Ovarian cancer - not responding to chemo

Posted by ktoth @ktoth, Jul 27 1:03pm

I have high grade serous carcinoma ovarian cancer. I have a 12cm tumor on my left ovary, the cancer has spread to two lymph nodes and also both of my lungs. I have had 4 rounds of paclitaxel and carboplatin. A CT scan was done post round 3 of chemo. The results show that the chemo is not working. The cancer lesions in my lungs have grown. The surgical oncologist said that I am currently not a candidate for surgery as the benefit doesn't outweigh the risk. We meet with the medical oncologist this Friday, July 31, 2026.

What other options are out there for me at this point since my cancer is platin resistant and that is typically the gold standard for treating ovarian cancer.

Does the Mayo clinic have more advanced options for someone like me in my current situation? I live in British Columbia Canada. Debating if I should seek treatment abroad where more advanced care would potentially be available for me.

I feel like I have just lost 3 precious months undergoing a chemotherapy that wasn’t working.

Interested in more discussions like this? Go to the Gynecologic Cancers Support Group.

When my cancer became platinum resistant, I was given another drug called Caelyx, which is a form of doxorubicin. You could ask whether that is an option.
I have also just been given topotecan, which the cancer has responded to.
I was diagnosed with high grade serous ovarian cancer, stage 3c in August 2010. Initially my cancer responded to taxol and carboplatin. I also had a radical hysterectomy, so surgery was an option. My cancer was in both ovaries, the peritoneal cavity and multiple lymph nodes.
Everyone is different. My oncologist has always been positive, and told me there’s always options.
All the best for Friday.

REPLY

Our hearts go out to you. Maybe you can do a couple of telemed consults before traveling?

REPLY

I have high grade serous cell endometrial cancer stage 3C. Had a radical hysterectomy, margins not cleared, no possibility of surgery. 6 rounds of Carb/Pac but only worked somewhat for a few months, then a new tumor in the vaginal cuff. Currently in a clinical trial testing Enhertu and it is working. NED. Enhertu works for HER 2+ and 3 and has been successful in treating breast cancer. https://www.mayoclinic.org/diseases-conditions/breast-cancer/expert-answers/breast-cancer/faq-20058066. The clinical trial is in Kelowna, but I don't know whether they are are still recruiting patients. You could ask your doctors if there is any possibility of getting on it or whether there are any other trials.

REPLY
Profile picture for jenelleseaman @jenelleseaman

When my cancer became platinum resistant, I was given another drug called Caelyx, which is a form of doxorubicin. You could ask whether that is an option.
I have also just been given topotecan, which the cancer has responded to.
I was diagnosed with high grade serous ovarian cancer, stage 3c in August 2010. Initially my cancer responded to taxol and carboplatin. I also had a radical hysterectomy, so surgery was an option. My cancer was in both ovaries, the peritoneal cavity and multiple lymph nodes.
Everyone is different. My oncologist has always been positive, and told me there’s always options.
All the best for Friday.

Jump to this post

@jenelleseaman thank you! Thank you for sharing this information with me. It gives me hope that there will be another treatment option for me.

REPLY
Profile picture for hlthcr2000 @hlthcr2000

Our hearts go out to you. Maybe you can do a couple of telemed consults before traveling?

Jump to this post

@hlthcr2000 I will see how my appointment goes on Friday. If I feel like I need a second opinion, perhaps a telehealth meeting is an option. I just want to know what the most advance options are available for me.

REPLY
Profile picture for cookercooker @cookercooker

I have high grade serous cell endometrial cancer stage 3C. Had a radical hysterectomy, margins not cleared, no possibility of surgery. 6 rounds of Carb/Pac but only worked somewhat for a few months, then a new tumor in the vaginal cuff. Currently in a clinical trial testing Enhertu and it is working. NED. Enhertu works for HER 2+ and 3 and has been successful in treating breast cancer. https://www.mayoclinic.org/diseases-conditions/breast-cancer/expert-answers/breast-cancer/faq-20058066. The clinical trial is in Kelowna, but I don't know whether they are are still recruiting patients. You could ask your doctors if there is any possibility of getting on it or whether there are any other trials.

Jump to this post

@cookercooker thank you for this! I will mention the clinical trial that you are doing at my appointment on Friday.

REPLY
Profile picture for ktoth @ktoth

@cookercooker thank you for this! I will mention the clinical trial that you are doing at my appointment on Friday.

Jump to this post

@ktoth Good luck and all the best.

REPLY

Getting a second, or even a third, opinion can be so helpful. And with telemedicine, you can get it from anywhere. The best cancer centers in the US are Mayo Clinic, MDAnderson, Dana Farber, Sloan Kettering, and Massachusetts General Hospital. They will want your medical records. Write down your questions in advance. Ask why they recommend what they are recommending. Ask about the pros and cons of each particular treatment. And then see if you can get the treatment you want in Canada. It will cost hundreds of thousands of dollars in the US if you don’t have American health insurance.
Good luck!

REPLY

Have your docs considered adding Keytruda into your infusions ? Some people have had success with that. Wishing you the best as you seek better treatment. Consider 2nd or 3rd opinions—there are options out there.

REPLY
Profile picture for lathomasmd @lathomasmd

Getting a second, or even a third, opinion can be so helpful. And with telemedicine, you can get it from anywhere. The best cancer centers in the US are Mayo Clinic, MDAnderson, Dana Farber, Sloan Kettering, and Massachusetts General Hospital. They will want your medical records. Write down your questions in advance. Ask why they recommend what they are recommending. Ask about the pros and cons of each particular treatment. And then see if you can get the treatment you want in Canada. It will cost hundreds of thousands of dollars in the US if you don’t have American health insurance.
Good luck!

Jump to this post

@lathomasmd thank you for this information. Hopefully we will be able to do a telehealth visit with the Mayo Clinic soon.

REPLY
Please sign in or register to post a reply.