Tapering Off of Effexor

Posted by frances007 @frances007, Nov 26, 2023

I have used the tapering suggestion that was offered by another member, and it has worked well for me. I am currently on 37.5mg, and have been at this dose for quite some time. Over the past few days I tried emptying some of the medication out of the capsule and adding it to my coffee in the morning. I tried this over the course of a few days, and noticed that I was feeling much more tearful than usual. Granted, I have recently undergone a horrible and traumatic experience, and this may be a contributing factor, but the depth of my sorrow was so great that I surprised myself. Is this a common reaction? I will certainly ask my neurologist about this on Wednesday, but wondered if anyone has had a similar response. As a side bar, since tapering off of this drug, I am sleeping better and having less headaches, which is a very good thing. Thank you very much for all of your help.

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All these comments are so helpful. Tapering down from 75 mg Effexor to 37.5 was no big deal. Then the simply dreadful nightmares started, and I couldn't get through my day. I'm not young (76) but I'm determined to get off this poison and have a better life with the years I have left. Thanks for the info on the jeweller's scale, the teaspoon and 10%. Such a help.

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@frances007

in reply to @kelvinthomas Thank you very much. I am working on tapering from 37.5 mg downward. I tried weighing the small "pebbles" inside the capsule on my kitchen scale, but they did not register. My next option will be to add them to a 1/4 teaspoon and try to decrease a little each day. Interestingly enough, I am still having nightmares, even when I went back to the 37.5 mg, ones that I wish I did not remember, as they are so real and relate to the recent horrible experience of a couple of weeks ago. I did discuss all of this with my psychologist who also is a MD, and she cautioned me to go very slowly because this medication is "all time awful." I had no idea that at one time it was pulled from the market, and suppose I should not be surprised that my doctor prescribed it in the first place. I know I no longer have a "chemical imbalance" in terms of my depression, as it is primarily the consequences of living with a chronic, incurable illness, When I tapered from the 150 mg to 112.5 mg I had no serious side effects, just sort of feeling "out of it" for the first week or so. After a few weeks I went down to the 75mg as described on this platform, then finally to the 37.5mg where I am at present. Yes, I am still young, but even still, I feel the relevance of coping with my ever changing physical maladies, if you will. I am still determined to remain strong and active as I possibly can, even if it makes me feel worse on some days. I really wish sometimes I were wired to curl up in a ball and feel what people have called, "immobilized." But I just cannot give in. Doctors understand so little today as it is, and I have found a way to navigate the system to the best of my ability, even if that means going against the advice of my doctor. Thank you for telling me about the nightmares, as I have never experienced such vivid ones in the past that actually wake me up.

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Weighing did not work for me either. I found it worked well to open capsule and remove and throw away 2 white pebbles/spansules out of each capsule for the next month.
After that month take out 4 white pebbles from each capsule for the next 30or 60 days.
Then when you feel level and adjusted. Take out 5 out of each for next month and so on and so on. It takes many months to wean down but it’s better than experiencing the withdrawal symptoms. Have patience.

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@sassysaveur

Weighing did not work for me either. I found it worked well to open capsule and remove and throw away 2 white pebbles/spansules out of each capsule for the next month.
After that month take out 4 white pebbles from each capsule for the next 30or 60 days.
Then when you feel level and adjusted. Take out 5 out of each for next month and so on and so on. It takes many months to wean down but it’s better than experiencing the withdrawal symptoms. Have patience.

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If you look at the research, you are decreasing the dose in the wrong direction. One should start by removing more beads in the beginning (no more than ten percent) and reduce by fewer and fewer beads over time. If you think about it, this makes sense because removing more and more beads would mean you are decreasing the dosage by a larger percentage of the drug, which is not what you want to do. See this link for a better explanation:

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@njoys

If you look at the research, you are decreasing the dose in the wrong direction. One should start by removing more beads in the beginning (no more than ten percent) and reduce by fewer and fewer beads over time. If you think about it, this makes sense because removing more and more beads would mean you are decreasing the dosage by a larger percentage of the drug, which is not what you want to do. See this link for a better explanation:

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in reply to @sassysaveur Thank you! I appreciate this information very much. Those beads are so tiny, that removing them feels like I am back in the chemistry lab in college. I will move ahead as you have suggested, as I really want to get off of this medication. I do not need it and do not want to take it going forward. After the discussion with my psychologist, who is also a MD, I am even more determined to remove this medication from my already spilling over medicine cabinet. This information is so helpful!

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@mgd46

I had very good success tapering by measuring beads. Purchased jewelers scale and capsules. Weighed beads in original capsule. Set up schedule by reducing bead weight by 10% each month based on previous month. Doing the same now with Temazepam (powder in capsules). Good luck on your tapering program. You can do it!

