Brinsupri experience after 3+ months

@heidi0974 Hearing this is encouraging, as I have just started Brinsupri (25mg). Thank you!

I began 25 mg in March and mucus production and coughing lessened a lot. I amost felt normal About 3 months in, the secretions increased and now at 5 months, I'm back to feeling very congested, especially at night, which really affects my sleep.

Have you had a sputum test to see if there's anything brewing?

@mary22
I have to say that I am prone to coughing at night, which disturbs my sleep. Frustrating. What has helped is moving clearance to earlier than right before bedtime, and also taking an alginate product before sleep. Reflux Raft or Reflux Gourmet. I also take a daily allegra, which seems to lessen the gunk in my chest.

@mary22 I'm in the same boat. I felt much better at 3 months, but now at 5-6 months the coughing is worse with lots of sputum. The dryness side effect seems to make the cough more aggressive. Nasal drainage has increased, but it's difficult to ascertain the source. No infection signs, the last culture was clear. Unfortunately I'm not making forward progress.

I have been on 25 mg Brinsupri for six months and am having the same experience. After three months I was feeling good but now I am experiencing a lot of congestion and coughing again at night. I have Bronchiectasis, MAC and Pseudomonas. The Pseudomonas seems to be under control by nebulizing Colistimethate twice daily after airway clearance and the MAC is stable for now without meds. I am hoping as time goes on that the Brinsupri will bring relief to the coughing and the constant mucus production. I wish you well on your journey with this disease.

@jago Sounds like an exasperation. Have you contacted your pulmonologist? You may need RX. I've had 2 very mild exasperations due to high pollen counts and AQI. I increased my nebulizing to 3 times/day (I used 3.5 % midday) and had to increase my Airsupra inhalant. Both exasperations passed without antibiotics. Knock on wood.

@kathyjjb I have an appt. with my NJH infectious disease doctor in 2.5 weeks, so I hope to get answers then. It could be an exasperation, although sputum color is mostly normal. Upping the clearance is a good idea. Definitely challenging pollen and AQI numbers here.

@jago Sounds like allergies/AQI-unfortunately, it often leads to infection. I get it, it has been so miserable here in Phoenix Valley. Good luck at NJH!

I am from Germany and have been taking Brinsupri since July 8, 2026; I hardly cough anymore. I used to have a severe, irritating cough and a lot of phlegm. Now there is very little, and the phlegm is very light-colored—no longer yellow or green. However, for the past week, I’ve noticed itchy, fluid-filled red pimples on my face. I’ve already made an appointment with a dermatologist. Does anyone have experience with this? Also, how long does one have to—or should one—take Brinsupri?