Latest Evidence on Active Surveillance Interventions

Evidence.zone is a free resource for men on active surveillance for prostate cancer. Every intervention rated by the strength of the published research — so you know what's proven, what's promising, and what's noise.

Three new interventions this week — and the most important one costs nothing.

Relationship & Intimacy (Connection) — Tier 2, Start. This card is based on research from PC-PEP (Prostate Cancer Patient Empowerment Program) — a comprehensive 6-month home-based programme developed at Dalhousie University that combines relationship and intimacy coaching, stress management, diet, exercise, and pelvic floor training for prostate cancer patients.

Their RCT, published in European Urology, showed the programme significantly reduces psychological distress in men undergoing prostate cancer treatment. PC-PEP is now being implemented internationally across Canada, New Zealand, South Africa, and Romania.

For men on AS, where anxiety is the single biggest reason men abandon surveillance for treatment they may not need, the connection component deserves its own card. Thanks to Rob Rutledge at PCPEP for the suggestion.

Also added: Berberine (Tier 3) — the most coherent preclinical story of any supplement in the library, with a proven bioavailability hack using silymarin.

Fenbendazole (Tier 3) — the veterinary dewormer with genuine lab data but zero human evidence and real safety concerns.

All cards include full study citations, limitations, and an overview.