C. difficile – Are your guts ever normal again?

At one time is a company open biome used to allow people who had suffered C. difficile infection’s to bank their stool with open biome, so that they could receive their own healthy stool in FMT. The next best thing is to use a close blood relative, preferably one who lives with you, because you know their health habits, their standard of living, and any health problems they may have. You share their genes. The chance of successful FMT is much greater. However, open biome decided that this was no longer a practice that was economically sensible for them. It was far more efficient to use donors, even though that was far more dangerous to the recipient. If I had to have FMT because Zinplava failed, I would use my daughter a healthy 42-year-old whose grandparents on both sides lived into their 90s. She also eats all organic and has made responsible life choices. Interestingly, since open biome discontinued, their practice of stool banking and allowing family members to be their stool donor, FMT is often performed at home as a do it yourself procedure. It’s an enema, which is not as effective as doing it via colonoscopy, but it is reportedly very successful. There are apparently a lot of videos out there that explain how to do FMT at home. I haven’t looked at them yet because I am hoping Zinplava works for me again. It’s been a little over two weeks and so far so good. My recurrence was the result of my dentist, using an antiseptic to fill the canal. After a root canal and to control the swelling, he gave me a steroid. Avoid steroids they suppress your immune system. Between the two of them I was back in the soup of CDI.

Quote: My recurrence was the result of my dentist, using an antiseptic to fill the canal. After a root canal and to control the swelling, he gave me a steroid. Avoid steroids they suppress your immune system. Between the two of them I was back in the soup of CDI.

Oh no! What was wrong with frozen peas on cheek? Was he an Endodontist? I have had several root canals and never given steroids.
I do have a twin brother I could call on. I can't imagine implanting it at home!

Didn't know about steroids. And I just started a 6-week dose of Prednisone for severe lung breathing problem. And I have to take it with Bactrim (which is an antibiotic much less risky for C-diff) to avoid fungal lung infection that could be caused by Prednisone.
I just finished 12 days ago a ten-day course of Doxycycline for potential lung infection. So far so good. It is not one of the top five offenders but still a broad-spectrum antibiotic.
I already have lung cancer requiring ongoing treatments, so can't have more problems in lungs. I have to take medication when needed.

Your situation is a lot more complicated than mine. I got a broad-spectrum anabiotic in 1993 for a sinus infection. I didn’t realize until I was in the emergency room on Thanksgiving night that the diarrhea was an infection. I didn’t lose my colon and I didn’t die. Back then the infection was not as hyper virulent as the current version. It did take seven months to resolve on vancomycin though, and I had to leave law school for a term to lower my stress. In 1994 I didn’t know how vulnerable I was and I was routinely given antibiotics for various infections. I also used ibuprofen as a painkiller, and at one time took an SSRI antidepressant. I didn’t realize until recently that those were damaging. I was also kind of hooked on diet soda. That’s bad for the Microbiome. I contracted a hypervigilant version of CDI when my husband was in the hospital for end-of-life care. They put him in a room where someone had this infection and at that time I didn’t realize that hand sanitizer wouldn’t kill it and that it was some thing you ingested. I brought a sandwich to encourage my husband to eat. And then I had a much more complicated problem. It didn’t resolve for 14 months and I ended up doing a lot of research online for methods for a resolving this. I found a doctor after listening to a panel discussion on this infection on a website called contagion live. They were talking about treatment options, including FMT. A new infusion called bezlotoxumab was getting good results. It is made by Merck pharmaceuticals and it is called Zinplava. It worked for me. It took a long time for the IBS to go away, but it did. I told the endodontist that I could not take antibiotics so he did not prescribe them. He prescribed ibuprofen and a low-dose steroid to reduce swelling. They both worked well, but they suppressed my immune system. So I set up another infusion after recovering on Dificid which resolved my symptoms and gave my microbiome several weeks to recover. I stopped the Dificid after the infusion and except for a little scare, the infusion is holding up. It’s fully active for 19 days and then fades. It does what Dificid does, cripples toxin B. It doesn’t rebuild the immune system. So I’m working on that with probiotics, a vegetable intensive diet, no artificial anything, no pain killers. I just found a doctor in Chicago who is researching microbiome rebuilding. Also a new vaccine is in stage 2 clinical trials for CDI. And rather than FMT, there are trials of propagating, good bacteria outside of the human micro biome. They extract and isolate the good bacteria and then replicate it. So what you get aren’t the bad habits/lifestyle of an impoverished FMT donor, you just get the good bacteria in as diverse a colony as they can provide. I’m interested in that as a treatment option and sign me up for the vaccination. I am a very healthy person except for this infection. I am almost 70. I was overweight, but decided to fix that by starting a walking program. It worked. I joined a nice gym and work out with a personal trainer twice a week. I can do 20 push-ups and dead lift 100 pounds. I cycle, swim, hike and play endless hours of pickleball, usually without injury. After reading your challenges, I know my life is truly blessed, and I will pray for you. Hang in there. The human body is pretty amazing. Do you have 100% got this

It's been almost five months since I got C-Diff from an antibiotic and still having a hard time. I've developed an itchy rash on my scalp that's now spreading to my stomach and lower back. My dermatologist wanted to give me steroids but I can't take them with my Glaucoma. I've tried several drug store products for for the itchiness and rash but nothing seems to help.
I also have waves of just feeling sick and weak during the day. I'm just not myself anymore. Am I not giving it enough time to heal? I'm just looking for some hope!