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in reply to @mgd46 Thanks. I am going to talk to my pharmacist, as I am sure she will help me in this regard. I do not want to purchase a jewelers scale for obvious reasons. I have a very close relationship with my pharmacist, and have no doubt that she will be able to prepare the medication as described. This way I know that it is being done correctly and eliminates the hassle for me to have a chemistry lab in my kitchen. Good advice, though and thank you again

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@frances007

in reply to @sassysaveur Thank you! I appreciate this information very much. Those beads are so tiny, that removing them feels like I am back in the chemistry lab in college. I will move ahead as you have suggested, as I really want to get off of this medication. I do not need it and do not want to take it going forward. After the discussion with my psychologist, who is also a MD, I am even more determined to remove this medication from my already spilling over medicine cabinet. This information is so helpful!

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I did this reduction over a period of a year for my adult child. It’s tedious taking out an additional spansule every month or two but it worked. He’s been completely free of Effexor for over 5 years now and it’s a great feeling.
I will say he did get a few zaps here and there but nothing near as bad as it could have been. The reduction of one more spansule each month or two is not a science. You could consider reducing one spansule every other day for a month and then every day for the second month and continue that way. See how you feel as you go. There were some months we stayed at same dose a bit longer so as to acclimate. It’s by no means as controlled as I would have liked it to be.
I actually called the manufacturer and a pharmacist. I learned that the spansules are not equal in size/dosage. But honestly, it was the best I thought I could do.
The best part is taking control and getting off of the drug and moving forward with your life. Cheers to you!

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@sassysaveur

I did this reduction over a period of a year for my adult child. It’s tedious taking out an additional spansule every month or two but it worked. He’s been completely free of Effexor for over 5 years now and it’s a great feeling.
I will say he did get a few zaps here and there but nothing near as bad as it could have been. The reduction of one more spansule each month or two is not a science. You could consider reducing one spansule every other day for a month and then every day for the second month and continue that way. See how you feel as you go. There were some months we stayed at same dose a bit longer so as to acclimate. It’s by no means as controlled as I would have liked it to be.
I actually called the manufacturer and a pharmacist. I learned that the spansules are not equal in size/dosage. But honestly, it was the best I thought I could do.
The best part is taking control and getting off of the drug and moving forward with your life. Cheers to you!

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Can't argue with success! I misunderstood the process as you described it earlier; I apologize for that. This sounds like a very slow lowering of the dose over a long period of time, and I hope to do this myself beginning in January. THANK YOU.

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in reply to @sassysaveur Thank you for the comment. I went to the pharmacy earlier and my pharmacist said again that Effexor is a great drug until you do not need it anymore. Further, he stated that this drug is THE MOST DIFFICULT drug to go off of, and he cautioned me about going "cold turkey" for the last stretch. He said it could take many more months of tapering, cutting down on those beads a little more each week.
Interestingly enough, the other pharmacist, who has become a friend, told me that in her opinion, many doctors do not take enough courses in medical school to study pharmacology, which of course, is very important. My PCP is a perfect example, telling me to go from 150 mg to 75mg, which was disastrous to say the least.
I am so grateful for all of this information, and suspect I am finally headed in the right direction.

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@sassysaveur

I did this reduction over a period of a year for my adult child. It’s tedious taking out an additional spansule every month or two but it worked. He’s been completely free of Effexor for over 5 years now and it’s a great feeling.
I will say he did get a few zaps here and there but nothing near as bad as it could have been. The reduction of one more spansule each month or two is not a science. You could consider reducing one spansule every other day for a month and then every day for the second month and continue that way. See how you feel as you go. There were some months we stayed at same dose a bit longer so as to acclimate. It’s by no means as controlled as I would have liked it to be.
I actually called the manufacturer and a pharmacist. I learned that the spansules are not equal in size/dosage. But honestly, it was the best I thought I could do.
The best part is taking control and getting off of the drug and moving forward with your life. Cheers to you!

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Once you open the capsules to remove beads, do you have to put the beads back in the capsule to swallow the drug?

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@njoys

Once you open the capsules to remove beads, do you have to put the beads back in the capsule to swallow the drug?

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Yes all the beads should be in capsule except for the amount you are reducing by.
I tried not to dump them out. I carefully opened capsule and sprinkled a few out in my palm/hand. Counted and through away the amount I wanted to take out and then put all beads back into capsule, cover and put into my pill counter container or id doing it daily, cover and pop in mouth.
I highly recommend writing down the date and dose of Effexor, and how many spansules you’re taking out. It’s easy to forget. I would stay in same steady amount t for at least a month or more to give body time to adjust.

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