stopping Carvedilol (Coreg): When will the effects wear off?

Posted by teatime @teatime, Apr 28, 2016

Hi everyone,

I am glad to be a part of this community. Please foregive the long post. I was wondering if anyone has had a hard time while being on and going off Carvedilol (Coreg).

I am an active 45 year old mom of a young child. I have always tried to eat healthily and keep in shape (I do yoga, pilates and, run about 5k 2x per week). My BP has always been pretty good, but since my 40´s it has gone up a bit (heredity factors play a role). My BP and heart rate also “spike” when I get stressed or anxious, but for the most part are pretty level during normal times. I do have anxious moments, but I would not say anxiety has been a major life problem. At my last check (Feb 2016), and after wearing a 24 hour BP monitor, my cardiologist suggested I start Carvedilol 6.25 1x per day (quite a low dose) for the spikes and to keep the heart from getting too excited. I agreed that maybe it was a good idea and started over two months ago. Other than stimulating rapid bowel movements, I did not notice any side effects at first. I would say about three to four weeks into taking the Carvedilol, I began not sleeping well. I also noticed my heart pounding, like a bass drum, slowly and steadily, at times. Then the heart pounding began to wake me up at night (it turns out my HR was down in the high 40s at night). Some nights I even felt my chest muscles vibrate, as if a phone on silence mode was on top of my chest. I started to notice this more and more and then I would have a few normal nights, so I figured I would just talk about this at my next cardio check (booked out in June). I also noticed I was getting more and more anxious. I wasn’t too sure why little things were beginning to bother me. I thought it was hormones, PMS, whatever, and started looking for someone like a therapist to talk to.

The previous week was bad. I woke up from a few nightmares and I started to panic in bed, just woken up from sleep. I had three nights of waking up to panic attacks and body shakes. The experiences made me very nervous. At this point I started looking into the side effects of Carvedilol and I was seeing not only chest pounding, but in rare cases reported effects of nightmares, visual disturbances, tremors, anxiety. I also know one does not simply stop a beta blocker, so we talked about tapering down. I tapered down for four days, and then I got in to see another cardiologist on Monday and he said just stop immediately. The effects are rare, but they have been noted. Going off this medication has been frightening. I feel weak and shaky all the time, and I get sporadic periods of pounding and muscle tremors in my legs, anxiety and fuzzy vision. I frequently get so cold I begin to shake. Yesterday I went back to the clinic for an EKG (normal) and some blood tests (including thyroid) and everything was normal. I am just assuming this is my body reacting and readapting itself after being on beta blockers. It has only been five days, but I am wondering if anyone out there has had similar experiences. How long did it take you to feel normal again? I ran a 5k just two weekends ago and yesterday I could hardly take a walk. Thanks for listening.

I am heart attack survivor.Was initially on same dose but in last 4 years I reduced the dose myself .I have also stopped Statins.I belive your symptoms need more of Meditation, Yoga , Exercise and Balanced Diet.Try 3.125 mg Carvediol for 2 weeks.It takes time to adjust the dose.Your other parameters are normal , hence you are doing very good.My Prayers for you.Request your chanting Om Shanti 11 Times Before going to bed and start taking to your heart.It works.Deep Breathing called Pranayam techniques need to be understood and done.We normally live in India and visit US for 4 months in year.
God Bless Kishan Vasekar

@1712aolg

I have only taken Carvedilol 6.25 for 20 days. I had to stop due to anxiety, pounding heart, coughing, sweating and the feeling of fear and panic. Which I have never experienced before! Will I have a problem from stopping the Med. This is my second day off. The cough is horrible but I don’t feel the panic I was experiencing. Called my PC unable to get in. They suggested walk-in Clinic. My BP is higher on the med than off. I feel I need to wait for PC. I am hoping for input from someone with similar experience.

