1. < Prostate Cancer
Profile picture for Paul Sweeney

Latest Evidence on Active Surveillance Interventions

Posted by Paul Sweeney @paulsweeney, Apr 29 4:22am

Evidence.zone is a free resource for men on active surveillance for prostate cancer. Every intervention rated by the strength of the published research — so you know what's proven, what's promising, and what's noise.

Three new interventions this week — and the most important one costs nothing.

Relationship & Intimacy (Connection) — Tier 2, Start. This card is based on research from PC-PEP (Prostate Cancer Patient Empowerment Program) — a comprehensive 6-month home-based programme developed at Dalhousie University that combines relationship and intimacy coaching, stress management, diet, exercise, and pelvic floor training for prostate cancer patients.

Their RCT, published in European Urology, showed the programme significantly reduces psychological distress in men undergoing prostate cancer treatment. PC-PEP is now being implemented internationally across Canada, New Zealand, South Africa, and Romania.

For men on AS, where anxiety is the single biggest reason men abandon surveillance for treatment they may not need, the connection component deserves its own card. Thanks to Rob Rutledge at PCPEP for the suggestion.

Also added: Berberine (Tier 3) — the most coherent preclinical story of any supplement in the library, with a proven bioavailability hack using silymarin.

Fenbendazole (Tier 3) — the veterinary dewormer with genuine lab data but zero human evidence and real safety concerns.

All cards include full study citations, limitations, and an overview.

Interested in more discussions like this? Go to the Prostate Cancer Support Group.

Profile picture for heavyphil
heavyphil | @heavyphil | Jun 15 11:11am
In reply to @doyourresearch "@heavyphil Hi Phil. Why do you say Bob needs "SRT soon otherwise you risk the chance..." + (show)
Profile picture for doyourresearch @doyourresearch

@heavyphil Hi Phil. Why do you say Bob needs "SRT soon otherwise you risk the chance for metastasis free survival" and "You may need ADT as well"?

Jump to this post

@doyourresearch His PSA post prostatectomy after 5 yrs is .26 and rising every six months to now .3…
Treatment for BCR should be initiated at .2 ideally, and favorable outcomes begin to decrease at about .5 - .7 and upward
Current thinking holds that anything lower than .7 ‘may’ not need ADT, but PSMA PET and other factors could change that.
Unless I am reading his statement incorrectly? It was a bit jumbled in terms of timeline snd decimal points…Sorry @bobbyjay, but maybe a little more clarity on what your PSA is NOW, after your surgery years ago? Thanks,
Phil

REPLY
Profile picture for Paul Sweeney
Paul Sweeney | @paulsweeney | Jun 15 5:12pm
In reply to @doyourresearch "@paulsweeney Thank you Paul. I didn't realize I posted it twice, as my first comment was..." + (show)
Profile picture for doyourresearch @doyourresearch

@paulsweeney Thank you Paul. I didn't realize I posted it twice, as my first comment was "under review". Have you read the book "Fight Cancer Like a Man" by Dr. Stephen Petteruti? He has an entire chapter on repurposed drugs for prostate cancer. I'm in the process of reviewing them now, but the list he includes in his book is as follows: Sirolimus, Metformin, Low-Dose Naltrexone (LDN), Doxycycline, Atorvastatin, Ivermectin, Menbendazole, Mistletoe (Viscum), and Itraconazole. He explains what they are and why he recommends them. He has an entire other chapter regarding "supplements", which I will focus on after researching the repurposed drug suggestions. He also has a YouTube channel called "Intellectual Medicine". There are many videos on that channel that include information that is worth contemplating. Thank you so much for all your work on this.

Jump to this post

@doyourresearch super interesting, thank you. I've reviewed the evidence on some of these but not all. I've covered Sirolimus (Rapamycin), Metformin, Ivermectin, Menbendazole, Mistletoe. But I will check out the others. Thanks again.

Paul

REPLY
1 reply
Profile picture for doyourresearch
doyourresearch | @doyourresearch | Jun 15 10:25pm
In reply to @paulsweeney "@doyourresearch super interesting, thank you. I've reviewed the evidence on some of these but not all...." + (show)
Profile picture for Paul Sweeney @paulsweeney

@doyourresearch super interesting, thank you. I've reviewed the evidence on some of these but not all. I've covered Sirolimus (Rapamycin), Metformin, Ivermectin, Menbendazole, Mistletoe. But I will check out the others. Thanks again.

Paul

Jump to this post

@paulsweeney As I quickly perused the evidence.zone site, I did notice that several of your ratings/reviews of those repurposed drugs did not align with Dr. Petteruti's recommendations. In his book, he does cite his rationale for including them, if that is of interest to you. Lots of conflicting information out there, so it's important for everyone to do their own research and revisit as conditions dictate.

REPLY
Please sign in or register to post a reply.