Orgovyx and Zytiga combined

Sorry to hear that Tom. So was this a first PSMA PET Scan you are referring to or a second one? If there was a previous one in the not to distant past, that would certainly indicate a pretty aggressive cancer. If instead you maybe had a less accurate MRI or Bone Scan, the metastases may have already been there but was simply missed, which is why the PSMA PET Scan is used. I say that only to keep you from going down the path that you're dealing with an extremely aggressive cancer. I haven't heard of anyone on the specific Orgovyx plus Zytiga combo, some of the newest line of approved medications. However, AR antagonists are commonly used with GnRH agonists to alleviate the effects of the testosterone surge that occurs with a GnRH agonist. And, I've read that extended AR antagonists may be used with GnRH agonists or antagonists to achieve combined androgen blockade (CAB). I expect they are looking for some of that synergy. I'm familiar with UFHPTI (Jax) so I know you're in good hands. I'm nearly the same age and am being treated at Mayo Jax myself. Best wishes!

Thanks very much for the reply! This was the first PSMA PET scan – I did have previous MRI Pelvis, CT Bone scans, which showed all clear. This latest PSMA PET scan was a shock. I'm sure the cancer was already there last summer when the standard Biopsi came back "all clear". When my PSA kept rising, they did a fusion biopsi which showed 3 Gleason 8 spots and 1 Gleason 7. My urologist didn't even mention Proton Therapy, only traditional Photon therapy together with HDR Brachy. He told a friend of mine some time ago that Proton therapy was hocus pocus. Lucky for me a friend told me about Proton – I contacted UFHPTI, read the books, and visited for a consult – and signed up. Thanks for your comments about the Antagonists and agonists. Makes sense. Good luck on your treatments at Mayo. Thanks, Tom

Stage 4 to my L2 where they radiated 1 inc outin 2020 and put me back on Zolodex after 4 years off Jan its in L1 so they added Xtandi and Xgeva PSA down from 9.8 to 1.7 in 2 months No affects except tired sometimes Have to avoid Pomegranate and grapefruit juice and those small oranges? as they offset Xtandi
Get on these I'm 78 now Radiation on prostate was Dec 2017 so lasting 6 years and now they say 5+ if it continues to work

Nice. Thank you !

Taking Orgovyx together with salvage radiation post RP. so not exactly answering your question.
however, my experience with 3 months of Orgovyx:
Side effects reasonably mild. Beware of falling; there is a feeling of wooziness or dizziness.
Some fatigue.
I try to walk 50 minutes or so every day or cut the lawn and sometimes I have to push through the desire to stop. also lift light weights (only 4 upper body lifts) 2 to 3 times a week.
both to try to maintain energy/stamina and muscle strength.
Hope this is helpful and best of luck to you.

Also I am 73 and the ADT seems to exacerbate all of my previously existing age related cognitive annoyances.

VERY helpful. Thank you. You know how it is – I read the published side effects and figure I’m gonna be totally whacked. Your reply is encouraging.