Hello, I’m looking for information on Methotrexate for Autoimmune Diseases. Checking to see if anyone has experience with side affects and what to expect in terms of recurring joint pain relief. I have Ulcerative Colitis, have had Colitis diagnosis for 33 years and UC diagnosis for 31 years. I’ve lived with the joint pain for more than 15 years and feel it’s time for some relief. Till now I’ve had prednisone tapers off and on since 2012 and the past 6 months have been fortunate to have a few weeks here and there where I’ve not had joint pain. Most of the time I manager with ice packs, compression and if I’m lucky can take Tramadol at night with Tylenol (depends weather I need to work the next day or not). Any information would be greatly appreciated.