Brensocatib Aspen Trial Results in NEJM!

Posted by becleartoday @becleartoday, Apr 26 9:10am

This diagram — “Neutrophils: Defender and Offender” — is what Dr. Chalmers often refers to as a “confusagram” (I think that’s the word he uses!).

Does anyone remember Highlights magazine, where you had to find hidden objects — like a hammer tucked inside a tree?
That’s exactly what this feels like!

Can you spot the word brensocatib hidden in the diagram?

Many of us have been following the development of brensocatib for years, from the Phase 2 WILLOW trial to the Phase 3 ASPEN trial.

Although the results were shared publicly last year and discussed extensively at the Bronchiectasis World Conference in Dundee, Scotland, the findings have now been formally published in The New England Journal of Medicine, one of the most prestigious medical journals in the world.

I knew the article was coming, as I’ve heard Dr. Chuck Daley reference it multiple times. How exciting — for him, for the bronchiectasis community, and for all of us living with the heavy burden of this disease and desperately needing relief.

So, as I always say, let’s continue to stay the course: keep our weight in a healthy zone, eat nutrient-dense foods, do our airway clearance, exercise, control GERD, and just as importantly, try to have faith and relax — knowing that help is on the way!

Happy weekend,
Linda Esposito

Interested in more discussions like this? Go to the MAC & Bronchiectasis Support Group.

dpaula | @dpaula | Apr 29 4:57pm

In reply to @beejenigma "I was at the Lung Institute at DMC for years and I had Dr Kissner, who..." + (show)

I have not received care at DMC. I am currently in the Henry Ford Hospital Health System. I have had the same pulmonologist since 2016 when I was diagnosed with BE. I have received very good care with my current pulmonologist but at times I have debated about seeking a BE specialized pulmonologist. My husband and my pulmonologist worked together so I do get extra attention and prompt responses for any problems but sometimes I feel like I might be missing out on some state of the art bronchiectasis care. Thank you @beejenigma for bringing Dr. Kissner to my attention. If Brensocatib becomes available only to certain pulmonologists I will be getting that second opinion. I am very concerned about my volume of sputum per day and random intense coughing jags (about two per week) that are extremely scary. Again thank you.

heathert | @heathert | Apr 30 4:08am

In reply to @becleartoday "Hi everyone, I posted about the NEJM article to my social media and one of our..." + (show)

Hi Linda, thanks for posting, that is fantastic news, I also live in NZ, I hope it will become available here!!!! Heather

minute22 | @minute22 | Apr 30 6:55am

In reply to @spider109 "OMG this sounds sooooo promising! Hopefully it gets approved by the FDA soon!! I believe that..." + (show)

If you're talking about Brensocatib, it has been approved and is set to be rolled out to patients on August 12th, I believe.

dpaula | @dpaula | Apr 30 9:40am

In reply to @minute22 "If you're talking about Brensocatib, it has been approved and is set to be rolled out..." + (show)

According to the latest info: "As of April 24, 2025, Brensocatib has not yet received FDA approval. However, the New Drug Application (NDA) for brensocatib to treat non-cystic fibrosis bronchiectasis is currently under Priority Review by the FDA. The target action date for the FDA's decision is August 12, 2025." So the final decision will be announced on August 12 and then it will be rolled out to patients hopefully soon afterwards.

jill6063 | @jill6063 | Apr 30 9:59am

Hi friends -

I read this message string this morning (while I am at NJH waiting for my appointment with Dr. Charles Daley!), so I asked him the question about approval. He said is it slated for approval in August, and should be available to patients at the end of 2025 or the beginning of 2026. He called the study a "home run," saying that it did everything they wanted it to do - even the secondary hoped-for benefits, something he said rarely happens! So it's great to have something good coming our way!

He also said the 20% decrease in exacerbations is huge, because some are viral and there is nothing we can do about those, AND, this was only at 52 weeks. He said it could continue to get better with more time, we just don't know!

It's nice to have something to be hopeful about!

Kind regards,
Jill

scoop | @scoop | Apr 30 10:53am

In reply to @jill6063 "Hi friends - I read this message string this morning (while I am at NJH waiting..." + (show)

Thanks for the real-time update! I hoped for an early Q3 release, given Insmed has already manufactured the tablets for the trial. Oh well. When the end is near, the intolerable becomes unbearable.