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Ovarian cancer - not responding to chemo

Gynecologic Cancers | Last Active: 12 hours ago | Replies (31)

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I have high grade serous cell endometrial cancer stage 3C. Had a radical hysterectomy, margins not cleared, no possibility of surgery. 6 rounds of Carb/Pac but only worked somewhat for a few months, then a new tumor in the vaginal cuff. Currently in a clinical trial testing Enhertu and it is working. NED. Enhertu works for HER 2+ and 3 and has been successful in treating breast cancer. https://www.mayoclinic.org/diseases-conditions/breast-cancer/expert-answers/breast-cancer/faq-20058066. The clinical trial is in Kelowna, but I don't know whether they are are still recruiting patients. You could ask your doctors if there is any possibility of getting on it or whether there are any other trials.

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@cookercooker thank you for this! I will mention the clinical trial that you are doing at my appointment on Friday.

@cookercooker
I have also been on enhertu for serous cell endometrial cancer which recurred after 18 months of carb/pac.....it was approved by the FDA for endometrial cancer in August 2024. Not a trial drug anymore....I am being treated at MSK in NYC. I have been having infusions of enhertu since May of 2025 and my scans have all been NED since the first treatment...a very good targeted chemo drug for HER 2 + cancer....if you're a candidate for the drug it works ! Best of luck to you !