Anyone partaking in this clinical trial for low dose Tam?

At my request my onco gave me the CYP2D6 test, which determines how well I would metabolize Tam. Should I need to take it she will dose accordingly. Meanwhile I get a Guardant Reveal test every three months to detect cancer cell presence. So far so good. FWIW: I strongly encourage second opinions + doing your own research. I brought the CYP2D6 test to my onco’s attention, then she researched it. Cancer is a business and medicine in this country is driven by big pharma. I realized that to achieve my desired outcomes I must be my own project manager, researching options, managing risks, and coordinating efforts among siloed medical fields (e.g. GI, onco, nutrition). Blessings and hearty encouragement to you all because YOU are your own best advocate.

Thank you for posting @1ek I know there are others on this dosage, maybe not in a trial. I am really happy that you are tolerating this dosage well.
Are you at a normal menopause age, or is this induced menopause from the endocrine therapy?

I started the discussion because my onco doc suggested that I would be a good candidate for the low Tam trial due to my type of BC cancer and I wanted to know how someone on this drug at the lower dose was tolerating it however, after signing up for the trial, I was not chosen for the group to take 5mg of Tamoxifen but chosen for the other group which is a normal dose of an AI. After reading through a lot of the comments here on this forum, I opted not to participate and dropped out of the trial. I was willing to try the 5mg of Tam but not a higher dose of another drug. I even asked my doc do I have to participate in the clinical trial to get 5mg of Tam and the answer was "YES", which I found concerning. What drove home my decision not to take any drugs at this time were 2 comments the doc said to me and those were "well, you also have to consider your quality of life in making a decision" and "the drugs are to reduce distant recurrence". "Distant" recurrence I wondered? I'm 68 years old. So if taking an AI is only reducing recurrence later in my life and at a very small percentage, I'd rather enjoy the time I have left and not have to constantly battle with side effects of the drug, even if they are mild. What is most frustrating to me about BC treatment is after all these years and tons of money thrown at research, this is the best you got for us??? I am on the prowl now to seek out a 2nd opinion for my treatment, if any, however, I am not holding my breath that much will change. I will continue to maintain a healthy diet, stay active and get plenty of sleep in hopes that my cancer doesn't return. That's the best choice I think I have made for myself right now going forward.

At my request my onco gave me the CYP2D6 test, which determines how well I would metabolize Tam. Should I need to take it she will dose accordingly. Meanwhile I get a Guardant Reveal test every three months to detect cancer cell presence. So far so good. FWIW: I strongly encourage second opinions + doing your own research. I brought the CYP2D6 test to my onco’s attention, then she researched it. Cancer is a business and medicine in this country is driven by big pharma. I realized that to achieve my desired outcomes I must be my own project manager, researching options, managing risks, and coordinating efforts among siloed medical fields (e.g. GI, onco, nutrition). Blessings and hearty encouragement to you all because YOU are your own best advocate.

I started the discussion because my onco doc suggested that I would be a good candidate for the low Tam trial due to my type of BC cancer and I wanted to know how someone on this drug at the lower dose was tolerating it however, after signing up for the trial, I was not chosen for the group to take 5mg of Tamoxifen but chosen for the other group which is a normal dose of an AI. After reading through a lot of the comments here on this forum, I opted not to participate and dropped out of the trial. I was willing to try the 5mg of Tam but not a higher dose of another drug. I even asked my doc do I have to participate in the clinical trial to get 5mg of Tam and the answer was "YES", which I found concerning. What drove home my decision not to take any drugs at this time were 2 comments the doc said to me and those were "well, you also have to consider your quality of life in making a decision" and "the drugs are to reduce distant recurrence". "Distant" recurrence I wondered? I'm 68 years old. So if taking an AI is only reducing recurrence later in my life and at a very small percentage, I'd rather enjoy the time I have left and not have to constantly battle with side effects of the drug, even if they are mild. What is most frustrating to me about BC treatment is after all these years and tons of money thrown at research, this is the best you got for us??? I am on the prowl now to seek out a 2nd opinion for my treatment, if any, however, I am not holding my breath that much will change. I will continue to maintain a healthy diet, stay active and get plenty of sleep in hopes that my cancer doesn't return. That's the best choice I think I have made for myself right now going forward.

At my request my onco gave me the CYP2D6 test, which determines how well I would metabolize Tam. Should I need to take it she will dose accordingly. Meanwhile I get a Guardant Reveal test every three months to detect cancer cell presence. So far so good. FWIW: I strongly encourage second opinions + doing your own research. I brought the CYP2D6 test to my onco’s attention, then she researched it. Cancer is a business and medicine in this country is driven by big pharma. I realized that to achieve my desired outcomes I must be my own project manager, researching options, managing risks, and coordinating efforts among siloed medical fields (e.g. GI, onco, nutrition). Blessings and hearty encouragement to you all because YOU are your own best advocate.