Over the past months my mood has been up and down. My psychiatrist replied that I go on Seroquel, which I was on years ago as well as Zyprexa. When he suggested this, I blurted out “Absolutely not!!!!” I have been on these horrible antipsychotics much of my life. He and I have had discussions about the long term use of these. Not only that but the side effects including weight gain. When I taught school when I was 28, my psychiatrist put me on Mellaril and I gained 40 lbs that year. Years later the newer antipsychotics I took increased my weight enormously to 238 lbs. But my issue is that I have been concerned about whether these drugs have long term effects. I have been looking for a study that covers the years 1940s to present. My psychiatrist says no, and is safe. But I have read books that say on the contrary. I’m on so many medications it’s ridiculous. I’m bipolar, and have stability problems . It’s created a lonely, ghastly spending and in debt, no sex drive, no husband or children, isolated life. Yeah, they really work. I would be most grateful if there is anybody who has any information on studies that have been published by reputable doctors or researchers. I’m turning 65 next month. It’s ugly.