Anyone else on Daraxonrasib (RMC-6236)?

@panacea I am waiting for the pill. The Cancer Center I am at Carbone in Madison WI has submitted be as a candidate for the PILL but not pill yet, they say it will be end of July or end of Summer before I get it. I am not sure anyone has got it yet as part of the expanded trial.

Thank you all for your discussions and helpful suggestions here. My fiancé was diagnosed with stage 4 pancreatic cancer on the tail but metastasized to the liver in Sept 2025. He has gone through 12 rounds of FOLFIRINOX which shrank the cancer on the tail of his pancreas from 2.9 cm to 1.1 cm after 6 rounds. His UCI oncologist then ordered radiation treatments on the pancreas tail and Y90 on his livers. However, he started to have ascites about 3 weeks ago and had 3 parenthesis already so far as the fluids are accumulating very fast causing extreme pains in his lower abdomen and inability to eat…… He is on OTC Tylenol which helps to some extent. His oncologist is processing for daraxonrasibs but it seems to be taking long. Does any one of you have similar pain experience and any suggestions? I am thinking of taking him to Emergency Room to get some help. Any suggestions are highly appreciated. He is 65 years old and was quite healthy before this was discovered by accident. God bless you all!🙏

I'm scheduled to start daraxonrasib this week, at Johns Hopkins. I've had some progression of metastatis to the liver and lungs on 5 F/U + irinotecan (the last chemo regimen remaining for me), so this new medication has come at just the right time for us! Obviously, I can't say what it's like being on the drug yet, but it's clear that there are a number of side effects possible. I'll need to return to JHH every couple of weeks to have those monitored, so that they can adjust my levels, as needed. I'm hoping that your husband will be approved for the Expanded Access Program, too. Every good wish to you!

@mcoplien try to explore nearby states as that will give you the best possibility.

@nbcesq What day this week do you start?

@tomrennie: I get started with an antibiotic and two creams on Wednesday (tomorrow) and the daraxonrasib on Thursday. Hoping that the side effects won't be too nasty....

@strongone21 How would a nearby state give someone the best possibility?

@tomrennie in our case, we first got enrolled in the clinical trial through a hospital at a nearby state. Then they transferred our file back to our own hospital, as our hospital did not have the right resources pulled in for us to work on it. So my suggestion is not to wait just for your hospital to keep trying for the trial, but also check with others near you who are willing to try harder.