He keeps telling me “My grace is sufficient for you, in weakness is your strength”.
I have a PET CT scan in a week to find out what happens next.