Daraxonrasib

My daughter has pancreatic cancer and has had the #2 chemo but it didn't help. Now they are waiting for the Daraxonrasib pill. Why the wait? It seems Duke would be able to get the pill when needed. Anyone have anything to say as why the wait?

@owlladycpl
after her doc fills out the application it has to be approved by the manufacturer. We are waiting too!

Please know that while the skin issues are annoying, the company has found several different topical creams and prescription antibiotics that can head the worst of this off. Ask for these upfront. Also. This drug is not FDA approved so they have to supply it directly. They are not a large scale manufacturer so this may take a little time to disperse.
I know many people that have been in the trial for the drugs over 2 years! They have found ways to deal with the skin so don’t let that create too much anxiety !

@owlladycpl Did Duke say they can give you the pill? It is not available without trial qualification and approval from Rev Med drug company.

Is this drug specific to the KRAS mutation? Is it being also tested on non-KRAS patients?

A drug nearing regulatory approval, daraxonrasib, is the first to substantially extend the lives of patients with pancreatic cancer. It works by targeting a cellular protein that fuels not just nearly all pancreatic tumors, but also many lung and colon cancers. Those three are the leading causes of cancer deaths.
Marylyn new article

@alanbeavfan this is only for KRAS mutations from what I know.

@gamaryanne @gamaryanne Have the people you know in the trial for this drug had good results? Have they seen their tumors shrink? My wife has the KRAS G12D mutation so would be a good candidate if her cancer metastasizes, but she is a little afraid of the side effects---not just the rash but other ones as well. Thank you in advance for a reply. Your posts have been helpful.

Yes, definitely. Shrinkage and maintenance preventing future growth has been seen in many people. I also had shrinkage and was not on the current approved dosage (I was in a phase 1 clinical trial). Two things about the side effects: 1)because of clinical trials, doctors have topicals and prescriptive drugs to offer to control skin side effects upfront
2) not everyone experiences the side effects dramatically. Dosages may be managed and escalated as patients adjust to it.

Ben Sasse is not a typical example of the effects of this drug. He is most likely taking the max dose along with chemo, probably fulfurinox. She should not be scared of it based on his expose.