COPD and Emphysema: Want to connect with others

Posted by redsox @redsox, May 29, 2018

Confused by PFT so much to absorb ! What are the treatments for Mild, Moderate and Severe .

@merpreb

@clipper– Hello. This is very interesting. Are there studies that you can point me to that indicate that they don't work? I'd love to read more about this procedure.

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@merpreb There are no clinical studies, it can’t even get that far but there is early research and they are making progress. There have been a few articles on the topic but no true clinical studies, it’s just not there yet. I have to run now but this afternoon I will dig some of those links and post them.

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@clipper– Thank you

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@merpreb

I hope my posts weren't too abrupt, I was rushing to get out the door. I also didn't mean to imply it won't ever work, just that the companies selling stem cell therapy today have not undergone robust clinical studies showing it to be effective. All the class action lawsuits against the company selling it in the US would suggest otherwise.If you look at where the real science is today, it is very hard to imagine that anyone has a full blown successful stem cell therapy for lung disease.

I also need to correct something, there are clinical studies underway. There are 39 clinical studies, 14 are active. There are 12 studies that have completed, only two have published results. When results are published, it is usually because they don't have any. One of the two is the Lung Institute, the company that the FDA is trying shut down. The other one was a study done in Brazil and was legit but it was an open, non-randomized study with only 4 patients. It doesn't much look like much came from that.

However there is a lot of valid research going on so it remains hopeful. Here are some useful links I tried to keep it current, nothing older than 2017.

Feb 2018 Researchers have identified a lung stem cell that repairs the organ's gas exchange compartment, according to a new study from the Perelman School of Medicine at the University of Pennsylvania.
https://www.sciencedaily.com/releases/2018/02/180228131106.htmhttps://copdnewstoday.com/2018/03/06/copd-newly-identified-stem-cells-can-restore-lung-alveoli-mice/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146161/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864644/
https://med.stanford.edu/news/all-news/2017/11/researchers-find-lung-stem-cell-heal-lung-injury-in-mice.html
https://www.pulmonologyadvisor.com/home/topics/copd/adipose-tissue-transfer-lung-scaffolds-the-future-of-stem-cells-in-copd/2/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829274/

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@clipper

@merpreb

I hope my posts weren't too abrupt, I was rushing to get out the door. I also didn't mean to imply it won't ever work, just that the companies selling stem cell therapy today have not undergone robust clinical studies showing it to be effective. All the class action lawsuits against the company selling it in the US would suggest otherwise.If you look at where the real science is today, it is very hard to imagine that anyone has a full blown successful stem cell therapy for lung disease.

I also need to correct something, there are clinical studies underway. There are 39 clinical studies, 14 are active. There are 12 studies that have completed, only two have published results. When results are published, it is usually because they don't have any. One of the two is the Lung Institute, the company that the FDA is trying shut down. The other one was a study done in Brazil and was legit but it was an open, non-randomized study with only 4 patients. It doesn't much look like much came from that.

However there is a lot of valid research going on so it remains hopeful. Here are some useful links I tried to keep it current, nothing older than 2017.

Feb 2018 Researchers have identified a lung stem cell that repairs the organ's gas exchange compartment, according to a new study from the Perelman School of Medicine at the University of Pennsylvania.
https://www.sciencedaily.com/releases/2018/02/180228131106.htmhttps://copdnewstoday.com/2018/03/06/copd-newly-identified-stem-cells-can-restore-lung-alveoli-mice/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146161/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864644/
https://med.stanford.edu/news/all-news/2017/11/researchers-find-lung-stem-cell-heal-lung-injury-in-mice.html
https://www.pulmonologyadvisor.com/home/topics/copd/adipose-tissue-transfer-lung-scaffolds-the-future-of-stem-cells-in-copd/2/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829274/

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I looked into stem cell treatment a while back. My pulmonoligist was definitely not on board. The patient coordinator was pretty helpful. His name was Sal Ingrassia. The lung Institute. I think they have multiple locations.

