Arikayce & air trapping?

Posted by lvnl @lvnl, 13 hours ago

Hi all, has anyone on (inhaled) Arikayce developed air trapping? I am on month 3 of daily ethambutol, Azithromycin, and inhaled Arikayce or placebo (in a clinical study). After some initial improvement my cough and fatigue worsened substantially & my pulmonologist team suspected air trapping due to inflammation triggered by the Arikayce (or placebo?). This is an asthma-like reaction. I started Albuterol before airway clearance and Arikayce inhalation, which has helped a lot. Pulmonary function test confirms air trapping (even with great improvement). The docs reassure that this is a common side effect that resolves when I go off the med (or placebo although this would seem to indicate I'm getting the med). Has anyone experienced this, and what was the outcome? Many thanks for the wealth of information and shared experience here!

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