New antidepressant: Has anyone tried Auvelity?

Posted by csmiller @csmiller, Oct 26, 2022

Anyone know the name of new antidepressant, approved by FDA, that's supposed to be available at end of this year?

Interested in more discussions like this? Go to the Depression & Anxiety Support Group.

Hi, I just joined the group. I haven't read enough of this discussion about Auvelity to know if many have had success with it. My psychiatrist is going to be prescribing it for me. I'm 62 years old and have struggled with depression and anxiety all my adult life. Within the last 10-15 years my depression has become resistant to treatment. I had ECT in 2006 and then again in 2019. I had some success but the effects on my memory was horrible. I took many different medications. In the last 3 years I have been battling periodic bouts with suicidal thoughts. Last year I had 36 TMS treatments that had virtually no impact on me. Towards the end of last year I started Spravato treatments. That's the nasal spray version of ketamine. Those treatments are still ongoing but, so far, have had minimal impact on my depression. I'm currently taking trintellix and wellbutrin. I also take klonopin for anxiety. I have not found out if my insurance will cover Auvelity. If it doesn't I may not be able to try it. I have been on disability for my depression for about 2.5 years. I have Medicaid and Medicare. Medicare started prescription coverage last year. It isn't part d. I think it's because I am on disability. Regardless, so far, everything ever prescribed has been covered 100%. I'm hoping Auvelity will be covered too. I am feeling pretty defeated right now. It's not like I have a bad life. I have a great family and awesome friends. Nothing seems to matter anymore. No energy, no interest in anything, feeling isolated from loved ones from my own doing. I really don't know what to do,especially if Auvelity doesn't help. I've had decades of psychotherapy. Please keep me posted on your experiences with Auvelity. Thank you.

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@bradd106

Hi, I just joined the group. I haven't read enough of this discussion about Auvelity to know if many have had success with it. My psychiatrist is going to be prescribing it for me. I'm 62 years old and have struggled with depression and anxiety all my adult life. Within the last 10-15 years my depression has become resistant to treatment. I had ECT in 2006 and then again in 2019. I had some success but the effects on my memory was horrible. I took many different medications. In the last 3 years I have been battling periodic bouts with suicidal thoughts. Last year I had 36 TMS treatments that had virtually no impact on me. Towards the end of last year I started Spravato treatments. That's the nasal spray version of ketamine. Those treatments are still ongoing but, so far, have had minimal impact on my depression. I'm currently taking trintellix and wellbutrin. I also take klonopin for anxiety. I have not found out if my insurance will cover Auvelity. If it doesn't I may not be able to try it. I have been on disability for my depression for about 2.5 years. I have Medicaid and Medicare. Medicare started prescription coverage last year. It isn't part d. I think it's because I am on disability. Regardless, so far, everything ever prescribed has been covered 100%. I'm hoping Auvelity will be covered too. I am feeling pretty defeated right now. It's not like I have a bad life. I have a great family and awesome friends. Nothing seems to matter anymore. No energy, no interest in anything, feeling isolated from loved ones from my own doing. I really don't know what to do,especially if Auvelity doesn't help. I've had decades of psychotherapy. Please keep me posted on your experiences with Auvelity. Thank you.

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Hi. Do you know about the Auvelity Savings Card? Go to the website. With that, I only pay $10 a month. Insurance wanted to charge me $85. It's a great deal. Good luck!

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I started taking Auvelity almost a week ago. It scares me to say but I think it is already starting to help. I am cautiously optimistic. I've had ECT, TMS and Spravato. I'm still having Spravato treatments. I'll keep you posted. I would be so shocked to actually experience some relief.

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@bradd106

I started taking Auvelity almost a week ago. It scares me to say but I think it is already starting to help. I am cautiously optimistic. I've had ECT, TMS and Spravato. I'm still having Spravato treatments. I'll keep you posted. I would be so shocked to actually experience some relief.

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Bradd,
Don't give up. Hang in there. I'm in the same boat. I've had everything that you had with the same results. I did not do ECT because of what I read, I don't trust the outcome.
I hope that you have some success and relief with Auvelity. All the best to you.

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@wrightrn

Hi. Do you know about the Auvelity Savings Card? Go to the website. With that, I only pay $10 a month. Insurance wanted to charge me $85. It's a great deal. Good luck!