Jump to this post

Hello @1712aolg and welcome to Mayo Connect,

I am so sorry to hear of the difficult symptoms you have experienced with Carvedilol. I can understand your discomfort and wanting to stop the med. However, I would strongly recommend that you talk with your doctor before stopping the Carvedilol completely.

Your doctor may give you a schedule for reducing the dose and may even give you another med to take the place of the Carvedilol.

If you care to share, why were you originally prescribed this med?

Teresa

@1712aolg

I have only taken Carvedilol 6.25 for 20 days. I had to stop due to anxiety, pounding heart, coughing, sweating and the feeling of fear and panic. Which I have never experienced before! Will I have a problem from stopping the Med. This is my second day off. The cough is horrible but I don’t feel the panic I was experiencing. Called my PC unable to get in. They suggested walk-in Clinic. My BP is higher on the med than off. I feel I need to wait for PC. I am hoping for input from someone with similar experience.

Jump to this post

Losartin was causing leg pain. Thank you for your response. I did go to the office earlier today. EKG was normal. Cardio scheduled for Tuesday. No med suggested.

@1712aolg

I have only taken Carvedilol 6.25 for 20 days. I had to stop due to anxiety, pounding heart, coughing, sweating and the feeling of fear and panic. Which I have never experienced before! Will I have a problem from stopping the Med. This is my second day off. The cough is horrible but I don’t feel the panic I was experiencing. Called my PC unable to get in. They suggested walk-in Clinic. My BP is higher on the med than off. I feel I need to wait for PC. I am hoping for input from someone with similar experience.

Jump to this post

Has anyone started Losartin after stopping Carvedilol? Is this a good choice med for hypertension?

@1712aolg

I have only taken Carvedilol 6.25 for 20 days. I had to stop due to anxiety, pounding heart, coughing, sweating and the feeling of fear and panic. Which I have never experienced before! Will I have a problem from stopping the Med. This is my second day off. The cough is horrible but I don’t feel the panic I was experiencing. Called my PC unable to get in. They suggested walk-in Clinic. My BP is higher on the med than off. I feel I need to wait for PC. I am hoping for input from someone with similar experience.

Jump to this post

@1712aolg
I was on the both of them together for about 3 years until I weaned off the carvedilol. I still take Losartin 50mg dose daily. My
bp is always floating both up and down. I can tell instantly when it is heading down to 108/68 as I get horribly exausted and have to walk around or am forced to lie down. The worst is when I am in traffic and it starts its downward spiral.

But the 2 of them do not get in each other's way as far as I could tell.

Elena

@1712aolg

I have only taken Carvedilol 6.25 for 20 days. I had to stop due to anxiety, pounding heart, coughing, sweating and the feeling of fear and panic. Which I have never experienced before! Will I have a problem from stopping the Med. This is my second day off. The cough is horrible but I don’t feel the panic I was experiencing. Called my PC unable to get in. They suggested walk-in Clinic. My BP is higher on the med than off. I feel I need to wait for PC. I am hoping for input from someone with similar experience.

Jump to this post

Thank you got the info.

@1712aolg

I have only taken Carvedilol 6.25 for 20 days. I had to stop due to anxiety, pounding heart, coughing, sweating and the feeling of fear and panic. Which I have never experienced before! Will I have a problem from stopping the Med. This is my second day off. The cough is horrible but I don’t feel the panic I was experiencing. Called my PC unable to get in. They suggested walk-in Clinic. My BP is higher on the med than off. I feel I need to wait for PC. I am hoping for input from someone with similar experience.

Jump to this post

Do you experience leg and or foot pain with the Losartan?

Hi @1712aolg,

I've been taking Losartan for over 10 years, to treat hypertension, and have not experienced any side effects. That being said, many people often go through a trial and error process with regard to blood pressure medications.
I'd also like to invite @faith123 @cynthialoulou @mikegh and @predictable to join in with their thoughts about Losartan. May I ask if you are considering restarting Losartan again?

