Clobetasol propionate for lichen sclerosus

I've used Clobetesol for lichens planus and it was effective for decreasing the itch, but the effect is not a lasting one. The rash returns and remaining free is not a cure with Clobetesol.

@bushselbasket Welcome to Mayo Clinic Connect! Glad to have you here.

I thought I had lichen sclerosus, but instead it was diagnosed as some kind of dermatitis with precancerous cells. I was prescribed Clobetesol for the itch. It helped - sort of, but not consistently. My doctor took a biopsy, that mostly removed the tissue in that area - however, it has come back - just not as itchy. I only use the Clobetesol when the itching becomes a problem. I just don't think it's highly effective, just helpful - and it's one of those things they want you to use whether you have symptoms or not.

I have been using clobetasol, but my Dermatologist also just prescribed tacrolimus ointment. Upon application it causes intense burning and itching. This is supposed to be normal for this ointment, but it is lasting longer thatn 20 minutes. Has anyone experienced this?

Yes the itching is awful. Couldn’t the medication at all.

My drs office suggests chilling it before applying. Helps prevent sting/burn

I found that clobetasol cream does indeed burn. I now have mine put into an ointment base at a compounding pharmacy and it is 100% better.

I’ll have no burning before applying, then afterwards I’m stuck on the toilet with the burning peeing feeling, but not peeing. The clobatosol definitely helps tears and inflammation but is painful with every application. Is this normal? Any tips?

@aewelch
This has helped me: In a bowl of lukewarm water (¼ gallon) mixed with one teaspoon of baking soda, soak a large washcloth. Apply it to the affected area for about one minute; it helps soothe the burning. Gently pat the area dry, then apply clobetasol.
Repeat twice a day and keep the area dry.

I have been using clobetasol since 08/2025 with no problem. I use it every other day and Estrogen Cream on the alternative days. About 3 weeks ago a began having all over body itching, especially the day after using the Clobetasol. I started having tingling in my tongue and lips and roof of the mouth. My GYN said impossible that the clobetasol was the culprit. Granddaughters that are both nurses/ and Nurse Practitioner insisted that I cease using the clobetasol. My PC Doc had me take Prednisone 20 mg for 5 days and also Pepcid/Allegra 2xdaily for 2 weeks. No itching whatsoever. Upon completion of the Pepcid/Allegra duo the itching came back with a vengeance all facial related roof of mouth, tongue and lips. PC Doc ordered a Steroid dose pack because sometimes if the steroid is taken long enough the allergic reaction comes back. Has anyone else had a delayed allergic reaction to Clobetasol. Going to see a Dermatologist tomorrow that specializes in autoimmune issues.