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Typically if you are on Medicare, those savings cards aren't eligible. I've tried it for many drugs that are expensive, like Trintelix.

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@bradd106

Hi, I just joined the group. I haven't read enough of this discussion about Auvelity to know if many have had success with it. My psychiatrist is going to be prescribing it for me. I'm 62 years old and have struggled with depression and anxiety all my adult life. Within the last 10-15 years my depression has become resistant to treatment. I had ECT in 2006 and then again in 2019. I had some success but the effects on my memory was horrible. I took many different medications. In the last 3 years I have been battling periodic bouts with suicidal thoughts. Last year I had 36 TMS treatments that had virtually no impact on me. Towards the end of last year I started Spravato treatments. That's the nasal spray version of ketamine. Those treatments are still ongoing but, so far, have had minimal impact on my depression. I'm currently taking trintellix and wellbutrin. I also take klonopin for anxiety. I have not found out if my insurance will cover Auvelity. If it doesn't I may not be able to try it. I have been on disability for my depression for about 2.5 years. I have Medicaid and Medicare. Medicare started prescription coverage last year. It isn't part d. I think it's because I am on disability. Regardless, so far, everything ever prescribed has been covered 100%. I'm hoping Auvelity will be covered too. I am feeling pretty defeated right now. It's not like I have a bad life. I have a great family and awesome friends. Nothing seems to matter anymore. No energy, no interest in anything, feeling isolated from loved ones from my own doing. I really don't know what to do,especially if Auvelity doesn't help. I've had decades of psychotherapy. Please keep me posted on your experiences with Auvelity. Thank you.

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My story is almost identical to yours. I have medication resistant major depression. I have tried both TMS and soravato. TMS helped but only for a short time. Soravato helped only if I had treatment at least once a week, which I could not afford. I started on Auvelity 6 weeks ago and, to my amazement, have felt some relief. But, alas, I have discovered that after the first 3 or 4 months my co-pay will jump from $35 a month to about $250 a month, which I cannot afford. I am on Medicare. For those with private health insurance discount cards are available but not for those on Medicare or Medicaid. I think it is unconscionable that our government does nothing to make necessary medications available to seniors on Medicare. If you can afford Auvelity you should definitely try it. The medication costs over $1000 for one month's supply, so you may want to make sure that you can still afford it if you go into insurance gap after just 3 or 4 months.

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@bradd106

Hi, I just joined the group. I haven't read enough of this discussion about Auvelity to know if many have had success with it. My psychiatrist is going to be prescribing it for me. I'm 62 years old and have struggled with depression and anxiety all my adult life. Within the last 10-15 years my depression has become resistant to treatment. I had ECT in 2006 and then again in 2019. I had some success but the effects on my memory was horrible. I took many different medications. In the last 3 years I have been battling periodic bouts with suicidal thoughts. Last year I had 36 TMS treatments that had virtually no impact on me. Towards the end of last year I started Spravato treatments. That's the nasal spray version of ketamine. Those treatments are still ongoing but, so far, have had minimal impact on my depression. I'm currently taking trintellix and wellbutrin. I also take klonopin for anxiety. I have not found out if my insurance will cover Auvelity. If it doesn't I may not be able to try it. I have been on disability for my depression for about 2.5 years. I have Medicaid and Medicare. Medicare started prescription coverage last year. It isn't part d. I think it's because I am on disability. Regardless, so far, everything ever prescribed has been covered 100%. I'm hoping Auvelity will be covered too. I am feeling pretty defeated right now. It's not like I have a bad life. I have a great family and awesome friends. Nothing seems to matter anymore. No energy, no interest in anything, feeling isolated from loved ones from my own doing. I really don't know what to do,especially if Auvelity doesn't help. I've had decades of psychotherapy. Please keep me posted on your experiences with Auvelity. Thank you.

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Hi there, I'm only 25 but I have a very similar experience. I did 36 TMS treatments with pretty much no improvement, tried every drug under the sun (probably 20+ meds, including the Trintellix and Wellbutrin) and 15 years of therapy. Wellbutrin gave me a tiny bit of improvement (My depression is a 9 without it, and probably a 7-8 with it) but nothing to write home about. Spravato was my next course of action until learning about Auvelity. I have been on Auvelity for a little over a week, and I have already started to see results. I haven't felt this happy, like.... ever. I've struggled with depression since I was VERY young (signs starting at age 5 or 6) and been on medication since age 10 or 11. I am also on disability and get it covered, thank goodness. It's worth trying.

