Have others experienced a near complete drug intolerance as a result of taking many RA drugs? After 8 years of dealing with multiple drugs, I can walk very little and now use a wheelchair when I have to go anywhere, which is seldom. Biologics blow up my knees like balloons. They never really made me any better, only worse, and I am pretty much in constant pain. I feel as if my life has been taken away from me. After being treated by the same doctor for 7 years, I finally let him go. It was one of the hardest things I have ever done and even after a year, it is still very painful to me. I finally decided I had to go to Mayo and they are still working on something that can actually help rather than hurt me. I still have other specialists to see. I wrote a story about my experience with Mayo thus far. If you would like to read it, you can send me a message and I will give you a link.