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there is good news there is STEM CELL and now ZEPHER VALVES talk to your doctors about these new break thru devices. good luck god bless you all. I have copd myself.

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@clipper

@merpreb

I hope my posts weren't too abrupt, I was rushing to get out the door. I also didn't mean to imply it won't ever work, just that the companies selling stem cell therapy today have not undergone robust clinical studies showing it to be effective. All the class action lawsuits against the company selling it in the US would suggest otherwise.If you look at where the real science is today, it is very hard to imagine that anyone has a full blown successful stem cell therapy for lung disease.

I also need to correct something, there are clinical studies underway. There are 39 clinical studies, 14 are active. There are 12 studies that have completed, only two have published results. When results are published, it is usually because they don't have any. One of the two is the Lung Institute, the company that the FDA is trying shut down. The other one was a study done in Brazil and was legit but it was an open, non-randomized study with only 4 patients. It doesn't much look like much came from that.

However there is a lot of valid research going on so it remains hopeful. Here are some useful links I tried to keep it current, nothing older than 2017.

Feb 2018 Researchers have identified a lung stem cell that repairs the organ's gas exchange compartment, according to a new study from the Perelman School of Medicine at the University of Pennsylvania.
https://www.sciencedaily.com/releases/2018/02/180228131106.htmhttps://copdnewstoday.com/2018/03/06/copd-newly-identified-stem-cells-can-restore-lung-alveoli-mice/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6146161/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864644/
https://med.stanford.edu/news/all-news/2017/11/researchers-find-lung-stem-cell-heal-lung-injury-in-mice.html
https://www.pulmonologyadvisor.com/home/topics/copd/adipose-tissue-transfer-lung-scaffolds-the-future-of-stem-cells-in-copd/2/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829274/

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@clipper– good morning. I didn't find that you were abrupt at all. Thank you for your hard work in your research. What a wealth of information and hope you have given all of us. Thank you. It's exciting to see medical advances happen in front of your eyes isn't it! To be able to freely breathe again, or near it is the future!

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@merpreb

@clipper– good morning. I didn't find that you were abrupt at all. Thank you for your hard work in your research. What a wealth of information and hope you have given all of us. Thank you. It's exciting to see medical advances happen in front of your eyes isn't it! To be able to freely breathe again, or near it is the future!

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@merpreb
Morning. There is lots of really great research going on. We should all have hope, real science is amazing and the field of regenerative medicine will get us there.

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Hip Hip Hooray @clipper! You are right on target!

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@marczappa

Just joined to try and see if COPD/ Asthma, Emphysema can be helped by Stem Cell treatments . While medication has helped somewhat I am uncomfortable and short of breath most of the time.

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Marc; I've read Dr. Morrisey at Penn University found that AEP stem cells will regrow alveoli in mice. I also read where Mayo can produce millions of stem cells quickly. I would like them to get together and see if they could help each other find a cure.

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@jgpolachek

Marc; I've read Dr. Morrisey at Penn University found that AEP stem cells will regrow alveoli in mice. I also read where Mayo can produce millions of stem cells quickly. I would like them to get together and see if they could help each other find a cure.

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A few years back I read some Japanese scientist discovered the same thing in mice and that more studies needed to be done. From what I've seen stem therapy doesn't seem to be toxic. It may not work but shouldn't kill you. Maybe I'm wrong but if not why can't the step up the pace?? I'm ready to be a human mouse 🙂

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bb729; they all seem to give hope then pull rug out. The best lung Dr. I ever seen once told me I don't want you to give up hope, but remember there is no money in cures. He also said big Pharma control trials and a lot of doctors.

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@jgpolachek– Welcome to Mayo Connect. I am a volunteer mentor with Mayo Connect. I'm a lung cancer survivor with COPD and Emphysema. One of my doctors told me about certain doctors and pharmacies playing with trials. It's disheartening at best. And I agree, how does that give hope to anyone?
May I ask what brings you to Connect and how can we help?

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