Connect
Latest Evidence on Active Surveillance Interventions
Evidence.zone is a free resource for men on active surveillance for prostate cancer. Every intervention rated by the strength of the published research — so you know what's proven, what's promising, and what's noise.
Three new interventions this week — and the most important one costs nothing.
Relationship & Intimacy (Connection) — Tier 2, Start. This card is based on research from PC-PEP (Prostate Cancer Patient Empowerment Program) — a comprehensive 6-month home-based programme developed at Dalhousie University that combines relationship and intimacy coaching, stress management, diet, exercise, and pelvic floor training for prostate cancer patients.
Their RCT, published in European Urology, showed the programme significantly reduces psychological distress in men undergoing prostate cancer treatment. PC-PEP is now being implemented internationally across Canada, New Zealand, South Africa, and Romania.
For men on AS, where anxiety is the single biggest reason men abandon surveillance for treatment they may not need, the connection component deserves its own card. Thanks to Rob Rutledge at PCPEP for the suggestion.
Also added: Berberine (Tier 3) — the most coherent preclinical story of any supplement in the library, with a proven bioavailability hack using silymarin.
Fenbendazole (Tier 3) — the veterinary dewormer with genuine lab data but zero human evidence and real safety concerns.
All cards include full study citations, limitations, and an overview.
Like
Helpful
HugInterested in more discussions like this? Go to the Prostate Cancer Support Group.
Connect
Interesting. I take Berberine (1,000 mg/day) for its purported benefit in managing blood sugar. Had no idea of other potential benefits.
@brianjarvis consider combing it with silymarin to increase the bioavailability.
I've been maintaining a free resource — evidence.zone — that rates interventions for men on active surveillance by the quality of the published research. A few things have changed recently that are worth knowing about:
Biggest update: The Pomi-T research has moved on significantly. Professor Robert Thomas's group published a new RCT in European Urology Oncology in 2025 — an upgraded formulation (YourPhyto) combined with a probiotic (YourGutPlus) slowed PSA progression by 44%, with MRI disease stabilising or improving in 91% of patients. It's now the strongest supplement RCT in the active surveillance space.
Also updated: The CAPFISH-3 trial data is now reflected in the Omega-3 card — that's the one published in Journal of Clinical Oncology showing significant reduction in Ki-67 (a proliferation marker) with a high omega-3, low omega-6 diet.
New additions: Cards added for Fenbendazole, Bitter Melon, and Graviola — all three come up repeatedly on forums, so it seemed worth having an honest evidence summary for each.
There's also a new Trials to Watch page covering what's currently in the pipeline — for anyone who wants to know what the next few years of AS research might look like.
Paul
-
Like -
Helpful -
Hug
3 Reactions@paulsweeney What about Menbendazole?
@doyourresearch good call. I've included it now. Thanks for the suggestion:
https://evidence.zone/interventions/mebendazole
@paulsweeney Thank you Paul. I didn't realize I posted it twice, as my first comment was "under review". Have you read the book "Fight Cancer Like a Man" by Dr. Stephen Petteruti? He has an entire chapter on repurposed drugs for prostate cancer. I'm in the process of reviewing them now, but the list he includes in his book is as follows: Sirolimus, Metformin, Low-Dose Naltrexone (LDN), Doxycycline, Atorvastatin, Ivermectin, Menbendazole, Mistletoe (Viscum), and Itraconazole. He explains what they are and why he recommends them. He has an entire other chapter regarding "supplements", which I will focus on after researching the repurposed drug suggestions. He also has a YouTube channel called "Intellectual Medicine". There are many videos on that channel that include information that is worth contemplating. Thank you so much for all your work on this.
-
Like -
Helpful -
Hug
4 ReactionsI am interested in the inclusion of Metformin in his book,I take 3 a day for Diabetes 2 and have managed to reduce this from 5 per day.
My P.S.A,5 years post total prostatectomy is .26 and rise s each 6 monthly test about .02----.3.
Do you think Metformin has helped. ?
Bob Jordan ,Queensland ,Australia
@bobbyjay54321 It may have helped slow it down…or maybe not at all.
But you need SRT soon otherwise you risk losing the chance for metastasis free survival.
You may need ADT as well.
Phil
-
Like -
Helpful -
Hug
2 Reactions@bobbyjay54321 Hi Bob. I do not know, as I do not possess the qualifications to weigh in on that, but thank you for sharing your experience. The more of us who share our experiences, the greater our ability to learn... and to question everything.
In my research, I am finding that repurposed drugs may have a huge role to play in not only cancer, but many other conditions. We have to remember, there is really no financial incentive for mainstream medicine to invest time and resources investigating/promoting alternative uses of existing drugs. Many of them are no longer patented and, consequently, are much cheaper for us to obtain. Many of these repurposed drugs have a long history with well-known "side effects", which seem to be minimal and/or do not last long. Another thing I am learning is that there is a "synergistic" effect when certain repurposed medications are taken together. In the book "Fight Cancer Like A Man", for example, he discusses this synergistic effect.
It is important to work with someone who understands these medications, their mechanisms of action, and safety profiles.
Please continue to research, share your experiences, and stay curious. Thank you Bob!
@heavyphil Hi Phil. Why do you say Bob needs "SRT soon otherwise you risk the chance for metastasis free survival" and "You may need ADT as well"?