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Hashimotos and Low Dose Naltrexone (LDN)
I was just diagnosed with Hashimoto at age 76 but believe I have had it much longer. I had been on synthroid for hypothyroid for over 40 years. I have dealt with depression for most of my life. Last year I went to a MD who uses more of a functional approach who ran full thyroid panel. I was put on NP Thyroid and began LDN at 1.5 mgs and am now on 3.5 mgs with hope of ending up at 4.5 mgs. So far I am not feeling an improvement. Have extreme fatigue and not able to lose weight. Has anyone tried LDN?
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I have not but I'm very intrigued by this and just wrote down to search for an integrative endocrinologist for my Hashimoto's which gifts you with Hypothyroidism. Went on levothyroxine and conventional docs says, TSH, T3 & T4 All good, you're all good. No I'm not, I should not feel this fatigued, depressed a lot from having lack of energy and im a doer. Diagnosed about 3 years ago after years of mystery and all sorts of testing. I'm 63 now and like my Mom, I want to ski, hike etc well into my 80s or 90s god willing.
Keep us posted on your journey, I'm going to do some research!
Stay strong 💪 🤘 ❤️
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1 ReactionI'm on 3mg LDN as a bridge from a fast prednisone taper until I can start kevzara. I have been taking prednisone for PMR but a subsequent SMM diagnosis requires a fast taper and switch to kevzara. I take my LDN at night and it helps me sleep with less pain.
As a long covid and hypothyroid person, I tried LDN almost 2 years ago. If I stay away from triggering foods, my pain is down at least 50% and I can lose weight again. I sleep better (probably due to the pain relief), have less fatigue and my immune system seems overall better regulated...which is good for what ails you! LDN really works on inflammation which is a blessing for me!
You do have to start low and will have some mild side effects...I had vivid wild dreams (no nightmares) for about two weeks, made me sleepy for about a month and then gave me insomnia so I now take it first thing in the morning. And you have to work to find the right dose for your body...some are better at .25 mg or .5 mg, others need 3 or 4 mg and I need 5-6 mg.
You do a slow titrate usually starting at 1.5 mg and increasing 1.5 mg a month with a goal of 4.5 mg. I had LDN formulated at the local compounding pharmacy into a liquid so it is easy for me to change the dose. If 1.5 is too much, start at a much lower dose and work up. I started feeling better at 3 and got much getter by the time I got to 4.5 mg.
I have had thyroid issues most of my life. Believe symptoms showed in college at 22 when a throat specialist examined my neck and mentioned enlargement but never referred me to an endocrinologist . So, I had my tonsils removed. It was not until my 50's thatI was diagnosed. Even then they could not tell me how I got this. It wasn't until I found an endocrinologist and wa told it was Hashimoto disease which runs in the maternal side of my family. I have been on Synthroid since. Would like to know what this LDN is.
I've been on LDN for about 7 yrs now and I credit it for putting my Crohn's(40yrs) in remission. It will help more than 80 % of Crohn's people but Hashimtos, I don't know. I take 2mg at bedtime.
@gymnast1
https://ldnresearchtrust.org/what-is-low-dose-naltrexone-ldn
This website has very good information.
Low dose Naltrexone has been helpful for many people. It is the only thing that has worked for my rheumatoid arthritis.
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1 Reaction@suetex
"I've been on LDN for about 7 yrs now and I credit it for putting my Crohn's(40yrs) in remission."
Possible: It works as an anti-inflammatory, differing from standard doses by temporarily blocking receptors to boost endorphin production. Clinical trials show it can aid mucosal healing and induce remission with few side effects.
Low dose Naltrexone for induction of remission in inflammatory bowel disease patients
https://pmc.ncbi.nlm.nih.gov/articles/PMC5845217/