Anyone else on Daraxonrasib (RMC-6236)?

@tomrennie: I get started with an antibiotic and two creams on Wednesday (tomorrow) and the daraxonrasib on Thursday. Hoping that the side effects won't be too nasty....

@nbcesq What day this week do you start?

@mcoplien try to explore nearby states as that will give you the best possibility.

I'm scheduled to start daraxonrasib this week, at Johns Hopkins. I've had some progression of metastatis to the liver and lungs on 5 F/U + irinotecan (the last chemo regimen remaining for me), so this new medication has come at just the right time for us! Obviously, I can't say what it's like being on the drug yet, but it's clear that there are a number of side effects possible. I'll need to return to JHH every couple of weeks to have those monitored, so that they can adjust my levels, as needed. I'm hoping that your husband will be approved for the Expanded Access Program, too. Every good wish to you!

Thank you all for your discussions and helpful suggestions here. My fiancé was diagnosed with stage 4 pancreatic cancer on the tail but metastasized to the liver in Sept 2025. He has gone through 12 rounds of FOLFIRINOX which shrank the cancer on the tail of his pancreas from 2.9 cm to 1.1 cm after 6 rounds. His UCI oncologist then ordered radiation treatments on the pancreas tail and Y90 on his livers. However, he started to have ascites about 3 weeks ago and had 3 parenthesis already so far as the fluids are accumulating very fast causing extreme pains in his lower abdomen and inability to eat…… He is on OTC Tylenol which helps to some extent. His oncologist is processing for daraxonrasibs but it seems to be taking long. Does any one of you have similar pain experience and any suggestions? I am thinking of taking him to Emergency Room to get some help. Any suggestions are highly appreciated. He is 65 years old and was quite healthy before this was discovered by accident. God bless you all!🙏

@panacea I am waiting for the pill. The Cancer Center I am at Carbone in Madison WI has submitted be as a candidate for the PILL but not pill yet, they say it will be end of July or end of Summer before I get it. I am not sure anyone has got it yet as part of the expanded trial.

Hello friends, as many know I was in an early trial of the revolution medicine drugs. From that, I have continued in a community of patients -some who have been on the drugs for 24 months or more! Many therapies have been tried and now prescribed for the skin issues. Some people experience irritation more than others. I am no longer a candidate for any KRAS trials but if someone is on it struggling with the skin issues pls reach out and I will pass along things now being prescribed so you can ask your doctors .

Please give any info on effectiveness of new REvolution drug vs chemo or other treatment options