Has anyone found a treatment that helps with peripheral neuropathy?

Posted by bigjohnscho @bigjohnscho, Jul 1, 2025

I suspect that everyone on this forum has been searching for a medication that helps their neuropathy and even though you no that all the internet claims are false we continue to waste hundreds of pounds. Desperation is a powerful force. Has any one been fortunate enough to find a genuine treatment. I just can’t believe that there are so many awful people who prey on our vulnerability and knowingly orchestrate such elaborate scams.

Interested in more discussions like this? Go to the Neuropathy Support Group.

Profile picture for cit10jetjockey @cit10jetjockey

Save your money. There’s no treatment for PN, and there will never be any. The nerves are damaged and they are not going to heal. If you have pain, drugs help, then there are others who have no pain, they just stumble around. All you can do is live with it as it will never get better.

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@cit10jetjockey
When I was 15 I cut my finger. I had no feeling from the scar to my fingertip, about 2" distance. I was told that nerves do not heal or regrow. When I was 23 i woke up one morning to insane tingling in that finger. The tingling lasted for months but then it all settled down. All my feeling in that finger had returned. Nerves can heal and can regrow.

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Profile picture for roncapstraw @roncapstraw

I use AMLA and my pins and needles have stopped !
I take two in the morning and haven't had a problem since .
I am very CHEAP and found that EBAY is the least costly.

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@roncapstraw do you buy the R AMLA or the regular AMLA ? I was advised there could be a difference in effectiveness

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Profile picture for greengold @greengold

@katdens
You may not be diabetic but have you possibly been in the pre-diabetic range for a long time?

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@greengold No issues with blood sugar. Overall, I feel self-centered for complaining about PN, because I am incredibly healthy otherwise. My bloodwork and so on goes to the Cleveland Clinic and says I am doing great. My mother and father didn't have it and my sister (75) doesn't have it. Guess I am just the chosen one. 🙂

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I'm 59. I am a diabetic since 2017 (A1C 8.7 - 10.7)and with major peripheral neuropathy which started with my toes (tingling, numb, etc..) in 2018. Until this day(2026), I have dealt with incurable, unmanageable, uncontrollable diabetes II and painful body peripheral neuropathy which has drastically grown and broaden from toes, feet, calves, thighs, waist to hands(fingers) which also brings sudden and sporatic extreme painful nerve lightning strikes.

After all the doctors, neurologist, specialist, emergency rooms, hospitals, prescribed medications such as (Pregabapentin/gabapentin, Juniva, Metformin, Duloxetine, 4 different injectable insulins, etc.. along with expensive massagers, creams, medical devices, and stuff such from Internet, Amazon and eBay to help with neuropathy at no avail which also and eventually brings major depression and weakness, abdomen pain, insomnia and not to mention, major anxiety.

As of today, I regret to spend thousands and thousands of dollars (Out of Pocket and/or Insurance) for diabetes, body neuropathy, along with the other medicatins for all their symptoms it brings to your mental and physical stages.

With disability claims denials, I am still forced to work to pay bills, and continue to live otherwise move to the streets. Not to mention, most employers seriously ignore and/or support your medical conditions even with ADA. I attempted to register for housing, funding, etc.. several times but it seems it is a waste of effort, time and energy.

Unfortunately and sadly, these serious mental and health complications and conditions were experienced as "NO CURE" ! The final solution mentioned by a honest emergency doctor was to amputate feet, and legs, and hands. There was some serious thought about it but ultimately refused the final solution.

After 8 years with such conditions and serious advise, you DO NOT want the neuropathy (PN-nerve damage) to grow, spread and affect your entire feet, calves, thighs, waist and hands as it is an extremely uneasy, painful, frustrating state of mind, serious anxiety, stress, etc. with daily activities... And not to mention, impotent for the last 7 years and specialized doctor(s) want 30K to make you believe that they can help with it. I declined!

From many years of experience, I found NO devices, creams, massagers, meds, specialist, doctors, etc. for PN and diabetes. Sadly, I have molded and learned to ignore ALL awful symptoms as it has been a part of my life for many years. And believe me, it is an extremely miserable way to live into the golden years and rest of your life......

As I feel daily discomfort and accepted "NO CURE", I purchased a 2 year dog (German Shepherd) to help encourage, motivate, smile, and walk at least 4 times a week which brings little help with body movements, muscles, and seldomly nerves regardless of the pain. He is amazing! I completely regret not doing so many years ago...as i still want to live a bit longer...or until I can no longer bare the body pain.

