Has anyone found a treatment that helps with peripheral neuropathy?

Opioids work for me. I also take Duloxetine and it helps a little bit but the opioids take away almost all of my pain. I tried pretty much everything else and none of it worked and even tried physical therapy. It was suggested to try acupuncture but figured it was a waste of my time.

Pallative care orginally prescribed my opioids but they started to get weird and was pushing me to go to pain management. Hospital pain management stinks and they won't listen to you and good luck trying to get them to prescribe any opioids.After 9 months I had to go to an independent pain management clinic and got my opioids prescription through them.

This is not a cure however it does align with what I have seen and may be useful.

1. Cortisol Drops in the Evening
Cortisol is your body's natural anti-inflammatory hormone. It peaks in the morning to help you wake up and steadily drops to its lowest levels in the evening to prepare you for sleep. As your cortisol levels fall during the late afternoon, your body’s natural ability to suppress nerve inflammation and pain signals decreases.
2. Melatonin and Core Temperature Changes
As evening approaches, your brain begins releasing melatonin, and your core body temperature starts to shift. These metabolic changes interact directly with damaged sensory nerve fibres, often making them hyper-reactive and causing burning, tingling, or electric sensations to spike.
3. The "Distraction" Factor
During the day, your brain is busy processing sights, sounds, work, and movement. This mental activity acts as a natural filter, blocking out some of the pain signals coming from your small nerve fibres. In the evening, as your environment quiets down, this sensory distraction disappears. Your brain suddenly registers the pain signals much more clearly, making the pain feel significantly more intense even though the physical state of the nerves hasn't changed.

Thanks for your comment, what opioid did you get prescribed. If can advise would be interesting to know. Thank you arvin.t@btinternet.com

Can anyone advise if Magnesium supplement has helped and what strength mg did you take.? Thanks Arvin

@arv10 I would be interested also since opioids did not help me.

I have been a inpatient several times in hospital and they , compression socks knee high are compulsory and if any patients refuse they are forced to wear. Hence, there is a clear positive sign. Regards Arvin

@mjpn2012 cortisol drops are cortisone-steroids. I am in high dose steroids for an autoimmune condition and that actually causes my foot neuropathy. Mama Bear magnesium cream gives excellent relief so does CeraVe itch Relief lotion. They must be rubbed in well. Wear wool socks to bed and light support hose - Bombas Cotton support hose excellent.

Hello all, here is my experience. My personally developed treatment for PN are lotions with Aloe Vera extract possibly with Cucumber extract as well. I treat my feet, ankles and lower legs with such lotion and generously apply the lotion so it lasts all day until evening.

@arbie v10 Be sure there is no B6 in your magnesium an elevated B6 causes neuropathy too. Only get your B6 from food.

@bckgeo47
Can you name what you use?