Thank you for sharing your experience. As a matter fact I did restart the Losartan 50 mg last evening. My BP was scary high. Reading much better this morning. I restarted the 50/12.5 dose this morning. I am hoping for good readings this evening. I am going to pay close attention to when the leg and feet pain starts. I am dearly hopin it doesn’t. . That was my problem when I took the Losartan last time. In your experience is It feasible to do a 50/12.5 in the morning’s and the 50 at bedtime?

@1712aolg

I have only taken Carvedilol 6.25 for 20 days. I had to stop due to anxiety, pounding heart, coughing, sweating and the feeling of fear and panic. Which I have never experienced before! Will I have a problem from stopping the Med. This is my second day off. The cough is horrible but I don’t feel the panic I was experiencing. Called my PC unable to get in. They suggested walk-in Clinic. My BP is higher on the med than off. I feel I need to wait for PC. I am hoping for input from someone with similar experience.

Jump to this post

Hello @1712aolg. Sorry to stick my nose into this discussion. I thought you might like to know about my experience with Carvedilol and Losartan. First, these are very different medications. Losartan is an enzyme secreted by the kidneys to regulate the body's balance of fluids and electrolytes through the renin-angiotensin system, which regulates blood pressure. Carvedilol is a beta blocker which works in the heart (to slow and stabilize heart rate) and the circulatory system (lowering blood pressure); see https://www.drugs.com/carvedilol.html for more information on Carvedilol.

I'm on Carvedilol now (25mg with morning and evening meals) and have no apparent bad symptoms, but several friends have had problems from it, even at doses down to 6.25mg per day. For me, it's especially problematic if I take it within two hours of drinking alcohol. I was on Losartan several years ago, but had to drop it because of a kidney problem it was aggravating. In both cases, the comments and the professional advice I have received argue strongly against making changes in dosage or use of either medication without full involvement of your doctor in your decision or your experimentation. If you have trouble getting in touch with your doctor for a discussion about Losartan and low BP, you may benefit from finding a doctor who will give you a second opinion.

@1712aolg

I have only taken Carvedilol 6.25 for 20 days. I had to stop due to anxiety, pounding heart, coughing, sweating and the feeling of fear and panic. Which I have never experienced before! Will I have a problem from stopping the Med. This is my second day off. The cough is horrible but I don’t feel the panic I was experiencing. Called my PC unable to get in. They suggested walk-in Clinic. My BP is higher on the med than off. I feel I need to wait for PC. I am hoping for input from someone with similar experience.

Jump to this post

@1712aolg
No leg or foot pain accompanying the Losartin.

The foot pain I have suffered with stopped while I was having some PT manual traction on my neck. It was very strange, one day when I put my foot on the floor just as I got out of bed I noticed the pain I'd had for a number of years was gone.

I too am on it now after a few tachycardia bouts due to slight enlargement of left atrium..2 mm.
I've been feeling anxious tired. Lethargy is the side effect it seems plus take 60mg..nifedipine daily. Now feel depressed and sense of humor has evaporated I never actually thought that these were side effects but now after reading your post I'm beginning to wonder…

@tgagnier

I too am on it now after a few tachycardia bouts due to slight enlargement of left atrium..2 mm.
I've been feeling anxious tired. Lethargy is the side effect it seems plus take 60mg..nifedipine daily. Now feel depressed and sense of humor has evaporated I never actually thought that these were side effects but now after reading your post I'm beginning to wonder…

Jump to this post

Hi, @tgagnier. Welcome to Mayo Connect where patients like yourself gather to talk over their medical experiences and share how our experience relates to yours. I was interested in your prescription for Nifedipine at 60mg per day. I also was on calcium-channel blockers about 15 years ago, but at a smaller dosage, and my doctor took me off or it for its tendency to leave fluid in my lower legs and feet. Besides, I didn't then have the heart rhythm problems that calcium-channel blockers also address. When I developed Atrial fibrillation four years ago, my medical team put me on Carvedilol as the main medication for stabilizing my heart rhythm and reducing my blood pressure. In this case, my dosage is 25mg of Carvedilol twice a day. What is your Carvedilol dosage? FYI, it struck me that your Nifedipine dose is pretty large, given that you also are taking Carvedilol. Together, those two drugs pile on a lot of side effects, as you can see at these web sites: rxlist.com/coreg-side-effects-drug-center.htm and medicinenet.com/nifedipine/article.htm.

