Anyone else on Daraxonrasib (RMC-6236)?

Posted by howleegirl @howleegirl, May 8 5:59am

Waiting for the approval for my husband to start daraxonrasib. (the new and exciting drug just fast tracked by the FDA) Doc says he's a great candidate for this drug. Anyone else on this? I know about the awful rash you get from seeing the senator on TV. Doc has also styopped all treatment since April 11th. THAT kinda scares me?

Interested in more discussions like this? Go to the Pancreatic Cancer Support Group.

howleegirl | @howleegirl | May 20 10:10am

In reply to @mnewland99 "@scullen53 My dr applied. I'm with UCI, not Mayo. She told me the process can take..." + (show)

@mnewland99 Our doctor said the same thing.

marienewland | @mnewland99 | May 20 9:16am

In reply to @scullen53 "My brother has stage 4 pancreatic cancer, he has asked his MD about Daraxonrasib after it..." + (show)

@scullen53
My dr applied. I'm with UCI, not Mayo. She told me the process can take about 2 months.

Turkey, Volunteer Mentor | @tomrennie | May 20 7:21am

In reply to @scullen53 "My brother has stage 4 pancreatic cancer, he has asked his MD about Daraxonrasib after it..." + (show)

@scullen53 Hi and welcome to Mayo Connect. Here is the process from the manufacturer's website. So you are finding it to be different?
https://www.revmed.com/expanded-access-policy/

scullen53 | @scullen53 | May 19 8:28pm

My brother has stage 4 pancreatic cancer, he has asked his MD about Daraxonrasib after it was granted expanded access by the FDA. He was told it still had to be approved by Mayo?! That doesn't sound correct to me. My understanding was that the oncologist needs to apply to Revolution Medicines to obtain it. Does anyone understand what the process is? Thanks

strongone21 | @strongone21 | May 18 8:24pm

In reply to @gsf "@strongone21 Thank you for that information and good to hear you believe the side effects are..." + (show)

@gsf Sorry I misunderstood. I see that metastasis is a requirement for Daraxonrasib EAP access.

gsf | @gsf | May 18 5:33pm

In reply to @strongone21 "@gsf I agree with @gamaryanne. Waiting till it metastasizes might make it harder. Side effects are..." + (show)

@strongone21 Thank you for that information and good to hear you believe the side effects are manageable. I wrote "if her cancer metastasizes" since I think, from what I've been reading, that this is required for both the trials and for the FDA limited release of Daraxonasrab.

strongone21 | @strongone21 | May 18 3:55pm

In reply to @gsf "@gamaryanne @gamaryanne Have the people you know in the trial for this drug had good results?..." + (show)

@gsf I agree with @gamaryanne. Waiting till it metastasizes might make it harder. Side effects are manageable and doctors are good about proactively treating them. At this point, getting in a trial with this drug is a lot harder than the side effects itself, so if she can get in it is definitely worth it.

gamaryanne | @gamaryanne | May 15 6:39am

Yes, definitely. Shrinkage and maintenance preventing future growth has been seen in many people. I also had shrinkage and was not on the current approved dosage (I was in a phase 1 clinical trial). Two things about the side effects: 1)because of clinical trials, doctors have topicals and prescriptive drugs to offer to control skin side effects upfront
2) not everyone experiences the side effects dramatically. Dosages may be managed and escalated as patients adjust to it.

Ben Sasse is not a typical example of the effects of this drug. He is most likely taking the max dose along with chemo, probably fulfurinox. She should not be scared of it based on his expose.

gsf | @gsf | May 14 8:21am

In reply to @gamaryanne "Please know that while the skin issues are annoying, the company has found several different topical..." + (show)

@gamaryanne @gamaryanne Have the people you know in the trial for this drug had good results? Have they seen their tumors shrink? My wife has the KRAS G12D mutation so would be a good candidate if her cancer metastasizes, but she is a little afraid of the side effects---not just the rash but other ones as well. Thank you in advance for a reply. Your posts have been helpful.