Any experience with Nexletol or Nexlezet?

It took me months to understand what caused what, but finally understood that a mix of causes included Repatha in a major way. Also if you are taking 2 monoclonal antibodies like I was, is there any science that tells us how that works?

Nexletol is working for me! My total cholesterol is barely above 200, HDL and LDL are “pretty good”. I’ve just started started taking pravastatin with Nexletol. Considering how sick from Repatha and from other statins (other than low doses of pravastatin), I’m very happy! Nexletol is expensive, but no more than one ER out of pocket.

Same here. Statins and Praluent are out for me. I am now on Nexletol and Zetia. It is helping. I have LP(a). My Dr wants my LDL to be below 30. It's 55. It was 120. I don't seem to have any side effects. I also take Benacol a stanol supplement in a chocolate chew. Dr Dayspring says to attack the receptors in the liver and intestines. If you do one or the other, the organ that is not medicated, will put out more receptors.

What were your Praluent side effects? My second dose I had tingly lips and tongue, like it was an allergic reaction.

Best wishes.

Thanks for your post. With Praluent I experienced extreme fatigue. I went to urgent care thinking something was seriously wrong. Given the long half life of the medication it took about 8 weeks to recover. I’m going to start Nexletol this week.

I hope it works well for you!

Was placed on nexlizet, developed gout, unable to urinate, cramps in leg , issues resolved after the med stopped. Never had any of these issues before taking this med. Be very careful.

Interesting question, @tatiana987. You may have mentioned the other monoclonal antibody drug you are taking but I am not seeing it.

What else are you taking besides Repatha? Did you start them at the same time?

I have taken Prolia for osteoporosis for nearly 10 years, I had some reactions to the shots in the beginning (injections were every 6 months). For about 3 years, I used Benedryl for that. Then I seemed to adjust and used the Prolia without Benedryl until the present time. For the most recent shot I had about a week of light headedness and minor nausea,

I began Repatha September 29, 2024, took 17 injections on a 2 week schedule. I didn’t make the connection to my problems with light headedness and falling until my neurologist took my drivers license away and I was in a horrible panic and unable to continue my normal, healthy life style. I tried to turn myself into a scientist and reviewed all medical records, as well as my own records. I figured out my problem by talking to Amgen, the manufacturer of both monoclonal antibodies and by using Dr. Google, where I found thus group,

Sad thing is that both Prolia and Repatha did what they were supposed to do. My labs and dexa scans were lots better.