I'm 69. After a year of Firmagon injections, I was switched to Zytiga, and I have now been using Zytiga (Abiraterone) and Orgovyx for two years. Other than the occasional fatigue and the difficulty in telling what is what, since this has been the new normal for two years, I feel great. After the occasional hot flashes when I started, I now only get them rarely. When I do, it appears to be related to mistiming and missing my scheduled dose, taking it late (once by 8 hours and yes, I got a hot flash after the next dose 16 hours later). I take Zytiga at 3 pm and Orgovyx at 10 pm. After getting muscle cramps from taking Zytiga, I added Magnesium to my daily regime, and those have all but completely disappeared. (If I remember correctly, there's a warning in the literature about Magnesium depletion.) When I do feel a cramp start to come on (about every two weeks or more), I take an extra dose of Magnesium, and the symptoms disappear before I cramp up.

After three years of undetectable PSA, my doctor wants me to stop taking Abiraterone (Zytiga). Since I seem to tolerate them both very well, I'm pretty nervous about stopping. She tells me it will be healthier for me to quit, especially since I had a minor heart attack (no damage) about three years ago, around the time I was diagnosed with resistant prostate cancer. Stress? 😉 Plus, I'm also diabetic, and the prednisone has caused my skin to become more fragile. I would love to know more about the "maintenance" dosing she's suggesting, where I quit taking the Zytiga. It seems to me that Zytiga is the most beneficial drug against castration resistance. OTOH, I'm posting here today because I was searching for information.

I know Orgovyx has only been out since 01/2021. And I don't know how well or precisely what it does for me. I think taking it alone might expose me to an opportunity to a resistant strain. OTOH, she says it will allow me to normalize and that I will still have to have my PSA checked every three months, and as long as there's no change, there's no worries. If that happens, I also think there will always be the option to return to using Zytiga. But is that riskier than taking them both? I think the reason information about taking Zytiga and Orgovyx together is problematic *is because* Orgovyx hasn't been out that long yet. So, like you, I'm looking for information too.

Again, regarding how well it can be tolerated, I understand from the doctor that I am handling it well, and for the most part, and most days, I do great! (According to the doctor, the abnormalities in my blood work are "normal" for my treatment.) I have other issues that cause me more significant problems, but nothing that will kill me! lol. Ironically, pain doesn't usually kill, and it's unrelated to Prostate Cancer, but that's another story for another time or place! lol

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