Brinsupri plus immune modulator / biologic?

Posted by lvnl @lvnl, 4 hours ago

Hello all! After failed NTM treatment and then RSV + Pneumonia + other infections while on Humira for crohns ... The Humira is on pause. Also there's a suggestion that asthma may be more of an issue for me than bronchiectasis and NTM which are mild .... So with all my doctors we are evaluating how to go forward. Bronchiectasis doc would like me on brinsupri but not with Humira, which has systemic immune-suppressing effects. The asthma doctor would like me on one of the new asthma biologics which maybe?? could be taken with brinsupri but not with Humira. My crohns doctor would like me to restart treatment but with one of the newer IL-23 suppressing biologics which target inflammation in the GI & don't have as much of a systemic immune-suppressing effect as Humira does.

So my question is, does anyone have experience being treated with brinsupri plus a biologic? What were the indications and how are you being monitored ... since there's very little experience or data as of yet. But many of us with bronchiectasis also have autoimmune conditions so this must be a question coming up out there!

(An aside: I cannot take arikayce as it seems I had an inflammatory respiratory response to either that or the placebo when in an arikayce study & since then have had bouts of high eosinophils (in blood work) which altogether is suggesting eosinophilic asthma.)

Thanks to everyone here for all the generous sharing of information and experience... this is an invaluable group!

Interested in more discussions like this? Go to the MAC & Bronchiectasis Support Group.

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