With the information these web sites provide, you'll be equipped to have a detailed conversation with your doctor about why s/he prescribed each of the medications, why you need them both, why the dosages are so high, and how you can combat the side effects of anxiety, tiredness, lethargy, and depression. Will you be able to get an appointment with your doctor for these purposes?

@cynaburst

I think that it is a bit strange that they would prescribe Coreg for hypertension in the first place. Coreg is a special type of beta blocker with extra properties that make it particularly useful in heart failure and which make the heart pump a little stronger. For someone who was not in heart failure, it seems to me that would be the wrong drug to use though I am not a doctor. Toprol (metoprolol succinate) is one that would seem to be more suitable for that purpose. There are also other classes of drugs that are used to manage hypertension that might be appropriate as well. I might seek a second opinion and see whether that approach was the correct one from the get-go.

Jump to this post

Glad you say that. I have mild LAE with 2 mm dilationand on nifedipine and now carvidilol..3.6 M.G. twice daily. Echo showed no heart failure and an EF of 66% .,EF has gone up from 60% but not sure if this was improved from weight loss and lower BP,or the carvidilol. Sleep poorly now . Feel anxious and jittery at times and depression And I noticed my pulse rate has finally calm down so I’m going to see if I can reduce and finally stop taking the pill altogether if my heart muscle has been able to be repaired to the extent that it does not need to kick in.

Also a cardiologist online tells me with Managing BP in the 125/85 range I can expect 80% chance full reversal of the LAE in six months. Anyone hear of this happening. .?

I had borderline LAE which was on the last year EKG but Dr only Suggested I see a cardiologist but did not tell me why and unfortunately I ignored his advice and things went just fine for another nine months- after a night of partying a vicious dog attack sent me to hospital where I got SVT and went hypertensive for a few hours ..A few nights later I ate four slices of pizza and also got another bout of SVT. This never happened before so guess my borderline LAE was not symptomatic or the attack stretched the atrium just enough to trigger symptoms and an echo cardio gram confirmed a mild left atrial enlargement. I’ve managed to drop 15 pounds my blood pressure is now back in an acceptable range I’ve been on nifedipine for 10 years but was only seriously taking up the last two years so I don’t know if there’s irreversible damage to the atrium or if it can be returned to its original size.

Any one with a comment? I did read the other peoples articles about Corel..not a pleasant drug.

@auntdd

I was placed on carvidiol on Aug 2014, at 3.25 increased to 6.125 where I stayed until Aug 5 of 2016. On that date after very slowly decreasing my dose over time I stop taking carvedilol. For 2 and a half months my BP did great, no problems but just 4 days ago my BP spiked to where I went to the ER. After blood tests and exrays nothing was found. I did not have a heart attack or heart damage but because my BP was 165/75 the er doctors told me to start my carvedilol again. I was so panic that I did and have felt terrible since. Last night I took my BP and it was a low 109/62 with a house of 45 . I never got that low. I never had any symptoms of a heart attack more like a panic attack. I was kept being asked if I had a heart attack eailer when I was put on the medication and no doctor ever told me I did. Although I must have in order to be on this drug, right? Is it normal/usual to have a blood pressure spike so long after being off carvedilol? And do I start it all up again. As for my PCP I have yet to see her, tried to make contact but still no response. I just don’t know what I should do. Please any advice?

Jump to this post

Did you do anything out of ordinary to spike it? It usually does not just shoot up like that .

Please login or register to post a reply.