My advice is to eat healthy, daily walks, "exercise', remain optimistic and possibly adopt a dog for major encouragement, motivation, daily routine walk exercises, smiles, happiness, and most definitely "Save your Money" until maybe one day medical field will find a permanent solution for all experiencing these awful and serious mental and health conditions as I age. Ultimately, I am scared that all mental and physical symptoms will worsen before improving in my life time.

My prayers are with all of you …

A Man of No Cures!

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Profile picture for Beach @michhino

I'm 59. I am a diabetic since 2017 (A1C 8.7 - 10.7)and with major peripheral neuropathy which started with my toes (tingling, numb, etc..) in 2018. Until this day(2026), I have dealt with incurable, unmanageable, uncontrollable diabetes II and painful body peripheral neuropathy which has drastically grown and broaden from toes, feet, calves, thighs, waist to hands(fingers) which also brings sudden and sporatic extreme painful nerve lightning strikes.

After all the doctors, neurologist, specialist, emergency rooms, hospitals, prescribed medications such as (Pregabapentin/gabapentin, Juniva, Metformin, Duloxetine, 4 different injectable insulins, etc.. along with expensive massagers, creams, medical devices, and stuff such from Internet, Amazon and eBay to help with neuropathy at no avail which also and eventually brings major depression and weakness, abdomen pain, insomnia and not to mention, major anxiety.

As of today, I regret to spend thousands and thousands of dollars (Out of Pocket and/or Insurance) for diabetes, body neuropathy, along with the other medicatins for all their symptoms it brings to your mental and physical stages.

With disability claims denials, I am still forced to work to pay bills, and continue to live otherwise move to the streets. Not to mention, most employers seriously ignore and/or support your medical conditions even with ADA. I attempted to register for housing, funding, etc.. several times but it seems it is a waste of effort, time and energy.

Unfortunately and sadly, these serious mental and health complications and conditions were experienced as "NO CURE" ! The final solution mentioned by a honest emergency doctor was to amputate feet, and legs, and hands. There was some serious thought about it but ultimately refused the final solution.

After 8 years with such conditions and serious advise, you DO NOT want the neuropathy (PN-nerve damage) to grow, spread and affect your entire feet, calves, thighs, waist and hands as it is an extremely uneasy, painful, frustrating state of mind, serious anxiety, stress, etc. with daily activities... And not to mention, impotent for the last 7 years and specialized doctor(s) want 30K to make you believe that they can help with it. I declined!

From many years of experience, I found NO devices, creams, massagers, meds, specialist, doctors, etc. for PN and diabetes. Sadly, I have molded and learned to ignore ALL awful symptoms as it has been a part of my life for many years. And believe me, it is an extremely miserable way to live into the golden years and rest of your life......

As I feel daily discomfort and accepted "NO CURE", I purchased a 2 year dog (German Shepherd) to help encourage, motivate, smile, and walk at least 4 times a week which brings little help with body movements, muscles, and seldomly nerves regardless of the pain. He is amazing! I completely regret not doing so many years ago...as i still want to live a bit longer...or until I can no longer bare the body pain.

My advice is to eat healthy, daily walks, "exercise', remain optimistic and possibly adopt a dog for major encouragement, motivation, daily routine walk exercises, smiles, happiness, and most definitely "Save your Money" until maybe one day medical field will find a permanent solution for all experiencing these awful and serious mental and health conditions as I age. Ultimately, I am scared that all mental and physical symptoms will worsen before improving in my life time.

My prayers are with all of you …

A Man of No Cures!

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@michhino

“I attempted to register for housing, funding, etc.. several times but it seems it is a waste of effort, time and energy.”

This is very true and no one knows how hard or impossible it is to get help until they have looked into it themselves. There really is no help as I have learned as I am going through this now. The only unhelpful advice for anyone I have is to not get seriously ill or pick up a condition while you are still of working age. If you are lucky enough that is. It is quite the rude awakening what you will find out dealing with medical professionals, social workers etc…..

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Profile picture for flaherty2185 @flaherty2185

Has any research been done on benefits of psilocybin in treating of onset of peripheral neuropathy during came out therapy?

I saw an article in the New York Times that there was some current studies underway. The same article indicated that psilocybin may possibly have some benefits for neuropathy following chemo therapy.

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@flaherty2185 here’s some research notes on the subject
Check out this answer from MediSearch! https://medisearch.io/share/3s13JtLVyUrVqosbW3VYMb

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