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Hi,

New to the forum.

Stared auvelity 4 days ago.

Will update in a few days.

Be well,
AK

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@efisk3

Hi there, I'm only 25 but I have a very similar experience. I did 36 TMS treatments with pretty much no improvement, tried every drug under the sun (probably 20+ meds, including the Trintellix and Wellbutrin) and 15 years of therapy. Wellbutrin gave me a tiny bit of improvement (My depression is a 9 without it, and probably a 7-8 with it) but nothing to write home about. Spravato was my next course of action until learning about Auvelity. I have been on Auvelity for a little over a week, and I have already started to see results. I haven't felt this happy, like.... ever. I've struggled with depression since I was VERY young (signs starting at age 5 or 6) and been on medication since age 10 or 11. I am also on disability and get it covered, thank goodness. It's worth trying.

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Wow. Your story caught my eye. I am twice your age and have suffered from depression for most of my life. I also have tried, I believe in the neighborhood of 19-20 medications, two rounds of TMS and some other procedures. Yet here I am, now on disability and struggling with depression still.
My new psychiatrist is “washing “ me off of my meds as I was over medicated with no results. I am now down to just 10 mg trintellix and titrating off of that. The ultimate goal was to try Auvelity. We went through a lot with our insurance to get it- I did secure a prescription. I took it for 3 days and it caused extreme panic. I had to stop it.
But as I read your good results from it and I long to be happy, I wonder if I should try it again. Did you have any increased anxiety? Do you take it with food or at an exact time of day? In other words do you have to be more careful with it than other psychiatric medications?
Any details you could share I would appreciate. Also there have been many drugs over the years that work initially for me but within a very short time they stop working completely. Have you had this experience?
I hope Auvelity continues to make a big difference in your life! Treatment resistant depression is a huge struggle and if you are able to find relief it is a huge gift!

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@bradd106

Hi, I just joined the group. I haven't read enough of this discussion about Auvelity to know if many have had success with it. My psychiatrist is going to be prescribing it for me. I'm 62 years old and have struggled with depression and anxiety all my adult life. Within the last 10-15 years my depression has become resistant to treatment. I had ECT in 2006 and then again in 2019. I had some success but the effects on my memory was horrible. I took many different medications. In the last 3 years I have been battling periodic bouts with suicidal thoughts. Last year I had 36 TMS treatments that had virtually no impact on me. Towards the end of last year I started Spravato treatments. That's the nasal spray version of ketamine. Those treatments are still ongoing but, so far, have had minimal impact on my depression. I'm currently taking trintellix and wellbutrin. I also take klonopin for anxiety. I have not found out if my insurance will cover Auvelity. If it doesn't I may not be able to try it. I have been on disability for my depression for about 2.5 years. I have Medicaid and Medicare. Medicare started prescription coverage last year. It isn't part d. I think it's because I am on disability. Regardless, so far, everything ever prescribed has been covered 100%. I'm hoping Auvelity will be covered too. I am feeling pretty defeated right now. It's not like I have a bad life. I have a great family and awesome friends. Nothing seems to matter anymore. No energy, no interest in anything, feeling isolated from loved ones from my own doing. I really don't know what to do,especially if Auvelity doesn't help. I've had decades of psychotherapy. Please keep me posted on your experiences with Auvelity. Thank you.

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So sorry. I think I get it! I have felt much the same way throughout much of my 77 years. Now I mix really bad back pain with my depression and it’s a helluva bad mix. Depression has been familial in my extended family and I now feel very badly for my children, two of whom are depressives. Nothing I have tried for either depression or pain has been helpful except I do find some relief from alprazolam, though I am very careful about keeping my dosage down. Sure feels like I am in a vice. Like you, I have a great family, good friends, a truly lovely spouse who is so kind and dear. I have shied away from all the newest antidepressants because I am so tired of things not working. I am tuned to the true beauty and wonder of Earth, but my brain is wired wrong somehow…

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