Lubiprostone for IBS-mixed

Posted by letitbe1959 @letitbe1959, Aug 27, 2025

My Gastro Dr has prescribed Lubiprostone 8mcg 2x day for INS mixed. I only take it once a day. It upsets my guts and causes diarrhea. Does anybody have any experience with this med? Should I continue to take it?
Thank you!!!

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Profile picture for letitbe1959 @letitbe1959

Thank you so much for your response. I will mention Linzess to my Dr. I
have a history of anal cancer and surgery/treatment. Didn’t have any
problems prior to that (2012). All they’ll say is that I’m constipated but
I think it’s more complicated than that. Frustrating.

Jump to this post

@letitbe1959
I’m so sorry that you had to deal with anal cancer!
It could possibly have been a factor in your current constipation problem.
It may be a good idea to get a second opinion at a major university medical center- even Mayo- where they deal with more rare illnesses and complications from cancer treatments.
I ended up at Mayo because of GI problems caused by intestinal damage from chemo that wasn’t considered by my local doctors.
There may have been damage to the intestinal nervous system.
Look into major university medical centers or at Hospitals such as Mayo Clinic or Cleveland Clinic.
Keep digging and don’t give up!

REPLY
Profile picture for Ingegerd Enscoe, Alumni Mentor @astaingegerdm

@letitbe1959
I’m so sorry that you had to deal with anal cancer!
It could possibly have been a factor in your current constipation problem.
It may be a good idea to get a second opinion at a major university medical center- even Mayo- where they deal with more rare illnesses and complications from cancer treatments.
I ended up at Mayo because of GI problems caused by intestinal damage from chemo that wasn’t considered by my local doctors.
There may have been damage to the intestinal nervous system.
Look into major university medical centers or at Hospitals such as Mayo Clinic or Cleveland Clinic.
Keep digging and don’t give up!

Jump to this post

Thank you so very much for your kind reply! It didn’t occur to me that I
should pursue another opinion….my symptoms have been minimized for so long
by local doctors. I will look into this. I am retired and don’t have much
money but it may be worth it to travel elsewhere for more experienced
doctors.
😘

REPLY
Profile picture for letitbe1959 @letitbe1959

Thank you so much for your response. I will mention Linzess to my Dr. I
have a history of anal cancer and surgery/treatment. Didn’t have any
problems prior to that (2012). All they’ll say is that I’m constipated but
I think it’s more complicated than that. Frustrating.

Jump to this post

Thank you!

REPLY
Profile picture for letitbe1959 @letitbe1959

Thank you so very much for your kind reply! It didn’t occur to me that I
should pursue another opinion….my symptoms have been minimized for so long
by local doctors. I will look into this. I am retired and don’t have much
money but it may be worth it to travel elsewhere for more experienced
doctors.
😘

Jump to this post

😊

REPLY
Profile picture for Ingegerd Enscoe, Alumni Mentor @astaingegerdm

@letitbe1959
I’m so sorry that you had to deal with anal cancer!
It could possibly have been a factor in your current constipation problem.
It may be a good idea to get a second opinion at a major university medical center- even Mayo- where they deal with more rare illnesses and complications from cancer treatments.
I ended up at Mayo because of GI problems caused by intestinal damage from chemo that wasn’t considered by my local doctors.
There may have been damage to the intestinal nervous system.
Look into major university medical centers or at Hospitals such as Mayo Clinic or Cleveland Clinic.
Keep digging and don’t give up!

Jump to this post

yes aboslsutely keep digging. google everything and then verify they are ligit sites and start putting pieces together. Medical doctors in my opinion seem to have the answer alwasy with a drug which then causes more problems. When if they could just look at what the root cause is and treat it no doubt naturally. Have you tired or considered dietary changes for IBS such as more fiber, better food choices, less fat, increase in movement etc. Those can all make a difference with ibs and many intestinal issues we humans seem to get. (no doubt from the crap food we tend to eat)

REPLY
Profile picture for dlb123 @dlb123

yes aboslsutely keep digging. google everything and then verify they are ligit sites and start putting pieces together. Medical doctors in my opinion seem to have the answer alwasy with a drug which then causes more problems. When if they could just look at what the root cause is and treat it no doubt naturally. Have you tired or considered dietary changes for IBS such as more fiber, better food choices, less fat, increase in movement etc. Those can all make a difference with ibs and many intestinal issues we humans seem to get. (no doubt from the crap food we tend to eat)

Jump to this post

our gut microbiome is a fasnicating garden of bacteria and when one bacteria takes over it can mess things up. And that is true with the bad baceteria and the good bacteria. too much of a good thing isn't always a good thing. And when we add medications to that system guess what the first thing on the list is....may cause upset stomach, nausea and diarreha. Some doctors at least now reccognize that when we take anitbiotics or penicilin etc that it destroys the good bacteria along with the bad that caused the problem. So now we are low on the good stuff and have to repopulate it so they are starting to tell people to take probiotics to help keep the good at least at some level that will make recovery better and keep diarreha at bay. All makes sense when you learn more about it.

REPLY
Profile picture for dlb123 @dlb123

our gut microbiome is a fasnicating garden of bacteria and when one bacteria takes over it can mess things up. And that is true with the bad baceteria and the good bacteria. too much of a good thing isn't always a good thing. And when we add medications to that system guess what the first thing on the list is....may cause upset stomach, nausea and diarreha. Some doctors at least now reccognize that when we take anitbiotics or penicilin etc that it destroys the good bacteria along with the bad that caused the problem. So now we are low on the good stuff and have to repopulate it so they are starting to tell people to take probiotics to help keep the good at least at some level that will make recovery better and keep diarreha at bay. All makes sense when you learn more about it.

Jump to this post

Thank you for this information. 😊

REPLY
Profile picture for dlb123 @dlb123

yes aboslsutely keep digging. google everything and then verify they are ligit sites and start putting pieces together. Medical doctors in my opinion seem to have the answer alwasy with a drug which then causes more problems. When if they could just look at what the root cause is and treat it no doubt naturally. Have you tired or considered dietary changes for IBS such as more fiber, better food choices, less fat, increase in movement etc. Those can all make a difference with ibs and many intestinal issues we humans seem to get. (no doubt from the crap food we tend to eat)

Jump to this post

Yes, I’ve tried those things. Maybe I’m not patient enough bc if they don’t
help after a few weeks, I stop. I won’t give up but it’s frustrating. Thank
you for your help!

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