WHAT ABOUT A STEROID SHAMPOO LIKE CLOBETASOL, NEED A SCRIPT.

ALSO FOR ITCHING GOOD OLD FASHIONED BENADRYL.

JUST A THOUGHT, FEEL BETTER. I ALSO AM GOING ON 3 MONTHS SINCE I GOT CDIFF, HAD A BOUT 20 YEARS AGO. SUPPOSEDLY IF THIS IS YOUR FIRST BOUT, THE ANTIBIOTIC MIGHT TAKE IT AWAY, HOWEVER FOR ME. I CAUGHT A BOUT OF IT 20 YEARS AGO. NOW DOCTORS TELL ME THAT SINCE THIS IS MY SECOND BOUT, THE TOXIN WILL ALWAYS COME BACK IF I NEED AN ANTIBIOTIC LETS SAY FOR PNEUMONIA. THEY TOLD ME SO EACH TIME, I NEED AN ANTIBIOTIC FOR SOMETHING ELSE. I MUST ALSO TAKE VANCOMYCIN BUT IN A LOWER DOSE WITH THE ANTIBIOTIC AND FOR 5 DAYS AFTER YOU FINISH THE OTHER ANTIBIOTIC TO HELP PREVENT THIS FROM ACTING UP.MANY SAY IT TAKES A LONG TIME , MORE SO IF YOU HAVE OTHER HEALTH ISSUES, GOT TO JUST DO ONE THING A DAY, AND THEN REST, FOR ME THE PAINS IN UPPER AND LOWER STOMACH, ARE HORRENDOUS. AND THE NAUSEA, BUT ZOFRAN HELPS THAT. THEY ALSO HAVE BENTYL FOR STOMACH CRAMPS, AND PROBIOTIC FLORASTER THERE ARE MANY MEDICAL REPORTS, THAT SAY IT HELPS TO TAKE EVERY DAY. HOWEVER ITS LIKE $40 A BOTTLE OF 100, AND YOU TAKE 2 A DAY, I JUST STARTED IT A WEEK AGO, BUT IT IS THE ONLY PROBIOTIC THAT HAS MEDICAL DOCUMENTATION ON IT HELPING CDIFF.

IM A RESPIRATORY THERAPIST, BUT THANK GOD I WORK REMOTELY. MY TOILET IS CLOSE. ITS A TERRIBLE BACTERIA TO HAVE. FEEL BETTER, KAREL

Thank you for your response Karel. I got C-Diff from an antibiotic that I didn't think I needed but I trusted my doctor. I never knew you could get it from an antibiotic. I took a course of Vancomycin and then had a recurrence and was put on a taper. It hasn't come back and I pray that it never will! I hope in time I will improve. One day at a time. I pray for healing for you, Karel. Feel Better, Mary

You probably have a fungal infection.
Are you on antibiotics for cdiff such as vancomycin?
I had the same condition but it was sores on my head, face, chest and back. The vancomycin was the cause, I was allergic and I itched like crazy.
I use dial soap, the yellow bar that’s antibacterial.
I was also prescribed metronidazole gel and tacrolimus ointment.
Cdiff makes you tired and nauseous besides, diarrhea and other symptoms.
I’m on a third round of antibiotics called difficid. My infectious disease doctor prescribed ondansetron for nausea.
If you are having these bad side effects please contact your infectious disease doctor or make an appointment with one.
I hope you feel better!

You can also use a nizoral shampoo or CLN shampoo or sulfur 8 shampoo for your scalp.

My apologies! Also, a good probiotic like florastor is imperative for your gut.
All of my good flora is wiped out.
I got an antibiotic resistant infection during one of my spinal surgeries.
I was on IV antibiotics for a year.
I developed Cdiff from the strong IV antibiotics.
I also take oil of oregano gel tablets, manuka honey, zinc and garlic gel tablets.
Good luck!

IHello,
I just had a fecal transplant and it was not successful. They didn't tell me that I had to hold the liquid in for 12 hours, so all the liquid came out when I went to the bathroom and when I got dressed to come home. I am 75 yrs. old and have had this on and off for 7 months. Have tried Vancomycin and Dificid. Didn't work. I would suggest the transplant, but make sure all
info is given to you. Also, my Gastroenterologist nicked his finger while in the process. Yikes!!. I will try again using another Doctor.

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